Case Report
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Serous multicystic papillary adenoma of the ovaries and glandular cystic hyperplasia of uterus in a Guinea Pig (Cavia porcellus)

Year 2021, Volume 5, Issue 3, 144 - 148, 30.12.2021
https://doi.org/10.30704/http-www-jivs-net.999648

Abstract

Cystic changes of ovarian tissue are crucial as they cause infertility in laboratory animals. A 4 years old, weighing approximately 500 g adult, intact guinea pig had pruritic progressive alopecia over the flanks at the dorsal area and abdomen symmetrically, bilaterally for a month. Beside, an abdominal enlargement was observed outside on the guinea pig. Large polycystic ovaries were detected behind the kidneys during ultrasonography. Also abdominal radiography revealed the cystic structures at the same region. Ovariohysterectomy was performed on the animal, multiple thin walled, fluctuant fluid-filled, large cysts measured as 3.9x2.5 and 4.5x2.8 cm diameter were detected at the left and right ovary, respectively. The uterine body was observed normal macroscopically. The guinea pig was died after the operation during reanimation because of the hypothermia. The organ pieces were submitted to pathology for histopathological examination after the operation. Histologic examination demonstrated a diagnosis of serous multicystic papillary adenoma of the ovaries and glandular cystic hyperplasia of uterus. In conclusion, this case report describes the necessity of not to ignore the ovarian pathologies with guinea pigs demonstrate symmetric, bilateral alopecia on the skin and indicates the importance of postoperative care in laboratory animals despite a successful anesthethic choice and operation. 

References

  • Barnes, R., & Rosenfield, R. L. (1989). The polycystic ovary syndrome: pathogenesis and treatment. Annals of Internal Medicine, 110, 386-399.
  • Branson, K. R. (2001). Injectable anesthesics. In H. R. Adams (Ed). Veterinary Pharmacology and Therapeutics. 8th ed. (pp. 213-268). USA: Iowa State University Press.
  • Brodbelt, D. C., Blissitt, K. J., Hammond, R. A., Neath, P. J., Young, L. E., Pfeiffer, D. U., & Wood, J. L. N. (2008). The risk of death: the confidental enquiry into perioperative small animal fatalities. Veterinary Anaesthesia and Analgesia, 35 (5), 365-373.
  • Capello, V. (2006). Clinical approach to the anorectic guinea pig, Proceedings of the North American Veterinary Conference, Orlando, Florida, USA.
  • Dang, V., Bao, S., Ault, A., Murray, C., McFarlane-Mills, J., Chiedi, C., Dillon, M., Todd, J-P., DeTolla, L., & Rao, S. (2008). Efficacy and safety of five injectable anesthetic regimens for chronic blood collection from the anterior vena cava of guinea pig. Journal of the American Associaton Labratory Animal Science, 47 (6), 56-60.
  • Dierschke, D. J., Hutz, R. J., & Wolf, R. C. (1985). Induced follicular atresia in rhesus monkeys: strength-duration relationships of the estrogen stimulus. Endocrinology, 117, 1397-1403.
  • Eden, J. A., & Warren, P. (1999). A review of 1019 consecutive cases of polycystic ovary syndrome demonstrated by utrasound. Australasian Radiology, 43, 41-46.
  • Gaertner, D. J., Hallman, T. M., Hankerson, F. C., & Batchelder, M. A. (1997). Anesthesia and analgesia for laboratory rodents. In, R. E. Fish, M. J. Brown, P. J. Danneman, A. Z. Karas (Eds). Anesthesia and analgesia in laboratory animals. 2nd ed. (pp. 239-282). London: Elsevier.
  • Green, C. J., Knight, J., Precious, S., & Simpkin, S. (1981). Ketamine alone and combined with diazepam or xylazine in laboratory animals: a 10 year experience. Laboratory Animals, 15, 163-170.
  • Keller, L. S. F., Griffith, J. W., & Lang, C. M. (1987). Reproductive failure associated with cystic rete ovarii in guinea pigs. Veterinary Pathology, 24, 335-339.
  • Nalbandov, A.V. (1952). Anatomic and endocrine causes of sterility in female swine. Fertility and Sterility, 3, 100-119.
  • Olson, M. E., & Bruce, J. (1986). Ovarioectomy, ovariohysterectomy and orchidectomy in rodents and rabbits. Canadian Veterinary Journal, 27 (12), 523-527.
  • Paterson, S. (2006). Skin diseases of exotic pets, (pp. 242-244). UK: Blackwell Science Ltd,.
  • Pilny, A. (2014). Ovarian cystic disease in guinea pig. Veterinary Clinics: Exotic Animal Practice, 17, 69-75.
  • Quandt, L. M., & Hutz, R. J. (1993). Induction by estradiol- 17β of polycystic ovaries inthe guinea pig. Biology of Reproduction, 48, 1088-1094.
  • Sauramo, H. (1954). Development, occurrence, function and pathology of the rete ovarii. Acta Obstetricia Gynecologica Scandinavica, 33, 29-46.
  • Van Pelt, L. F. (1977). Ketamine and xylazine for surgical anesthesia in rats. Journal of the American Veterinary Medical Association, 171 (9), 842-844.
  • Young, W. C., Dempsey, E. W., Myers, H. I., Hagquist, C. W. (1938). The ovarian condition and sexual behavior in the female guinea pig. American Journal of Anatomy, 63 (3): 457-487.

Year 2021, Volume 5, Issue 3, 144 - 148, 30.12.2021
https://doi.org/10.30704/http-www-jivs-net.999648

Abstract

References

  • Barnes, R., & Rosenfield, R. L. (1989). The polycystic ovary syndrome: pathogenesis and treatment. Annals of Internal Medicine, 110, 386-399.
  • Branson, K. R. (2001). Injectable anesthesics. In H. R. Adams (Ed). Veterinary Pharmacology and Therapeutics. 8th ed. (pp. 213-268). USA: Iowa State University Press.
  • Brodbelt, D. C., Blissitt, K. J., Hammond, R. A., Neath, P. J., Young, L. E., Pfeiffer, D. U., & Wood, J. L. N. (2008). The risk of death: the confidental enquiry into perioperative small animal fatalities. Veterinary Anaesthesia and Analgesia, 35 (5), 365-373.
  • Capello, V. (2006). Clinical approach to the anorectic guinea pig, Proceedings of the North American Veterinary Conference, Orlando, Florida, USA.
  • Dang, V., Bao, S., Ault, A., Murray, C., McFarlane-Mills, J., Chiedi, C., Dillon, M., Todd, J-P., DeTolla, L., & Rao, S. (2008). Efficacy and safety of five injectable anesthetic regimens for chronic blood collection from the anterior vena cava of guinea pig. Journal of the American Associaton Labratory Animal Science, 47 (6), 56-60.
  • Dierschke, D. J., Hutz, R. J., & Wolf, R. C. (1985). Induced follicular atresia in rhesus monkeys: strength-duration relationships of the estrogen stimulus. Endocrinology, 117, 1397-1403.
  • Eden, J. A., & Warren, P. (1999). A review of 1019 consecutive cases of polycystic ovary syndrome demonstrated by utrasound. Australasian Radiology, 43, 41-46.
  • Gaertner, D. J., Hallman, T. M., Hankerson, F. C., & Batchelder, M. A. (1997). Anesthesia and analgesia for laboratory rodents. In, R. E. Fish, M. J. Brown, P. J. Danneman, A. Z. Karas (Eds). Anesthesia and analgesia in laboratory animals. 2nd ed. (pp. 239-282). London: Elsevier.
  • Green, C. J., Knight, J., Precious, S., & Simpkin, S. (1981). Ketamine alone and combined with diazepam or xylazine in laboratory animals: a 10 year experience. Laboratory Animals, 15, 163-170.
  • Keller, L. S. F., Griffith, J. W., & Lang, C. M. (1987). Reproductive failure associated with cystic rete ovarii in guinea pigs. Veterinary Pathology, 24, 335-339.
  • Nalbandov, A.V. (1952). Anatomic and endocrine causes of sterility in female swine. Fertility and Sterility, 3, 100-119.
  • Olson, M. E., & Bruce, J. (1986). Ovarioectomy, ovariohysterectomy and orchidectomy in rodents and rabbits. Canadian Veterinary Journal, 27 (12), 523-527.
  • Paterson, S. (2006). Skin diseases of exotic pets, (pp. 242-244). UK: Blackwell Science Ltd,.
  • Pilny, A. (2014). Ovarian cystic disease in guinea pig. Veterinary Clinics: Exotic Animal Practice, 17, 69-75.
  • Quandt, L. M., & Hutz, R. J. (1993). Induction by estradiol- 17β of polycystic ovaries inthe guinea pig. Biology of Reproduction, 48, 1088-1094.
  • Sauramo, H. (1954). Development, occurrence, function and pathology of the rete ovarii. Acta Obstetricia Gynecologica Scandinavica, 33, 29-46.
  • Van Pelt, L. F. (1977). Ketamine and xylazine for surgical anesthesia in rats. Journal of the American Veterinary Medical Association, 171 (9), 842-844.
  • Young, W. C., Dempsey, E. W., Myers, H. I., Hagquist, C. W. (1938). The ovarian condition and sexual behavior in the female guinea pig. American Journal of Anatomy, 63 (3): 457-487.

Details

Primary Language English
Subjects Veterinary
Journal Section Case reports
Authors

Kenan UYGUNER This is me
İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, LİSANSÜSTÜ EĞİTİM ENSTİTÜSÜ
0000-0002-8223-7452
Türkiye


Sinem Özlem ENGİNLER (Primary Author)
İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA
0000-0001-6522-285X
Türkiye


Esma YILDAR This is me
İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, LİSANSÜSTÜ EĞİTİM ENSTİTÜSÜ
0000-0002-7856-2367
Türkiye


Gülay YÜZBAŞIOĞLU ÖZTÜRK This is me
İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA
0000-0002-1761-0409
Türkiye


Ahmet GÜLÇUBUK This is me
İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA
0000-0002-9722-8831
Türkiye

Publication Date December 30, 2021
Published in Issue Year 2021, Volume 5, Issue 3

Cite

APA Uyguner, K. , Enginler, S. Ö. , Yıldar, E. , Yüzbaşıoğlu Öztürk, G. & Gülçubuk, A. (2021). Serous multicystic papillary adenoma of the ovaries and glandular cystic hyperplasia of uterus in a Guinea Pig (Cavia porcellus) . Journal of Istanbul Veterinary Sciences , 5 (3) , 144-148 . DOI: 10.30704/http-www-jivs-net.999648

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