Nutritional Relationship with Acne Vulgaris

Year 2018, Volume 5, Issue 1, 46 - 59, 27.04.2018

Begümhan ÖMEROĞLU YEL Fatma Esra GÜNEŞ

https://doi.org/10.21020/husbfd.337532

Abstract

Abstract

 

Acne is a long-standing inflammation of the hair-oil gland structure. Although the causes of acne are not fully known, there is a relationship between acne and nutrition. Because the diet can change the amount and content of sebum secretion in the skin.

Objective: The aim of this review is to discuss the effects of dietary factors such as dairy products, green tea, glycemic index-glycemic load, fatty acids, antioxidants, vitamin A and zinc in the diet on the course of acne vulgaris.

Consumption of milk, especially skim milk consumption, contributes to the formation of acne. The use of polyphenol extracts obtained from green tea in the treatment of acne reduced the number of blackheads and caused a decrease in the number of acne. A diet with low glycemic index-glycemic load has been found to cause a significant reduction in acne severity. Inadequate consumption of essential fatty acids leads to inadequate sebum production in the skin. Serum malondialdehyde and serum glutathione peroxidase levels were reported to be lower in individuals with acne complaints. Low A vitamin levels may be a risk factor for acne and acne lesions. Zinc levels in individuals with acne complaints were significantly lower.

Conclusion:Milk restriction, green tea consumption, low glycemic index-glycemic load diet may be recommended for individuals with acne complaints. It may also be advisable that the nutrients be considered to the fat content, the rate of consumption of essential fatty acids. In severe acne, the use of vitamin E and zinc can lead to supportive outcomes.

Keywords

acne, nutrition, milk, zinc, plyphenol

Akne Vulgaris ile Beslenme İlişkisi

Abstract

Özet

 

Akne, kıl-yağ bezi yapısındaki uzun süreli iltihaplanmalardır. Akne nedenleri günümüzde tam olarak bilinmemekle birlikte akne ile beslenme arasında bir ilişki olduğu düşünülmektedir. Çünkü beslenme deri sebum salgı miktarını ve içeriğini değiştirebilmektedir.

Amaç: Bu derlemenin amacı süt ve süt ürünleri, yeşil çay, diyetteki glisemik indeks- glisemik yük, yağ asitleri, antioksidanlar, A vitamini ve çinko gibi diyet faktörlerinin akne vulgarisin seyri üzerindeki etkilerini tartışmaktır.

Süt tüketiminin, özellikle de yağsız süt tüketiminin akne oluşumuna katkı sağladığı bildirilmektedir. Yeşil çaydan elde edilen polifenol ekstratlarının da aknenin tedavisinde kullanımının komedonlari azalttığı, akne sayısında düşüşe neden olduğu bulunmuştur. Düşük glisemik indeks-glisemik yük içeren bir diyetin akne şiddetinde, akne sayısında, serbest androjen indeksinde önemli bir düşüş meydana getirdiği bulunmuştur. Elzem yağ asitlerinin yetersiz tüketiminin ciltte yetersiz sebum üretimine yol açtığı bilinmektedir. Serum malondialdehit ve serum glutatyon peroksidaz seviyelerinin akne şikayeti olan bireylerde daha düşük olduğu ve oksidatif stres düzeylerinin ise belirgin olarak daha yüksek seviyelerde olduğu bildirilmiştir. Çalışmalar düşük A vitamini seviyelerinin akne için bir risk faktörü olabileceğini göstermektedir. Ayrıca akne şikayeti olan bireylerde çinko seviyeleri anlamlı olarak düşük bulunmuştur.

Sonuç:Akne şikayeti olan bireylere süt kısıtlamasının, yeşil çay tüketiminin, düşük glisemik indeks-glisemik yüklü diyetin tavsiye edilebileceği düşünülmektedir. Ayrıca besinlerin yağ içeriğine, elzem yağ asitleri tüketim oranına dikkat etmeleri tavsiye edilebilir. Şiddetli aknede A, E vitamini ve çinko kullanımı tedaviyi destekleyici sonuçlara sebep olabilmektedir.

Keywords

akne, beslenme, süt, çinko, polifenol

References

• Adebamowo, C.A., Spiegelman, D., Berkey, C.S., Danby, F.W., Rockett, H.H., Colditz, G.A. ve diğerleri. (2006). Milk consumption and acne in adolescent girls. Dermatol Online J, 12(4): 1.
• Adebamowo, C.A., Spiegelman, D., Berkey, C.S., Danby, F.W., Rockett, H.H., Colditz, G.A. ve diğerleri (2008). Milk consumption and acne in teenaged boys. J Am Acad Dermatol, 58(5): 787-793.
• Adebamowo C.A., Spiegelman D, Danby, F.W., Frazier, A.L., Willett W.C. & Holmes M.D. (2005). High school dietary dairy intake and teenage acne. J Am Acad Dermatol, 52(2): 207-214.
• Aksoy, M. (2008). Diyet El Kitabı (5.baskı). içinde Baysal, A.(Eds), Cilt Sağlığı ve Hastalıklarında Beslenme. (sf 417-433). Ankara: Hatiboğlu yayınları
• Aksoy, M. (2011). Beslenme Biyokimyası (5.baskı). Ankara: Hatiboğlu yayınları.
• Batya, B., Davidovici, R. & Wolf, M.D. (2010). The role of diet in acne: facts and controversies. Clinics in Dermatology, 28:12-16.
• Book, C.B. & Duraif, A.(1996). Polycystic ovary syndrome. İçinde Chang, J (Eds). İnsulin Resistance in the Polycystic Ovary Syndrome (pp.117-126). Massahusetts: Springer
• Bowe, W.P., Joshi, S.S. & Shalita, A.R. (2010). Diet and Acne. Journal Academic Dermotology, 63(1):124-41.
• Bowe, W.P. & Logan, A.C. (2010). Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles. Lipid Health Dis ,9: 141.
• Bowe, W.P. & Shalita, A.R. (2008). Effective over-the-counter acne treatments. Semin Cutan Med Surg; 27(3), 170-6. doi:10.1016/j.sder.2008.07.004
• Bransnick, J., Murcku, E. & Rao, B. (2014). Diet in dermatology:Part I. Atopic dermatitis, acne, and nonmelanoma skin cancer. Journal American Academic Dermatology, 71(6): 1039e1-12.
• Çerman, A., Aktaş, E., Altunay, İ.K., Arıcı, J.E., Tulunay, A. & Ozturk, F.Y. (2016).Dietary glycemic factors, insülin resistance, and adinopectin levels in acne vulgaris.Journal Academic Dermotology, 75(1): 155-162.
• Chapman, M.S. (2012). Vitamin A: history, current uses, and controversies. Semin Cutan Med Surg, 31: 11–16.
• Cordain, L., Lindeberg, S., Hurtado, M., Hill, K., Eaton, S.B. & Brand-Miller, J.(2002). Acne vulgaris: a disease of western civilization.Arch Dermatol.138; 1584-1590.doi:10.1001/archderm.138.12.1584
• Danby, F.W. (2010). Nutrıtıon and acne. Clinic Dermatology, 28: 598-604.
• Danby, W. (2013). Turning acne on/off via mTORC1. Exp Dermatol, 22: 505-506.
• Di Landro, A., Cazzaniga, S., Parazzini, F., Ingordo, V., Cusano, F., Atzori, L. ve diğerleri (2012).Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults. J Am Acad Dermatol, 67(6): 1129-1135.
• Dreno, B. (2004). Acne: physical treatment. Clin dermatol, 22: 429- 433.
• Dreno, B., Moyse, D., Alirezai, M., Amblard, P., Auffret, N., Beylot, C. ve diğerleri. (2001). Multicenter randomized comparative double blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. Dermatology, 203(2): 135-140.
• Emiroğlu, N., Cengiz, F. & Kemeriz, F. (2015). İnsülin resistance in severe acne vulgaris. Postep Derm Alergol, 32(4): 281-285.
• El-Akawi, Z., Abdel-Latif, N. & Abdul-Razzak, K. (2006). Does the plasma level of vitamins A and E affect acne condition? Clin Exp Dermatol, 31(3): 430-4.
• Garner, S.E. (2003). Evidence-based Dermatology. İçinde Williams H, Bigby M, Diepgen T, Herxheimer A, Naldi L, Rzany B (Eds.), Acne Vulgaris (pp. 87-115.). London: BMJ Publishing Group,
• Gollnick, H. P.M., Zouboulis, C. C., Akamatsu, H., Kurokawa, I. & Schulte, A. (1991), Pathogenesis and Pathogenesis Related Treatment of Acne. The Journal of Dermatology, 18(9): 489–499. doi:10.1111/j.1346-8138.1991.tb03122.
• Goulden, V., Stables, G.I. & Cunliffe, W.J. (1999). Prevalence of facial acne in adults. J Am Acad Dermatol, 41(4): 577-580.
• Im, M., Kim, S.Y., Sohn, K.C., Choi, D.K., Lee, Y., Seo, Y.J. ve diğerleri. (2012). Epigallocatechin-3-gallate suppresses IGF-I-induced lipogenesis and cytokine expression in SZ95 sebocytes. J Invest Dermatol, 132(12): 2700–2708.
• James, M., Gibson, R.A.& Cleland, L.G. (2000). Dietary polyunsaturated fatty acids and inflammatory mediator production. Am JClin Nutr,71 : 43–348.
• Jappe, U. (2003). Pathological Mechanism of Acne with Special Emphasis on Propionibacterium acnes and Related Therapy. Acta Derm Venereol , 83(4): 241-248.
• Jarrousse,V., Castex-Rizzi, N., Khammari, A., Charveron, M. & Dreno, B. (2007 ). Zinc salts inhibit in vitro Toll-like receptor 2 surface expression by keratinocytes. European Journal of Dermatology, 17(6): 492–496. doı:10.1684/ejd.2007.0263.
• Jung, J.Y., Yoon, M.Y., Min, S., Hong, J.S., Choi, Y.S. & Suh, D.H. (2010). The influence of dietary patterns on acne vulgaris in Koreans. Eur J Dermatol, 20(6): 1-5.
• Jung, M.K., Ha, S., Son, J.A., Song, J.H., Houh, Y., Cho, E., ve diğerleri. (2012). Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1/2 pathway. Arch Dermatol Res, 304(8): 655–663.
• Kaaks, R., Bellati, C., Venturelli, E., Rinaldi, S., Secreto, G., Biessy, C. ve diğerleri. (2003).Effects of dietary intervention on IGF-1 and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial. Eur J Clin Nutr, 57(9): 1079–1088.
• Kim, J., Ko, Y., Park, Y., Kim, N., Ha, W. & Cho, Y. (2010). Dietary effect of lactoferrin- enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrıtıon journal, 26: 902-909.
• LaRosa, C.L., Quach, K.A., Koons, K., Kunsalman, A.R., Zhu, J., Thiboutot, D.M. ve diğerleri (2016) . Consumption of dairy in teenagers with and without acne. J Am Acad Dermatol, 75(2): 318-322.
• Li, Z., Summanen, P.H., Downes, J., Corbett, K., Komoriya, T., Henning, S.M. ve diğerleri. (2015). Antimicrobial activity of pomegranate and green tea extract on propionibacterium acnes, propionibacterium granulosum, staphylococcus aureus and staphylococcus epidermidis. J. Drugs Dermatol, 14(6): 574–578.
• Lim,S., Quon, M.J. & Kon Koh, K.(2014). Modulatıon of adiponectin as a potential therapeutic strategy. Atherosclerosis, 233: 721-728.
• Ling, J.M.L. & Schryvers, A.B. (2006). Perspectives on interactions between lactoferrin and bacteria. Biochem Cell Biol, 84(3): 275-281.
• Loh, B.I., Sathyasuryan, D.R. & Mohamed, H.J. (2013). Plasma adiponectin concentrations are associated with dietary glycemic index in Malaysian patients with type 2 diabetes. Asia Pac J Clin Nutr, 22(2): 241-248.
• Mahmood, T., Akhtar, N., Khan, B.A., Khan, H.M. & Saeed, T. (2010). Outcomes of 3% green tea emulsion on skin sebum production in male volunteers. Bosn J Basic Med Sci, 10(3): 260–264.
• Makrantonaki, E., Ganceviciene, R. & Zouboulis, C. (2011). An update on the role of the sebaceous gland in the pathogenesis of acne. Dermato-Endocrinology 3(1): 41-49.
• Mariana,A.H.S., Hussam,A.H., Eugen,V.C., Nicolet,T., Hamida, A.H., Adriana, C. ve diğerleri (2016). Diet, Smoking and Family History as Potential Risk Factors in Acne Vulgaris – a Community-Based Study. Acta Medica Marisiensis, 62(2): 173-181.
• Melnik, B.C. & Schmitz, G. (2009). Role of insulin, insulin-like growth factor-1, hyperglycemic food and milk consumption in the pathogenesis of acne vulgaris. Exp Dermatol, 18(10): 833-841.
• Melnik, B.C., Schmitz, G. & Zouboulis, C. (2009). Anti-acne agents attenuate FGFR2 signal transduction in acne. J Invest Dermatol, 129(8): 1868-1877.
• Melnik, B.C. (2013). Biocative Dietary Factors and Plant Extracts in Dermatology. İçinde Watson, R.R. ve Zibadi, S.(Eds). Western-diet mediated mTORC1 signaling in acne, psoria¬sis, atopic dermatitis, and related disorders of civilization: therapeutic role of plant-derived natural mTORC1 inhibitors (pp. 397–419). New York: Springer Science & Business Media,
• Melnik, B.C. & Zouboulis, CC. (2013). Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Exp Dermatol, 22: 311–315.
• Muthu, M., Gopal, J., Min, S.X. & Chun, S. (2016). Green tea versus traditional Korean teas: Antibacterial/antifungal or both? Appl. Biochem. Biotechnol, 180(4): 780–790.
• Nasiri, S., Ghalamkarpour, F., Yousefi, M. & Sadighha, A. (2009). Serum zinc levels in Iranian patients with acne. Clin Exp Dermatol, 34(7): 446.
• Okoro, E.O., Ogunbiyi, A.O., George, A.O. & Subulade, M.O. (2016). Association of diet with acne vulgaris among adolescents in Ibadan, southwest Nigeria. International Journal of Dermatology, 55(9): 982–988.
• OyetakinWhite, P., Tribout, H. & Baron, E. (2012). Protective mechanisms of green tea polyphenols in skin. Oxid. Med. Cell. Longev., 2012: 1-8.
• Ozuguz, P., Dogruk Kacar, S.,Ekiz, Ö., Takci, Z., Balta, İ. & Kalkan, G. (2014). Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol, 33(2): 99–102.
• Phuaklee, P., Ruangnoo, S. & Itharat, A. (2012). Anti-inflammatory and antioxidant activities of extracts from Musa sapientum peel. J Med Assoc Thai, 95(1): 142–146.
• Rigopoulos, D., Gregoriou, S., İfandi, A., Efstathiou, G. Georgala, S., Chalkias, J. ve diğerleri (2007). Coping with acne: beliefs and perceptıons in a sample of secondary school Greek pupıls. Journal Euro Academic Dermodel Venereol, 21: 806-10.
• Rubin, M., Kim, K. & Logan, A. (2008). Acne vulgaris, mental health and omega-3 fatty acids: A report of cases. Lipids Health Dis, 7(36): 1-5.
• Sahib, A.S., Al-Anbari, H.H. & Raghif, A.R.A. (2013). Oxidative stress in acne vulgaris: an important therapeutic target. J Mol Pathophysiol, 3(1): 27–31.
• Saleh, B.O., Anbar, Z.N. & Majid, A.Y. (2013). Role of some trace elements in pathogenesis and severity of acne vulgaris in Iraqi male patients. J Clin Exp Dermatol Res, 46(2): 98–106.
• Sies, H. & Stahl, W. (2004). Nutritional protection against skin damage from sunlight. Annu. Rev. Nutr, 24: 173–200.
• Smith, R.N., Mann, N.J., Braue, A., Makelainen, H. & Varigos, G.A. (2007). A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial. Am J Clin Nutr, 86(1): 107-115.
• Smith, R.N., Brave, A., Varigos, G. & Mann, N. (2008). The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerid. Journal of Dermatological Science, 50(1): 41-52.
• Spencer, E.H., Ferdowsian, H.R. & Barnard, N.D. (2009). Diet and acne: a review of the evidence. Int J Dermatol, 48(4): 339-347.
• Szyszkowska B, Łepecka-Klusek C, Kozłowicz K, Jazienicka, I. & Krasowska, D. (2014). The influence of selected ingredients of dietary supplements on skin condition. Postep Derm Alergol, 31(3): 174-81.
• Tan, J.K., Vasey, K. & Yung, K.F. (2001). Beliefs and perceptions of patients with acne. J Am Acad Dermatol, 44(3): 439–445.
• Taylor, M., Ganzoloz, M. & Foster,P. (2011). Pathways to inflammatıon; acne pathophysilogy. Eur J Dermatol, 21(3): 323-333. doi: 10.1684/ejd.2011.1357.
• Tenaud, I., Khamaria, A. & Dreno, B. (2007). In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions. Experimental Dermatology, 16(6): 500–506.
• Wei, B., Pang, Y., Zhu, H., Qu, L., Xiao, T. Wei, H.C. ve diğerleri (2010). The epidemiology of adolescent acne in North East China. J Eur Acad Dermatol Venereol, 24(8): 953-957.
• Van Aller, G.S., Carson, J.D., Tang, W., Peng, H., Zhao, L.,Copeland, R.A. ve diğerleri. (2011). Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor. Biochem Biophys Res Commun, 406(2): 194–199.
• Yoon, J.Y., Kwon, H.H., Min, S.U., Thiboutot, D.M. & Suh, D.H. (2013). Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular tar¬gets and inhibiting P. acnes. J Invest Dermatol, 133(2): 429–440.
• Zouboulis, C.C. (2004). Acne and sebaceous gland function. Clin Dermatol, 22: 360–366.