hujpharm

Hacettepe University Journal of the Faculty of Pharmacy

2458-8806

Hacettepe University

10.52794/hujpharm.1790368

Pharmacognosy

Farmakognozi

Terpenes in Mushrooms: Natural Products with Diverse Therapeutic Activities

https://orcid.org/0009-0009-4807-810X

Avcı

Eda

ANKARA MEDİPOL ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ

https://orcid.org/0000-0003-3373-4759

Kuruüzüm-uz

Ayşe

HACETTEPE UNIVERSITY, FACULTY OF PHARMACY

https://orcid.org/0000-0002-8264-5544

Şöhretoğlu

Didem

HACETTEPE ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK PR.

03 01 2026

46 1 61 71 09 24 2025 11 10 2025

1981

Hacettepe University Journal of the Faculty of Pharmacy

This study provides a comprehensive review of the terpenes found in mushrooms and their potential therapeutic applications. Mushrooms are rich sources of various terpenes, including monoterpenes, sesquiterpenes, diterpenes, and triterpenes, which possess antibacterial, antiviral, antifungal, antiparasitic, antioxidant, anti-inflammatory, antidiabetic, and cytotoxic activities. Notable examples include pleuromutilin, a precursor of the antibiotic retapamulin; ganoderic acids from Ganoderma lucidum with anti-HIV effects; sesquiterpenes from Albatrellus dispansus that are effective against phytopathogenic fungi; and lanostane triterpenes from G. lucidum and G. leucocontextum with neuroprotective effects. The present findings highlight the therapeutic potential of mushroom terpenes. However, the authors underscore the necessity for further in vitro studies to elucidate the mechanisms of action, along with in vivo studies, toxicity investigations, and clinical trials.

Bioactive compounds Mushrooms Natural products Terpenes Therapeutic applications

not applicable

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