Current Approaches in Wound Healing: Role of Macro Nutrients

Year 2019, Volume: 6 Issue: 1, 1 - 16, 26.04.2019

Duygu Pekmezci , Aslı Akyol Mutlu

https://doi.org/10.21020/husbfd.426731

Abstract

A large body of evidence have shown that undernutrition
affects wound healing, negatively. In order to clarify the complete role of
nutrition in wound healing,  the steps of
wound healing and the nutrients that act on these steps should be evaluated.
Protein is the most underlined nutrient at wound healing because of its utilisation
at every phase of wound healing. Along with protein, omega 3 fatty acids are
stated to be precursors of some mediators which take active role at
inflammation resolving phase and therefore contribute to wound healing by
inhibiting chronic inflammation. Carbonhydrates promotes wound healing indirectly
by taking part in glycoproteins like hyaluronan and lactoferrin. In this
review, the mechanisms by which macro-nutrients used in wound healing influence
the healing process is discussed.

Keywords

wound healing, nutrition

Yara İyileşmesinde Güncel Yaklaşımlar: Makro Besin Ögelerinin Rolü

Abstract

Yetersiz beslenmenin yara iyileşmesini olumsuz yönde etkilediğini gösteren
pek çok çalışma vardır. Ancak, yara iyileşmesinde beslenmenin rolünün tam
olarak açıklanabilmesi için yara iyileşmesi fizyolojisinin aşamaları ve bu
aşamalarda rol oynayan besin ögelerinin her boyutuyla değerlendirilmesi gereklidir.
Protein, yara iyileşmesinin her aşamasında kullanıldığı için yara iyileşmesi
üzerinde en fazla durulan besin ögesidir. Bunun yanı sıra, omega 3 yağ
asitlerinin inflamasyonun çözülme aşamasında aktif rol oynayan bazı maddelerin
öncüsü olduğu ve kronik inflamasyonu önleyerek yara iyileşmesini desteklediği belirtilmektedir.
Karbonhidratlar ise, dolaylı olarak laktoferrin ve hiyaluronan gibi
glikoproteinlerin yapısına katılarak, yara iyileşmesine katkıda
bulunabilmektedir. Bu derlemede yara iyileşmesinde kullanılan makro besin
ögelerinin iyileşme sürecine hangi mekanizmalarla etki ettiğinden bahsedilmiştir.  

Keywords

yara iyileşmesi, beslenme

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