Harran Üniversitesi Tıp Fakültesi Dergisi

1304-9623 1309-4025

Harran University

10.35440/hutfd.1617126

Medical Pharmacology

Tıbbi Farmakoloji

NMDA Antagonistleri mi Venlafaksin mi Zorlu Yüzme Testinde Daha Etkili?

Are NMDA Antagonists or Venlafaxine More Effective in the Forced Swimming Test?

https://orcid.org/0000-0002-5917-3729

İnal

Ahmet

Erciyes Üniversitesi Tıp Fakültesi Tıbbi Farmakoloji Anabilim Dalı

https://orcid.org/0000-0002-9277-1333

Erenmemişoğlu

Aydın

Erciyes Üniversitesi Tıp Fakültesi Tıbbi Farmakoloji Anabilim Dalı

06 27 2025

22 2 233 238 01 13 2025 04 29 2025

2004

Journal of Harran University Medical Faculty

Amaç: Bu çalışmada NMDA antagonistlerinin (çinko sülfat, amantadin ve folik asit) antidepresan benzeri etkilerinin venlafaksin ile karşılaştırılması amaçlanmıştır.Materyal ve Metod: Deneylerde doksan altı Swiss Albino erkek fare kullanıldı ve deney grupları-na ayrıldı. Hayvanların depresyon benzeri davranışlarını test etmek amacıyla zorlu yüzme testi yapıldı. İlaçların lokomotor aktivite üzerindeki etkileri açık alan testi kullanılarak ölçüldü.Bulgular: Venlafaksin, folik asit veya çinko sülfat tek başına uygulandığında aralarında deneysel depresyon modelinde fark bulunmadı. Kombinasyon halinde uygulandığında en yüksek antidep-resan benzeri etki çinko sülfat-amantadin kombinasyonunda ve çinko sülfat-amantadin-folik asit kombinasyonunda gözlendi. Venlafaksin ve folik asit birlikte uygulandığında antidepresan benze-ri etki diğer venlafaksin kombinasyonlarına göre daha fazlaydı.Sonuç: Bu kombinasyonların depresyon tedavisinde kullanılması antidepresan etkinliğin artışı açısından önemlidir.

Background: The aim of this study is to compare the antidepressant-like effects of NMDA anta-gonists (zinc sulfate, amantadine, and folic acid) with venlafaxine.Materials and Methods: Ninety-six male Swiss Albino mice were used in the experiments and divided into experimental groups. To assess depression-like behaviors in the animals, the forced swim test was performed. The effects of the drugs on locomotor activity were measured using the open field test.Results: No differences were found between venlafaxine, folic acid, or zinc sulfate when admi-nistered alone in the experimental depression model. When administered in combination, the highest antidepressant-like effect was observed in the zinc-amantadine combination and the zinc sulfate-amantadine-folic acid combination. When venlafaxine and folic acid were adminis-tered together, the antidepressant-like effect was greater compared to other venlafaxine com-binations.Conclusions: The use of these combinations in the treatment of depression is important for the enhancement of antidepressant efficacy.

Amantadine Folic acid Depression NMDA Zinc venlafaxine

Amantadin Folik asit Depresyon NMDA Çinko venlafaksin

The Scientific Research Projects Unit of Erciyes University

TT-06-35

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