Harran Üniversitesi Tıp Fakültesi Dergisi

1304-9623 1309-4025

Harran University

10.35440/hutfd.1297729

Clinical Sciences

Klinik Tıp Bilimleri

Effect of Fluid Balance on Oxidant and Antioxidant Balance During Cardiopulmoner Bypass

Kardiyopulmoner Bypass’ta Sıvı Dengesinin Oksidan ve Antioksidan Denge Üzerine Etkisi

https://orcid.org/0000-0002-7531-4958

Korkmaz Ersöz

Ezhar

HARRAN ÜNİVERSİTESİ

https://orcid.org/0000-0002-6652-6035

Aydın

Mehmet Salih

HARRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ

https://orcid.org/0000-0003-3874-8762

Koçarslan

Aydemir

ANTALYA AKEV ÜNİVERSİTESİ, SÜREKLİ EĞİTİM UYGULAMA VE ARAŞTIRMA MERKEZİ

https://orcid.org/0000-0003-0871-7842

Kafaf Yazar

Lütfiye

UNIVERSITY OF HEALTH SCIENCES, ŞANLIURFA MEHMET AKİF İNAN HEALTH RESEARCH CENTER

https://orcid.org/0000-0002-4427-8149

Hacanlı

Yasemin

HARRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ

https://orcid.org/0000-0003-0733-2318

Yazar

Mehmet

SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ŞANLIURFA MEHMET AKİF İNAN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ

08 31 2023

20 2 446 450 05 16 2023 08 01 2023

2004

Journal of Harran University Medical Faculty

Background: We aim to contribute to open heart surgery by revealing how different fluids used as prime solution during Cardiopulmonary Bypass (CPB) affect oxidative stress.Materials and Methods: A total of 30 patients, 21 men and 9 women, who underwent open heart surgery for various reasons were included in this study. Patients according to the prime solutions used 1. Group: Lactic Ringer was divided into two groups as 2 Groups: Isolyte S. A total of 4 blood samples were taken from these patients after anesthesia induction, after cross-clamping during CPB, on the 1st day and the 5th day after the operation. Total antioxidant stress (TAS), total oxida-tive stress (TOS) and oxidative stress index (OSSI) were studied from the samples taken. The results were evaluated statistically.Results: Samples collected in this study were compared before prime solution (before CPB) and after CPB. In the group using Ringer Lactate (RL) on the 5th day postoperatively, the TOS value was statistically significantly lower than the preoperative period (p=0.015). Again, when the OSI values were compared, it was seen that the OSI value of the Ringer Lactate (RL) group was statisti-cally significantly lower (p=0.032).Conclusions: As a result of our study, it was seen that the TOS and OSI values of the two types of prime solutions (Ringer Lactate and Isolayt S) frequently used during Cardiopulmonary Bypass (CPB) were lower in the Ringer Lactate (RL) group and superior in the Isolayt S group.

Amaç: Kardiyopulmoner Bypass (KPB) sırasında prime solüsyonu olarak kullanılan farklı sıvıların oksidatif stresi nasıl etkilediğini ortaya koyarak açık kalp cerrahisine katkı sağlamayı amaçlıyoruz.Yöntem: Bu çalışmaya çeşitli nedenlerle açık kalp ameliyatı geçiren 21 erkek ve 9 kadın olmak üzere toplam 30 hasta dahil edildi. Hastalar kullanılan prime solüsyonlarına göre 1. Grup: Laktatlı Ringer, 2 Grup: Isolyte S olarak iki gruba ayrıldı. Bu hastalardan anestezi indüksiyonu sonrası, KPB sırasında cross-klemp takıldıktan sonra, ameliyat sonrası 1. gün ve 5. gün olmak üzere toplam 4 kan alındı. Alınan numunelerden total antioksidan stres (TAS), total oksidatif stres (TOS) ve oksidatif stres indeksi (OSİ) çalışıldı. Sonuçlar istatistiksel olarak değerlendirildi.Materyal ve Metod: Bu çalışmada toplanan numuneler prime solüsyonu verilmeden önce (KPB önce) ve KPB’ dan sonrası karşılaştırıldı. Postoperatif 5. gün Ringer Laktat (RL) kullanan grupta TOS değeri preoperatif döneme göre istatistiksel olarak anlamlı derecede düşüktü (p=0,015). Yine OSİ değerleri karşılaştırıldığında Ringer Laktat (RL) grubunun OSİ değerinin istatistiksel olarak anlamlı derecede daha düşük olduğu görüldü (p=0,032).Sonuç: Çalışmamızın sonucunda Kardiyopulmoner Bypass (KPB) sırasında sıklıkla kullanılan iki tip prime solüsyonun (Ringer Laktat ve İsolayt S) TOS ve OSI değerlerinin Ringer Laktat (RL) grubunda daha düşük, Isolayt S grubundan daha üstün olduğu görüldü.Aim: We aim to contribute to open heart surgery by revealing how different fluids used as prime solution during Cardiopulmonary Bypass (CPB) affect oxidative stress.Material and Methods: A total of 30 patients, 21 men and 9 women, who underwent open heart surgery for various reasons were included in this study. Patients according to the prime solutions used 1. Group: Lactic Ringer was divided into two groups as 2 Groups: Isolyte S. A total of 4 blood samples were taken from these patients after anesthesia induction, after cross-clamping during CPB, on the 1st day and the 5th day after the operation. Total antioxidant stress (TAS), total oxidative stress (TOS) and oxidative stress index (OSSI) were studied from the samples taken. The results were evaluated statistically.Results: Samples collected in this study were compared before prime solution (before CPB) and after CPB. In the group using Ringer Lactate (RL) on the 5th day postoperatively, the TOS value was statistically significantly lower than the preoperative period (p=0.015). Again, when the OSI values were compared, it was seen that the OSI value of the Ringer Lactate (RL) group was statistically significantly lower (p=0.032).Conclusions: As a result of our study, it was seen that the TOS and OSI values of the two types of prime solutions (Ringer Lactate and Isolayt S) frequently used during Cardiopulmonary Bypass (CPB) were lower in the Ringer Lactate (RL) group and superior in the Isolayt S group.

Kardiyopulmoner Bypass sıvı Dengesi Oksidan ve Antioksidan Denge Prime Solüsyonu Cardiopulmonary Bypass Fluid Balance Oxidant and Antioxidant Balance Prime Solution

Harran Üniversitesi BAP birimi Araştırma Fonu Saymanlığı tarafından

15146

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