hittite j sci eng

Hittite Journal of Science and Engineering

2148-4171

Hitit University

10.17350/HJSE19030000172

Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC

Akmese

Bediha

Hitit University, Department of Chemistry, Corum, Turkey

03 26 2020

7 1 51 54

2014

Hittite Journal of Science and Engineering

Stress degradation studies control the behavior and impurities of drugs under various stress conditions. The present research is related to all degradation studies including acidic, alkaline, thermal and photo stability on the drug substance according to International Conference on Harmonization ICH guidelines. In this study, the degradation profiles of macrolide antibiotics “roxithromycin ROX , tilmicosin TIL and tylosin TYL ” under varied stress conditions were investigated. The behavior of these drugs under hydrolytic, oxidative, thermal and photolytic conditions were determined by high performance liquid chromatography HPLC .

Degradation Macrolide Roxithromycin Tilmicosin Tylosin.

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