hujpharm Hacettepe University Journal of the Faculty of Pharmacy 2458-8806 Hacettepe University 10.52794/hujpharm.1064820 Pharmacology and Pharmaceutical Sciences Eczacılık ve İlaç Bilimleri Galaxaura rugosa (J. Ellis & Solander) J.V. Lamouroux for Cosmeceutical Application: Antioxidant, Antibacterial, Tyrosinase and Elastase Inhibition Properties Galaxaura rugosa (J. Ellis & Solander) J.V. Lamouroux for Cosmeceutical Application: Antioxidant, Antibacterial, Tyrosinase and Elastase Inhibition Properties https://orcid.org/0000-0003-1856-670X Arguelles Eldrin University of the Philippines Los Banos 12 01 2022 42 4 218 227 01 29 2022 09 22 2022 Copyright © 1981, Hacettepe University Journal of the Faculty of Pharmacy 1981 Hacettepe University Journal of the Faculty of Pharmacy

Red seaweeds are considered novel sources of natural products with diverse biological activities that can be harness for drug synthesis. The bioactive properties of red macroalga, Galaxaura rugosa were studied. Results showed that the macroalga contain a total phenolic content (TPC) of 12.11 ± 0.22 mg GAE/g. The antioxidant activity of G. rugosa exhibited potent ABTS+ radical scavenging activity (IC50 = 81.00 μg GAE/ml) and high copper reduction capacity (IC50 = 19.26 μg GAE/ml). Assessment of tyrosinase and elastase inhibition properties of G. rugosa extract showed that the alga has effective inhibitory activity with IC50 of 88.00 μg GAE/ml and IC50 of 243.00 μg GAE/ml, respectively which are more efficient than kojic acid and tocopherol. The seaweed extract exhibited potent antibacterial activities against common bacterial skin pathogens like Staphylococcus aureus (Minimum Inhibitory Concentration (MIC) = 125 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC = 125 μg/ml), and Staphylo- coccus epidermidis (MIC = 250 μg/ml). This study is considered a pioneering investigation that shows the potential of G. rugosa for cosmeceutical application.

Red seaweeds are considered novel sources of natural products with diverse biological activities that can be harness for drug synthesis. The bioactive properties of red macroalga, Galaxaura rugosa were studied. Results showed that the macroalga contain a total phenolic content (TPC) of 12.11 ± 0.22 mg GAE/g. The antioxidant activity of G. rugosa exhibited potent ABTS+ radical scavenging activity (IC50 = 81.00 μg GAE/ml) and high copper reduction capacity (IC50= 19.26 μg GAE/ml). Assessment of tyrosinase and elastase inhibition properties of G. rugosa extract showed that the alga has effective inhibitory activity with IC50 of 88.00 μg GAE/ml and IC50 of 243.00 μg GAE/ml, respectively which are more efficient than kojic acid and tocopherol. The seaweed extract exhibited potent antibacterial activities against common bacterial skin pathogens like Staphylococcus aureus (Minimum Inhibitory Concentration (MIC) = 125 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC = 125 μg/ml), and Staphylo- coccus epidermidis (MIC = 250 μg/ml). This study is considered a pioneering investigation that shows the potential of G. rugosa for cosmeceutical application.

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