Synthesis and Characterization of Poly N- isopropylacrylamide Thermosensitive Based Cryogel

Year 2013, Volume: 41 Issue: 2, 159 - 166, 01.06.2013

Veyis Karakoç Deniz Türkmen Huma Shaikh Nilay Bereli Cenk A. Andac Adil Denizli

Abstract

The aim of this study was to reveal the changes in the nanostructure of the thermo-sensitive poly N- isopropylacrylamide-N methacryloyl- L -histidine [poly NIPA-MAH ] monolithic cryogel with changing temperature around lower critical solution temperature LCST of NIPA. Poly NIPA-MAH cryogel was prepared by free radical cryopolymerization of NIPA with MAH as a functional comonomer and N,N-methylene- bisacrylamide MBAAm as crosslinker directly in a plastic syringe. Cryo-polymerization was initiated by N,N,N,N-tetramethylene diamine TEMED and ammonium persulfate APS pair at subzero temperature -16ºC in an ice bath. LCST of poly NIPA-MAH cryogel was found to be 34ºC. The surface morphology and bulk structure of poly NIPA-MAH cryogel was revealed with scanning electron microscopy SEM . Poly NIPA- MAH cryogel with 60–100 μm pore diameter has a specific surface area of 42.6 m2/g polymer. Poly NIPA- MAH cryogel was characterized by Fourier transform infrared spectrometer FTIR and swelling test. The equilibrium swelling degree of poly NIPA-MAH cryogel was 22.08 g H2O/g for dry cryogel. The presence of NIPA makes cryogel morpholgy highly porous and differentiates it from conventional gels.

Keywords

N-isopropylacrylamide NIPA, thermosensitive polymers, cryogels, histidine

Poli N-izopropilakrilamid bazlı kriyojelin sentez ve karakterizasyonu

Abstract

B u çalışmanın amacı NIPA’nın düşük kritik çözelti sıcaklığı LCST civarındaki sıcaklık değişimlerine karşı pH’ya ve sıcaklığa duyarlı poli N-izopropilakrilamid-N metakriloil- L -histidin [poli NIPA-MAH ] monolitik kriyojelin nanoyapısındaki değişimleri açıklamaktır. Poli NIPA-MAH kriyojel plastik şırınga içerisinde NIPA’nın fonksiyonel komonomer olarak kullanılan MAH ile serbest radikal kriyokopolimerizasyonu ile hazırlanmış olup N,N-metilen-bisakrilamid MBAAm çapraz bağlayıcı olarak kullanıldı. Kriyopolimerizasyon N,N,N,Ntetrametilen diamin TEMED ve amonyum persülfat APS çifti ile buz banyosunda sıfırın altındaki sıcaklıkta -16ºC başlatıldı. Poli NIPA-MAH kriyojelin LCST değeri 34ºC olarak bulundu. Poli NIPA-MAH kriyojelin yüzey morfolojisi ve yığın yapısı taramalı elektron mikroskobu SEM ile belirlenmiştir. 60–100 µm por çapına sahip poli NIPA-MAH kriyojel 42.6 m2/g polimer değerinde yüzey alanına sahiptir. Poli NIPA-MAH kriyojel Fourier dönüşümlü kızılötesi spektrometre FTIR ve şişme testi ile karakterize edildi. Kuru kriyojelin denge şişme derecesi 22.08 g HO/g olarak bulundu. Geleneksel jellerle karşılaştrıldığında, bu gözenekli kriyojel şekli NIPA’ya hızlı yanıt verme olanağı sağlar

Keywords

N-izopropilakrilamid NIPA, sıcaklığa duyarlı polimerler, kriyojeller, histidin

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