hujpharm Hacettepe University Journal of the Faculty of Pharmacy 2458-8806 Hacettepe University 10.52794/hujpharm.1472081 Pharmaceutical Delivery Technologies İlaç Dağıtım Teknolojileri Plant-Mediated Green Synthesis of Silver Nanoparticles and Evaluation of Their Biological Activities Plant-Mediated Green Synthesis of Silver Nanoparticles and Evaluation of Their Biological Activities https://orcid.org/0009-0008-1280-4985 Düzgün Merve HİTİT ÜNİVERSİTESİ https://orcid.org/0000-0002-0347-0222 Kara Aslı Hitit Üniversitesi 12 01 2024 44 4 351 372 04 22 2024 05 27 2024 Copyright © 1981, Hacettepe University Journal of the Faculty of Pharmacy 1981 Hacettepe University Journal of the Faculty of Pharmacy

Compared to other metallic nanoparticles, silver nanoparticles (AgNP) have unique features such as their suitable structural properties, very low bacterial resistance, non-toxicity at low concentrations, high antimicrobial functionality for bacteria, viruses and other eukaryotic microorganisms, as well as the ability to reduce the amount of toxicity in the cell. The fact that the synthesis of AgNPs is easy to process, measurable and has economically attainable benefits provides the opportunity for these particles to be used in different ways in electronics, food packaging, cosmetics industry, medical and medical studies. Synthesis of AgNPs using physical and chemical methods involves the use of toxic chemicals. In recent years, some current methods have been developed to prevent the use of these chemicals, and green synthesis appears to be a highly preferable method as it is obtained from economical, easily processable and accessible materials. The aim of this article is to examine the green synthesis, characterization and biological activities of AgNPs through plants, supported by current literature data. It is thought that the biological activity determinations of biosynthesized AgNPs and their use in different fields will have the potential to be the focus of attention of researchers for prospective studies.

Gümüş nanopartiküller (AgNP), diğer metalik nanopartiküller ile kıyaslandığında yapısal özelliklerinin uygun olması, bakteri direncinin çok düşük olması, düşük konsantrasyonlarda toksik olmaması, bakteri, virüs ve diğer ökaryotik mikroorganizmalar için yüksek antimikrobiyal işlevselliği dışında, hücredeki toksisite miktarını düşürebilmesi ile kendine özgü özelliklere sahiptir. AgNP’lerin sentezinin kolay işlenebilir, ölçülebilir ve ekonomik açıdan ulaşılabilir faydalara sahip olmaları bu partiküllere elektronik, gıda paketleme, kozmetik endüstrisi, tıbbi ve medikal çalışmalarda farklı şekillerde kullanılabilme imkânı sağlar. AgNP’lerin fiziksel ve kimyasal yöntemler kullanılarak sentezi toksik kimyasalların kullanımını içermektedir. Son yıllarda bu kimyasalların kullanımını engellemek için güncel bazı yöntemler geliştirilmiş olup, yeşil sentez bu yöntemlerden ekonomik, kolay işlenebilir, ulaşılabilir materyallerden elde edilmesi ile tercih edilebilirliği yüksek bir yöntem olarak karşımıza çıkmaktadır. Bu makalenin amacı, bitkiler aracılığıyla AgNP’lerin yeşil sentezi, karakterizasyonu ve biyolojik aktivitelerinin güncel literatür verileri ile desteklenerek incelenmesidir. Biyosentezlenmiş AgNP’lerin biyolojik aktivite tayinleri ve buna bağlı olarak farklı alanlarda kullanımları ileriye dönük çalışmalar için araştırmacıların ilgi odağı olma potansiyeline sahip olacağı düşünülmektedir.

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