B12 Vitamini Desteği Otizimli Çocukların Tedavisinde Etkili midir?

Year 2017, Volume 4, Issue 1, 15 - 27, 02.07.2017

Sümeyra Sevim Aylin AYAZ

Abstract

Otizm, tekrarlayan ve kısıtlı davranışlarla birlikte sosyal iletişim kabiliyetinde bozukluklar ile karakterize kompleks nörogelişimsel bir hastalıktır. Otizmin patojenik mekanizması henüz net olarak açıklanamamaktadır. Ancak hücresel metilasyon kapasitesi ve antioksidan kapasitesindeki değişiklikler metabolik bir bozukluk olduğunu göstermektedir. Bununla birlikte yapılan çeşitli çalışmalarda özellikle bilişsel fonksiyonlar üzerinde hayati rol oynayan folat ve B₁₂ vitaminin diyetle alımında ve plazma seviyelerinde normal çocuklara göre değişiklik olduğuna dair kanıtlar bulunmaktadır. Vitamin B₁₂, antioksidan sisteminde ve hücresel metilasyonda rol alan önemli bir kofaktörtür. Bu nedenle otizmli çocukların tedavisinde ve/veya çeşitli semptomların iyileştirilmesinde B₁₂ tedavisinin etkin olabileceği düşünülmektedir. 

Keywords

otizm, B12 vitamini, homosistein, metilasyon

Are B12 Vitamins Effective İn The Treatment Of Autistic Children?

Abstract

Autism is a complex neurodevelopmental disorder characterised by repetitive and restricted behaviors as well as social communication behaviors. The pathogenetic mechanism of autism has not yet been clarified. However, changes in cellular methylation capacity and antioxidant capacity indicate a metabolic disorder. After all there is evidence that diverse studies have shown that folate and vitamin B₁₂, which play a crucial role in cognitive functions, are in dietary intake and that plasma levels vary with normal children. Vitamin B₁₂ is an important cofactor involved in antioxidant system and cellular methylation. herefore, it is thought that B₁₂ therapy may be effective in the treatment of autistic children and / or in the treatment of various symptoms.

Keywords

autism, vitamin B12, homocysteine, methylation

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