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Year 2021, Volume 8 , Issue 1, Pages 71 - 77 2021-03-31

Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode

Ebru GÖKMEŞE [1] , Özlem KURTOĞLU [2] , Faruk GOKMEŞE [3]

Abstract

A new differential pulse voltammetric method for the determination of clozapine in drug dosage forms has been described. In this study, the amount of clozapine in commercial forms has been determined at bismuth modified glassy carbon electrode by taking advantage of the electrochemical oxidation of it. The glassy carbon electrode was modified with BiCl3 to prepare the bismuth film electrode. The acetate buffer solution at pH = 5.00 was selected as the supporting electrolyte in where the maximum current was observed for clozapine at the bismuth film electrode. The effect of pH on peak current and peak potential of clozapine was investigated by differential pulse voltammetry (DPV), and the effect of scan rate on the peak current was examined by cyclic voltammetry (CV). With this developed voltammetric method, the detection limit for clozapine in the working range of 1×10-6 M and 10×10-6 M was found to be 6.112×10-9. The amount of clozapine in the drug tablets was stated after the determination of analytical parameters. The recovery study was executed to check the accuracy and precision of the applied method.

Keywords

Clozapine, bismuth film, drug analysis, modified electrode, differential pulse voltammetry

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Details

Primary Language en
Subjects Basic Sciences
Journal Section Research Article
Authors

Orcid: 0000-0002-5807-3494
Author: Ebru GÖKMEŞE (Primary Author)
Institution: HITIT UNIVERSITY
Country: Turkey

Orcid: 0000-0003-4647-3172
Author: Özlem KURTOĞLU
Institution: HİTİT ÜNİVERSİTESİ
Country: Turkey

Orcid: 0000-0002-0275-3941
Author: Faruk GOKMEŞE
Institution: HITIT UNIVERSITY
Country: Turkey
Dates

Application Date : January 20, 2021
Acceptance Date : March 6, 2021
Publication Date : March 31, 2021

Cite

Bibtex @research article { hjse865685, journal = {Hittite Journal of Science and Engineering}, issn = {}, eissn = {2148-4171}, address = {Hitit Üniversitesi Mühendislik Fakültesi Kuzey Kampüsü Çevre Yolu Bulvarı 19030 Çorum / TÜRKİYE}, publisher = {Hitit University}, year = {2021}, volume = {8}, pages = {71 - 77}, doi = {10.17350/HJSE19030000215}, title = {Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode}, key = {cite}, author = {Gökmeşe, Ebru and Kurtoğlu, Özlem and Gokmeşe, Faruk} }
APA Gökmeşe, E , Kurtoğlu, Ö , Gokmeşe, F . (2021). Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode . Hittite Journal of Science and Engineering , 8 (1) , 71-77 . DOI: 10.17350/HJSE19030000215
MLA Gökmeşe, E , Kurtoğlu, Ö , Gokmeşe, F . "Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode" . Hittite Journal of Science and Engineering 8 (2021 ): 71-77 <https://dergipark.org.tr/en/pub/hjse/issue/61101/865685>
Chicago Gökmeşe, E , Kurtoğlu, Ö , Gokmeşe, F . "Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode". Hittite Journal of Science and Engineering 8 (2021 ): 71-77
RIS TY - JOUR T1 - Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode AU - Ebru Gökmeşe , Özlem Kurtoğlu , Faruk Gokmeşe Y1 - 2021 PY - 2021 N1 - doi: 10.17350/HJSE19030000215 DO - 10.17350/HJSE19030000215 T2 - Hittite Journal of Science and Engineering JF - Journal JO - JOR SP - 71 EP - 77 VL - 8 IS - 1 SN - -2148-4171 M3 - doi: 10.17350/HJSE19030000215 UR - https://doi.org/10.17350/HJSE19030000215 Y2 - 2021 ER -
EndNote %0 Hittite Journal of Science and Engineering Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode %A Ebru Gökmeşe , Özlem Kurtoğlu , Faruk Gokmeşe %T Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode %D 2021 %J Hittite Journal of Science and Engineering %P -2148-4171 %V 8 %N 1 %R doi: 10.17350/HJSE19030000215 %U 10.17350/HJSE19030000215
ISNAD Gökmeşe, Ebru , Kurtoğlu, Özlem , Gokmeşe, Faruk . "Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode". Hittite Journal of Science and Engineering 8 / 1 (March 2021): 71-77 . https://doi.org/10.17350/HJSE19030000215
AMA Gökmeşe E , Kurtoğlu Ö , Gokmeşe F . Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode. Hittite J Sci Eng. 2021; 8(1): 71-77.
Vancouver Gökmeşe E , Kurtoğlu Ö , Gokmeşe F . Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode. Hittite Journal of Science and Engineering. 2021; 8(1): 71-77.
IEEE E. Gökmeşe , Ö. Kurtoğlu and F. Gokmeşe , "Differential Pulse Voltammetric Determination of Clozapine in Drug Dosage Forms at Bismuth Film Electrode", Hittite Journal of Science and Engineering, vol. 8, no. 1, pp. 71-77, Mar. 2021, doi:10.17350/HJSE19030000215
Authors of the Article
Ebru GÖKMEŞE [1]
Özlem KURTOĞLU [2]
Faruk GOKMEŞE [3]
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