Anticancer Properties of Different Species of Salvia

Işıl Yıldırım; Türkan Kutlu

Anticancer Properties of Different Species of Salvia

Year 2015, Volume: 43 Issue: 2, 91 - 97, 01.06.2015

Abstract

Historically, thousands of different species of plant have been reported as being useful for the treatment of cancer. Salvia species think among these plants. Salvia; “sage” are derived from the Latin salvere referring to remedy properties arrogate to the various Salvia species. Salvia is the largest genus of plants in the mint family, Lamiaceae. In this review we performed to report the anticancer features of different species of salvia

Keywords

Salvia, Anticancer activity

References

1. World Health Organization, February 2014. Retrieved 10 June 2014.
2. National Cancer Institute. Retrieved 10 June 2014.
3. S. Yılmaz., Cell proliferation was inhibited 50 % by different IC50 values calculated in different assays and different time intervals, Doctora thesis. 2013.
4. M.R. Loizzo, F. Menichini, R. Tundis, M. Bonesi, F. Nadjafi, A.M. Saab, N.G. Frega, F. Menichini., Comparative Chemical Composition and Antiproliferative Activity of Aerial Parts of Salvia leriifolia Benth. and Salvia acetabulosa L. Essential Oils Against Human Tumor Cell In Vitro Models, J Med Food., 13 (2010) 62-9.
5. M. Shoemaker, B. Hamilton, S.H. Dairkee, I. Cohen M.J. Campbel., In vitro anticancer activity of twelve Chinese medicinal herbs, Phytotherapy Research. 19 (2005) 649–651.
6. H. Özer, A. Altun, S. Unver-Saraydın, S. Soylu, S. Göktaş, E. tuncer, D.S. İnan, B. Köksal, T. Kaya Temiz, B. Tepe, M. Şen, K. Karadayı, M. Turan., antitumor effects of salvia abscondifflora Greuter&Burdet Syn.Salvia Crytantha Montbret&aucher ex Benth. on breast cancer, Indian journal of traditional knowledge. 12 (2013) 390-397.
7. R. Abu-Dahab, F. Afifi., Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7), Scientia Pharmaceutica. 75 (2007) 121-136 .
8. M.I. Choudheary, A. Hussain, A. Adhikari, B.P. Marasini, S. Sattar, A. Wahab., Anticancer and α-chymotrypsin inhibiting diterpenes and triterpenes from Salvia leriifolia, Phytochemistry Letters. 6 (2013) 139–143.
9. W.S. Itani, S.H. El-Banna, S.B. Hassan, R.L. Larsson, A. Bazarbachi, H.U. Gali-Muhtasib., Anti-colon cancer components from Lebanese sage (Salvia libanotica) essential oil, Cancer Biol Ther., 7 (2008) 1765-73.
10. Z. Amirghofran, F. Zand, K. Javidnia, R. Miri., The Cytotoxic Activity of Various Herbals against Different Tumor Cells: An in vitro Study, Iranian Red Crescent Medical Journal., 12 (2010) 260-265.
11. G. Fiore, P. Massereli, M. Sajeva, F.G. Franchi., Anti-tumor activity of the methanolic extracts of Salvia menthifolia, Rev. Bras. Farmacogn. Braz. J. Pharmacogn., 22 (2012) 381-388.
12. S. Sertel, T. Eichhorn, P.K. Plinkert, T. Efferth., Anticancer activity of Salvia officinalis essential oil against HNSCC cell line. (UMSCC1). HNO. 59 (2011) 1203- 8.
13. F.Z. Shahneh, S. Valiyari, B. Baradan, J. Abdolalizadeh, A. Bandehagh, A. Azadmehr, R. Hajiaghee., Inhibitory and Cytotoxic Activities of Salvia Officinalis L. Extract on Human Lymphoma and Leukemia Cells by Induction of apoptosis, Advanced Pharmaceutical Bulletin. 3 (2013) 51-55.
14. G.P.P. Kamatou, R.L. Van-Zyl, , H. Davids, F.R. Van Heerden, A.C.U. Lourens, A.M. Viljoen., Antimalarial and anticancer activities of selected South African Salvia species and isolated compounds from S. radula, South African Journal of Botany. 74 (2008) 238-243.
15. M.R. Loizzo, M. Abouali, P. Salehi, A. Sonboli, M. Kanani, F. Menichini, R. Tundis., In vitro antioxidant and antiproliferative activities of nine Salvia species, Natural Product Research: Formerly Natural Product Letters. 28 (2014) 2278-2285.
16. G. Fiore, C. Nencini, F. Cavallo, A. Capasso, A. Bader, G. Giorgi, L. Micheli, In vitro Antiproliferative Effect of Six Salvia species on human tumor cell lines, Phytotherapy Research. 28 (2006) 701-703.
17. A. Gali-Muhtasif., Anticancer and medicinal properties of essential oil and extracts of East Mediterranean sage (Salvia triloba), Lead Molecules from Natural Products: Discovery and New Trends. 171-183.
18. O. Firuzi, R. Miri, M. Asolalahi, S. Eslami, A.R. Jassibi., Cytotoxic, Antioxidant and Antimicrobial Activities and Phenolic Contents of Eleven Salvia Species from Iran, Iranian Journal of Pharmaceutical Research. 12 (2013) 801-810.
19. M. Akaberi, S. Mehri, M. İranshahi., Multiple proapoptotic targets of abietane diterpenoids from Salvia species, Fitoterapia. 100 (2015) 118–132
20. X. Chen, J. Guo, J. Bao, J. Lu, Y. Wang., The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review, Med Res Rev., 34(4) (2014) 768-94.
21. S. Hu, S.M. Che, X.K. Li, R. Qın, Z.N. Mei., Antitumor effects of Chi-Shen extract from Salvia miltiorrhiza and Paeoniae radix on human hepatocellular carcinoma cells, Acta Pharmacology. 28 (2007) 1215–1223.
22. G. Fiore, P. Maseralli, M. Sajeva, G.G. Franchi., Anti-tumor activity of the methanolic extracts of Salvia menthifolia, Brazilian Journal of Pharmacognosy. 22 (2012)381-388.
23. J. Bauer, S. Kuehenl, J.M. Rollinger, O. Secherer, H. Northoff, H. Stupner, O. Werz, A. Koebarle., Carnosol and Carnosic Acids from Salvia officinalis Inhibit Microsomal Prostaglandin E2 Synthase-1, The Journal of Pharmacology and Experimental Therapeutics 342 (2012) 169–176.
24. R. Tundis, M.R. Loizzo, F. Menichini, M. Bonesi, C. Colica, F. Menichini., In vitro cytotoxic activity of extracts and isolated constituents of Salvia leriifolia Benth. against a panel of human cancer cell lines, Chemistry Biodiversty. 8 (2011) 1152–1162.
25. R. Abu-Dahap, F. Affif, V. Kasabri, L. Majdalavi, R. Naffa., Comparison of the antiproliferative activity of crude ethanol extracts of nine salvia species grown in Jordan against breast cancer cell line models, Pharmagonosy magazine. 8 (2012) 319-324.
26. M.R. Loizzo, M. Abuali, P. Salehi, A. Sonboli, M. Kanani, F. Menichini, R. Tundis., In vitro antioxidant and antiproliferative activities of nine Salvia species, Natural Product Research: Formerly Natural Product Letters. 24 (2014) 2278-2285.
27. J. Alzeer, B.R. Vumiddi, R. Arefeh, W. Rimawi, H. Saleem, N.W. Luedtke., The influence of extraction solvents on the anticancer activities of Palestinian medicinal plants Journal of Medicinal Plant Research. 8 (2014) 408-415.
28. H. Gali-Muhtasif., Anticancer and medicinal property of essential oil and extract of east Mediterranean sage (Salvia triloba), Leads molecule from Natural Product. (2006) 169-180.
29. J.Z. Al-Kalaldeh, R. Abu-Dahab, F.U. Afifi.,“Volatile oil composition and antiproliferative activity of Laurus nobilis, Origanum syriacum, Origanum vulgare, and Salvia triloba against human breast adenocarcinoma cells,” Nutrition Research. 30 (2010) 271–278.
30. W.S. Itani, S.H. El-Banna, S.B. Hassan, L.R. Larson, A. Bazarbach, H.U. Gali-Muhtsip., Anti colon cancer components from Lebanese sage (Salvia libanotica) essential oil, Cancer Biology & Therapy. 7 (2008) 1765- 1773.
31. H.U. Gali-Muhtasib, N.I. Affara., Chemopreventive effects of sage oil on skin papillomas inmice, Phytomedicine. 7 (2000) 129–136.
32. A. Russo, C. Formisano, D. Rigano, F. Senatore, S. Delfine, V. Cardile, S. Roselli, M. Bruno., Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions, Food and Chemical Toxicology. 55 (2013) 42–47.
33. M.R. Loizzo, F. Menichini, R. Tundis, M. Bonesi, F. Nadjafi, A.M. Saab, N.G. Frega, F. Menichini., Comparative Chemical Composition andAntiproliferative Activity of Aerial Parts of Salvia leriifolia Benth. and Salvia acetabulosa L. Essential Oils Against Human Tumor Cell in vitro Models. J Med Food., 13 (2010) 62-9.
34. M.R. Loizzo, R. Tundis, F. Menichini, A.M. Saab, G.A. Statti, F. Menichini., Cytotoxic Activity of Essential Oils from Labiatae and Lauraceae Families Against in vitro Human Tumor Models. Anticancer Res. 27 (2007) 3293- 3299.
35. Z. Amirghofran, F. Zand, K. Javidnia, R. Mirri., The Cytotoxic Activity of Various Herbals against Different Tumor Cells: An in vitro Study, Iranian Red Crescent Medical Journal. 12 (2010) 260-265.
36. Z. Tayarani-Najaran, J. Asili, A. Aiobi, S.A. Emami., Growth Inhibition and Apoptosis Induction of Salvia chloroleuca on MCF-7 Breast Cancer Cell Line, Iranian Journal of Pharmaceutical Research. 12 (2013) 789-799.
37. A. Russo, V. Cardile, A.C.E. Graziano, C. Formisano, D. Rigano, M. Canzoneri, M. Bruno, F. Senatore, Comparison of essential oil components and in vitro anticancer activity in wild and cultivated Salvia verbenaca. Natural Product Research., (2014) 1-11.
38. X. Chen, J. Guo, J. Bao, J. Lu, Y. Wang., The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): A systematic review, Med Res Rev., 34 (2014) 768-94.
39. R. Abu-Dahab, F. Afifi., Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7), Scientia Pharmaceutica. 75 (2007) 121-136.
40. G. Sridharan, P. Brindha, R. Raja, R. Amutha-Priya. Invitro and in-vivo cytotoxic effect of salvia leucantha cav. against each cell lines, International Journal of Pharmacy and Pharmaceutical Sciences. 4 (2012) 143- 146.
41. G. Shu, W. Zhao, L. Yue, H. Su, M. Xiang. Antitumor immunostimulatory activity of polysaccharides from Salvia chinensis Benth, Journal of Etnopharmacology. 20 (2015) 237-47
42. L. Zhou, Z. Zuo, M.S.S. Chow. Danshen an overview of its chemistry Pharmacology pharmacokinetics and clinical use, J. Clin. Pharmacol., 45 (2005) 1345–1359.
43. X.H. Wang, K.F. Bastow, C.M. Sun, Y.L. Lin, H.J. Yu, M.J. Don, T.S. Wu, S. Nakamura, K.H. Lee. Antitumor Agents 239 Isolation structure elucidation total synthesis and anti–breast cancer activity of neotanshinlactone from Salvia miltiorrhiza, J. Med. Chem., 47 (2004) 5816–5819.
44. S. Hu, S.M. Chen, X.K. Li, R. Qin, Z.N. Mei., Antitumor effects of Chi-Shen extract from Salvia miltiorrhiza and Paeoniae radix on human hepatocellular carcinoma cells, Acta Pharmacology Sin., 28 (2007) 1215–1223.
45. C.P.R.F. Xavier, C. Lima, M. Fernandes-Ferreira, C. Pereira-Wilson. Salvia Fruticosa, Salvia Officinalis, and Rosmarinic Acid Induce Apoptosis and Inhibit Proliferation of Human Colorectal Cell Lines: The Role in MAPK/ERK Pathway, Nutrition and Cancer. 61 (2009) 564–571.
46. C.P.R.F. Xavier, C. Lima, M. Fernandes-Ferreira, C. Pereira-Wilson., Induction of apoptosis and inhibition of proliferation in colon cancer cells by Salvia fruticosa, Salvia officinalis and rosmarinic acid, Planta Med., (2008) 74 - PA19.
47. S.K. Azar, R.E. Mooen, H. Niknahad., Cytotoxicity of Juniperus excels and Salvia mirzayanii Extracts against HepG2 Cells, Iranian Journal of Pharmaceutical Sciences. 8 (2012) 241-247.
48. N.K. Dehaghi, S.N. Ostad, N. Maafi, S. Pedram, Y. Ajani, A. Hadjiakhoondi, M. Khanavi., Cytotoxic activity of the essential oil of Salvia verticillata L, Research Journal of Pharmacognosy (RJP). 1 (2014) 27-33.
49. C.Y. Lee, H.F. Sher, H.W. Chen, C.C. Liu, C.H. Chen, C.S. Lin, P.C. Yang, H.S. Tsay, J.J.W. Chen., Anticancer effects of tanshinone I in human non-small cell lung cancer, Molecular cancer therapeutics. 7 (2008) 3527- 3538.
50. V. Kafil, M. Eskandandi, Y. Omidi, H. Nazemiyeh, J. Barar. Abietane diterpenoid of Salvia sahendica Boiss and Buhse potently inhibits MCF-7 breast carcinoma cells by suppression of the PI3K/AKT pathway, RSC Adv., 5 (2015) 18041-18050.

Farklı Salvia Türlerinin Antikanser Özellikleri

Year 2015, Volume: 43 Issue: 2, 91 - 97, 01.06.2015

Işıl Yıldırım Türkan Kutlu

Abstract

T arih boyunca binlerce farklı bitki türünün kanser tedavisinde kullanımı rapor edilmiştir. Salvia türleri de bu bitkiler arasındadır. Adaçayı, çeşitli salvia türlerine atıfta bulunmak için latincede salvare kelimesinden türemiştir. Salvia Lamiaceae ailesinin en geniş bitki türüdür. Bu derlemede farklı salvia türlerinin anti kanser özelliği hakkında bilgi verme amaçlanmıştır

Keywords

Salvia, Anti kanser aktivite

References

1. World Health Organization, February 2014. Retrieved 10 June 2014.
2. National Cancer Institute. Retrieved 10 June 2014.
3. S. Yılmaz., Cell proliferation was inhibited 50 % by different IC50 values calculated in different assays and different time intervals, Doctora thesis. 2013.
4. M.R. Loizzo, F. Menichini, R. Tundis, M. Bonesi, F. Nadjafi, A.M. Saab, N.G. Frega, F. Menichini., Comparative Chemical Composition and Antiproliferative Activity of Aerial Parts of Salvia leriifolia Benth. and Salvia acetabulosa L. Essential Oils Against Human Tumor Cell In Vitro Models, J Med Food., 13 (2010) 62-9.
5. M. Shoemaker, B. Hamilton, S.H. Dairkee, I. Cohen M.J. Campbel., In vitro anticancer activity of twelve Chinese medicinal herbs, Phytotherapy Research. 19 (2005) 649–651.
6. H. Özer, A. Altun, S. Unver-Saraydın, S. Soylu, S. Göktaş, E. tuncer, D.S. İnan, B. Köksal, T. Kaya Temiz, B. Tepe, M. Şen, K. Karadayı, M. Turan., antitumor effects of salvia abscondifflora Greuter&Burdet Syn.Salvia Crytantha Montbret&aucher ex Benth. on breast cancer, Indian journal of traditional knowledge. 12 (2013) 390-397.
7. R. Abu-Dahab, F. Afifi., Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7), Scientia Pharmaceutica. 75 (2007) 121-136 .
8. M.I. Choudheary, A. Hussain, A. Adhikari, B.P. Marasini, S. Sattar, A. Wahab., Anticancer and α-chymotrypsin inhibiting diterpenes and triterpenes from Salvia leriifolia, Phytochemistry Letters. 6 (2013) 139–143.
9. W.S. Itani, S.H. El-Banna, S.B. Hassan, R.L. Larsson, A. Bazarbachi, H.U. Gali-Muhtasib., Anti-colon cancer components from Lebanese sage (Salvia libanotica) essential oil, Cancer Biol Ther., 7 (2008) 1765-73.
10. Z. Amirghofran, F. Zand, K. Javidnia, R. Miri., The Cytotoxic Activity of Various Herbals against Different Tumor Cells: An in vitro Study, Iranian Red Crescent Medical Journal., 12 (2010) 260-265.
11. G. Fiore, P. Massereli, M. Sajeva, F.G. Franchi., Anti-tumor activity of the methanolic extracts of Salvia menthifolia, Rev. Bras. Farmacogn. Braz. J. Pharmacogn., 22 (2012) 381-388.
12. S. Sertel, T. Eichhorn, P.K. Plinkert, T. Efferth., Anticancer activity of Salvia officinalis essential oil against HNSCC cell line. (UMSCC1). HNO. 59 (2011) 1203- 8.
13. F.Z. Shahneh, S. Valiyari, B. Baradan, J. Abdolalizadeh, A. Bandehagh, A. Azadmehr, R. Hajiaghee., Inhibitory and Cytotoxic Activities of Salvia Officinalis L. Extract on Human Lymphoma and Leukemia Cells by Induction of apoptosis, Advanced Pharmaceutical Bulletin. 3 (2013) 51-55.
14. G.P.P. Kamatou, R.L. Van-Zyl, , H. Davids, F.R. Van Heerden, A.C.U. Lourens, A.M. Viljoen., Antimalarial and anticancer activities of selected South African Salvia species and isolated compounds from S. radula, South African Journal of Botany. 74 (2008) 238-243.
15. M.R. Loizzo, M. Abouali, P. Salehi, A. Sonboli, M. Kanani, F. Menichini, R. Tundis., In vitro antioxidant and antiproliferative activities of nine Salvia species, Natural Product Research: Formerly Natural Product Letters. 28 (2014) 2278-2285.
16. G. Fiore, C. Nencini, F. Cavallo, A. Capasso, A. Bader, G. Giorgi, L. Micheli, In vitro Antiproliferative Effect of Six Salvia species on human tumor cell lines, Phytotherapy Research. 28 (2006) 701-703.
17. A. Gali-Muhtasif., Anticancer and medicinal properties of essential oil and extracts of East Mediterranean sage (Salvia triloba), Lead Molecules from Natural Products: Discovery and New Trends. 171-183.
18. O. Firuzi, R. Miri, M. Asolalahi, S. Eslami, A.R. Jassibi., Cytotoxic, Antioxidant and Antimicrobial Activities and Phenolic Contents of Eleven Salvia Species from Iran, Iranian Journal of Pharmaceutical Research. 12 (2013) 801-810.
19. M. Akaberi, S. Mehri, M. İranshahi., Multiple proapoptotic targets of abietane diterpenoids from Salvia species, Fitoterapia. 100 (2015) 118–132
20. X. Chen, J. Guo, J. Bao, J. Lu, Y. Wang., The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review, Med Res Rev., 34(4) (2014) 768-94.
21. S. Hu, S.M. Che, X.K. Li, R. Qın, Z.N. Mei., Antitumor effects of Chi-Shen extract from Salvia miltiorrhiza and Paeoniae radix on human hepatocellular carcinoma cells, Acta Pharmacology. 28 (2007) 1215–1223.
22. G. Fiore, P. Maseralli, M. Sajeva, G.G. Franchi., Anti-tumor activity of the methanolic extracts of Salvia menthifolia, Brazilian Journal of Pharmacognosy. 22 (2012)381-388.
23. J. Bauer, S. Kuehenl, J.M. Rollinger, O. Secherer, H. Northoff, H. Stupner, O. Werz, A. Koebarle., Carnosol and Carnosic Acids from Salvia officinalis Inhibit Microsomal Prostaglandin E2 Synthase-1, The Journal of Pharmacology and Experimental Therapeutics 342 (2012) 169–176.
24. R. Tundis, M.R. Loizzo, F. Menichini, M. Bonesi, C. Colica, F. Menichini., In vitro cytotoxic activity of extracts and isolated constituents of Salvia leriifolia Benth. against a panel of human cancer cell lines, Chemistry Biodiversty. 8 (2011) 1152–1162.
25. R. Abu-Dahap, F. Affif, V. Kasabri, L. Majdalavi, R. Naffa., Comparison of the antiproliferative activity of crude ethanol extracts of nine salvia species grown in Jordan against breast cancer cell line models, Pharmagonosy magazine. 8 (2012) 319-324.
26. M.R. Loizzo, M. Abuali, P. Salehi, A. Sonboli, M. Kanani, F. Menichini, R. Tundis., In vitro antioxidant and antiproliferative activities of nine Salvia species, Natural Product Research: Formerly Natural Product Letters. 24 (2014) 2278-2285.
27. J. Alzeer, B.R. Vumiddi, R. Arefeh, W. Rimawi, H. Saleem, N.W. Luedtke., The influence of extraction solvents on the anticancer activities of Palestinian medicinal plants Journal of Medicinal Plant Research. 8 (2014) 408-415.
28. H. Gali-Muhtasif., Anticancer and medicinal property of essential oil and extract of east Mediterranean sage (Salvia triloba), Leads molecule from Natural Product. (2006) 169-180.
29. J.Z. Al-Kalaldeh, R. Abu-Dahab, F.U. Afifi.,“Volatile oil composition and antiproliferative activity of Laurus nobilis, Origanum syriacum, Origanum vulgare, and Salvia triloba against human breast adenocarcinoma cells,” Nutrition Research. 30 (2010) 271–278.
30. W.S. Itani, S.H. El-Banna, S.B. Hassan, L.R. Larson, A. Bazarbach, H.U. Gali-Muhtsip., Anti colon cancer components from Lebanese sage (Salvia libanotica) essential oil, Cancer Biology & Therapy. 7 (2008) 1765- 1773.
31. H.U. Gali-Muhtasib, N.I. Affara., Chemopreventive effects of sage oil on skin papillomas inmice, Phytomedicine. 7 (2000) 129–136.
32. A. Russo, C. Formisano, D. Rigano, F. Senatore, S. Delfine, V. Cardile, S. Roselli, M. Bruno., Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions, Food and Chemical Toxicology. 55 (2013) 42–47.
33. M.R. Loizzo, F. Menichini, R. Tundis, M. Bonesi, F. Nadjafi, A.M. Saab, N.G. Frega, F. Menichini., Comparative Chemical Composition andAntiproliferative Activity of Aerial Parts of Salvia leriifolia Benth. and Salvia acetabulosa L. Essential Oils Against Human Tumor Cell in vitro Models. J Med Food., 13 (2010) 62-9.
34. M.R. Loizzo, R. Tundis, F. Menichini, A.M. Saab, G.A. Statti, F. Menichini., Cytotoxic Activity of Essential Oils from Labiatae and Lauraceae Families Against in vitro Human Tumor Models. Anticancer Res. 27 (2007) 3293- 3299.
35. Z. Amirghofran, F. Zand, K. Javidnia, R. Mirri., The Cytotoxic Activity of Various Herbals against Different Tumor Cells: An in vitro Study, Iranian Red Crescent Medical Journal. 12 (2010) 260-265.
36. Z. Tayarani-Najaran, J. Asili, A. Aiobi, S.A. Emami., Growth Inhibition and Apoptosis Induction of Salvia chloroleuca on MCF-7 Breast Cancer Cell Line, Iranian Journal of Pharmaceutical Research. 12 (2013) 789-799.
37. A. Russo, V. Cardile, A.C.E. Graziano, C. Formisano, D. Rigano, M. Canzoneri, M. Bruno, F. Senatore, Comparison of essential oil components and in vitro anticancer activity in wild and cultivated Salvia verbenaca. Natural Product Research., (2014) 1-11.
38. X. Chen, J. Guo, J. Bao, J. Lu, Y. Wang., The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): A systematic review, Med Res Rev., 34 (2014) 768-94.
39. R. Abu-Dahab, F. Afifi., Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7), Scientia Pharmaceutica. 75 (2007) 121-136.
40. G. Sridharan, P. Brindha, R. Raja, R. Amutha-Priya. Invitro and in-vivo cytotoxic effect of salvia leucantha cav. against each cell lines, International Journal of Pharmacy and Pharmaceutical Sciences. 4 (2012) 143- 146.
41. G. Shu, W. Zhao, L. Yue, H. Su, M. Xiang. Antitumor immunostimulatory activity of polysaccharides from Salvia chinensis Benth, Journal of Etnopharmacology. 20 (2015) 237-47
42. L. Zhou, Z. Zuo, M.S.S. Chow. Danshen an overview of its chemistry Pharmacology pharmacokinetics and clinical use, J. Clin. Pharmacol., 45 (2005) 1345–1359.
43. X.H. Wang, K.F. Bastow, C.M. Sun, Y.L. Lin, H.J. Yu, M.J. Don, T.S. Wu, S. Nakamura, K.H. Lee. Antitumor Agents 239 Isolation structure elucidation total synthesis and anti–breast cancer activity of neotanshinlactone from Salvia miltiorrhiza, J. Med. Chem., 47 (2004) 5816–5819.
44. S. Hu, S.M. Chen, X.K. Li, R. Qin, Z.N. Mei., Antitumor effects of Chi-Shen extract from Salvia miltiorrhiza and Paeoniae radix on human hepatocellular carcinoma cells, Acta Pharmacology Sin., 28 (2007) 1215–1223.
45. C.P.R.F. Xavier, C. Lima, M. Fernandes-Ferreira, C. Pereira-Wilson. Salvia Fruticosa, Salvia Officinalis, and Rosmarinic Acid Induce Apoptosis and Inhibit Proliferation of Human Colorectal Cell Lines: The Role in MAPK/ERK Pathway, Nutrition and Cancer. 61 (2009) 564–571.
46. C.P.R.F. Xavier, C. Lima, M. Fernandes-Ferreira, C. Pereira-Wilson., Induction of apoptosis and inhibition of proliferation in colon cancer cells by Salvia fruticosa, Salvia officinalis and rosmarinic acid, Planta Med., (2008) 74 - PA19.
47. S.K. Azar, R.E. Mooen, H. Niknahad., Cytotoxicity of Juniperus excels and Salvia mirzayanii Extracts against HepG2 Cells, Iranian Journal of Pharmaceutical Sciences. 8 (2012) 241-247.
48. N.K. Dehaghi, S.N. Ostad, N. Maafi, S. Pedram, Y. Ajani, A. Hadjiakhoondi, M. Khanavi., Cytotoxic activity of the essential oil of Salvia verticillata L, Research Journal of Pharmacognosy (RJP). 1 (2014) 27-33.
49. C.Y. Lee, H.F. Sher, H.W. Chen, C.C. Liu, C.H. Chen, C.S. Lin, P.C. Yang, H.S. Tsay, J.J.W. Chen., Anticancer effects of tanshinone I in human non-small cell lung cancer, Molecular cancer therapeutics. 7 (2008) 3527- 3538.
50. V. Kafil, M. Eskandandi, Y. Omidi, H. Nazemiyeh, J. Barar. Abietane diterpenoid of Salvia sahendica Boiss and Buhse potently inhibits MCF-7 breast carcinoma cells by suppression of the PI3K/AKT pathway, RSC Adv., 5 (2015) 18041-18050.

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Details

Primary Language	English
Journal Section	Research Article
Authors	Işıl Yıldırım This is me Türkan Kutlu This is me
Publication Date	June 1, 2015
Published in Issue	Year 2015 Volume: 43 Issue: 2

Cite

APA	Yıldırım, I., & Kutlu, T. (2015). Anticancer Properties of Different Species of Salvia. Hacettepe Journal of Biology and Chemistry, 43(2), 91-97.
AMA	Yıldırım I, Kutlu T. Anticancer Properties of Different Species of Salvia. HJBC. June 2015;43(2):91-97.
Chicago	Yıldırım, Işıl, and Türkan Kutlu. “Anticancer Properties of Different Species of Salvia”. Hacettepe Journal of Biology and Chemistry 43, no. 2 (June 2015): 91-97.
EndNote	Yıldırım I, Kutlu T (June 1, 2015) Anticancer Properties of Different Species of Salvia. Hacettepe Journal of Biology and Chemistry 43 2 91–97.
IEEE	I. Yıldırım and T. Kutlu, “Anticancer Properties of Different Species of Salvia”, HJBC, vol. 43, no. 2, pp. 91–97, 2015.
ISNAD	Yıldırım, Işıl - Kutlu, Türkan. “Anticancer Properties of Different Species of Salvia”. Hacettepe Journal of Biology and Chemistry 43/2 (June 2015), 91-97.
JAMA	Yıldırım I, Kutlu T. Anticancer Properties of Different Species of Salvia. HJBC. 2015;43:91–97.
MLA	Yıldırım, Işıl and Türkan Kutlu. “Anticancer Properties of Different Species of Salvia”. Hacettepe Journal of Biology and Chemistry, vol. 43, no. 2, 2015, pp. 91-97.
Vancouver	Yıldırım I, Kutlu T. Anticancer Properties of Different Species of Salvia. HJBC. 2015;43(2):91-7.

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