B12 Vitamini Desteği Otizimli Çocukların Tedavisinde Etkili midir?

Year 2017, Volume: 4 Issue: 1, 15 - 27, 02.07.2017

Sümeyra Sevim , Aylin Ayaz

Abstract

Otizm, tekrarlayan ve kısıtlı davranışlarla birlikte
sosyal iletişim kabiliyetinde bozukluklar ile karakterize kompleks
nörogelişimsel bir hastalıktır. Otizmin patojenik mekanizması henüz net olarak
açıklanamamaktadır. Ancak hücresel metilasyon kapasitesi ve antioksidan
kapasitesindeki değişiklikler metabolik bir bozukluk olduğunu göstermektedir. Bununla
birlikte yapılan çeşitli çalışmalarda özellikle bilişsel fonksiyonlar üzerinde
hayati rol oynayan folat ve B₁₂ vitaminin diyetle alımında ve plazma
seviyelerinde normal çocuklara göre değişiklik olduğuna dair kanıtlar
bulunmaktadır. Vitamin B₁₂, antioksidan sisteminde ve hücresel
metilasyonda rol alan önemli bir kofaktörtür. Bu nedenle otizmli çocukların
tedavisinde ve/veya çeşitli semptomların iyileştirilmesinde B₁₂ tedavisinin
etkin olabileceği düşünülmektedir. 

Keywords

otizm, B12 vitamini, homosistein, metilasyon

Are B12 Vitamins Effective İn The Treatment Of Autistic Children?

Abstract

Autism is a complex neurodevelopmental disorder
characterised by repetitive and restricted behaviors as well as social
communication behaviors. The pathogenetic
mechanism of autism has not yet been clarified. However, changes in cellular
methylation capacity and antioxidant capacity indicate a metabolic disorder.
After all there is evidence that diverse studies have shown that folate and vitamin B₁₂,
which play a crucial role in cognitive functions, are in dietary intake and
that plasma levels vary with normal children. Vitamin B₁₂ is an
important cofactor involved in antioxidant system and cellular methylation.
herefore, it is thought that B₁₂ therapy may be effective in the
treatment of autistic children and / or in the treatment of various symptoms.

Keywords

autism, vitamin B12, homocysteine, methylation

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