Synthesis and Characterization of CoII, NiII, CuII and ZnII Cation Complexes with Tyrptophan. Investigation of Their Biological Properties ​

Year 2013, Volume: 41 Issue: 2, 167 - 177, 01.06.2013

Aliye Kaşarcı Dursun Ali Kose Gülçin Alp Avcı Emre Avci

Abstract

The complexes of CoII, NiII, CuII and ZnII metal cations with tryptophan amino acid were synthesized and characterized by FT-IR, TG/DrTG-DTA, UV-Vis spectroscopy and elemental analysis methods. The complexes were synthesized with high purity. The results of the elemental analysis indicated that the complexes contain two molecules of tryptophan as monoanionic bis-chelated ligands per mole formula unit that are coordinated acidic oxygen κ-O and amine grops κ-N and two moles coordinated aqua ligands in CoII, NiII and ZnII complexes, the CuII has just one mole aqua ligand so its geometry is square pyramidal. The others have octahedral geometry.

Keywords

Amino acid complexes, Tryptophan-metal complexes, Thermal decomposition, Antimicrobial, Antioxidant

Triptofan-CoII, NiII, CuII ve ZnII Katyon Komplekslerinin Sentezi ve Karakterizasyonu. Bu Komlekslerin Biyolojik Özelliklerinin İncelenmesi

Abstract

T riptofan amino asidi-CoII, NiII, CuII ve ZnII metal katyon kompleksleri sentezlenmiş ve FT-IR, TG / DrTG- DTA, UV-Vis spektroskopisi ve elementel analiz yöntemleriyle karakterize edilmiştir. Kompleksler yüksek saflıkta sentezlendi. Elementel analiz sonuçları, komplekslerin, koordine asidik oksijen k-O ve amin grupları k-N olan bir mol formül birimi için mono anyonik bis-şelatlayıcı ligand olarak 2 triptofan molekülü ve CoII, NiII ve ZnIIkomplekslerinde iki mol koordine su ligandı içerdiğini göstermektedir. CuII bir mol su ligandına sahiptir ve dolayısıyla geometrisi kare piramittir. Diğerleri oktahedral geometriye sahiptir.Son olarak, komplekslerinin biyolojik aktiviteleri, anti-bakteriyel, anti-mikrobiyal ve anti-mantar olarak incelenmiştir. Sentezlenen metal kompleksleri disk difüzyon yöntemi ile anti-mikrobiyal aktivite için test edilmiştir. Bu çalışmaların sonuçları, metal komplekslerinin, bir veya daha fazla türe karşı daha fazla antimikrobiyal olduğunu göstermektedir. Ayrıca, metal komplekslerinin toplam antioksidan kapasitesinin Zn II -trp ve Ni II -trp kompleksleri için diğer komplekslerden daha fazla olduğu belirlenmiştir

Keywords

Amino asit kompleksleri, Triptofan-metal kompleksleri, Termal ayrışma, Antimikrobiyal, Antioksidan

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