Harran Üniversitesi Tıp Fakültesi Dergisi

1304-9623 1309-4025

Harran University

10.35440/hutfd.471717

Clinical Sciences

Klinik Tıp Bilimleri

The effect of antenatal magnesium sulphate administration on patent ductus arteriozus in very low birth weight preterms

Çok düşük doğum ağırlıklı prematürelerde antenatal magnezyum sülfat kullanımının patent duktus arteriozusa etkisi

https://orcid.org/0000-0002-9409-185X

Çakır

Ufuk

https://orcid.org/0000-0002-9970-0714

Tayman

Cüneyt

08 29 2019

16 2 213 217 10 17 2018 05 15 2019

2004

Journal of Harran University Medical Faculty

Background: The prevalence of patent ductus arteriosus (PDA) is inverselyproportional to gestational age and birth weight, and may lead to manypremature morbidities and mortality. There are contradictory results regardingthe fact that magnesium sulphate (MgSO4), that is used as tocolytic inpremature labor, increases the frequency of PDA. In our study, we aimed todetermine the effect of antenatal MgSO4 application on haemodynamicallysignificant PDA (hsPDA) in very low birth weight (VLBW; <1500g) premature infants.Methods:We retrospectively evaluated the medical records of VLBW preterm infants withvery low birth weight (VLBW; <1500g) between January 2013 and December2016.The demographic and clinical characteristics of the infants were recorded.The preterms included in the study were divided into two groups as with hsPDAand without hsPDA. Demographic, clinical features and MgSO4 administration werecompared between two groups.Results:A total of 602 VLBW infans were included. 257 (42.7%) infants had hsPDA, and 11(1.8%) infants with hsPDA had PDA ligation due to being unresponsive to medicaltreatment. The rate of administration of antenatal MgSO4 in the hsPDA group was61.8% (n = 159), and the rate of antenatal MgSO4 administration in thenon-hsPDA group was found to be statistically significant (31.6%) (n = 109) (p<0.001).Conclusions: In our study, the rate of antenatal MgSO4 administration andpremature morbidities were found to be higher in the hsPDA group than infantswithout hsPDA.Keywords:Hemodynamically significant patent ductus arteriosus, premature, very low birthweight, magnesium sulfate

Amaç: Patent duktus arteriozus (PDA) sıklığı, gebelik haftası ve doğumağırlığıyla ters orantılıdır ve birçok prematüre morbiditesine ve mortalitesineneden olabilir. Erken eyleminde tokolitik olarak kullanılan magnezyum sülfatın(MgSO4) PDA sıklığını artırdığıyla ilgili çelişkili sonuçlar vardır.Çalışmamızda çok düşük doğum ağırlıklı (ÇDDA; <1500g) prematürelerdeantenatal MgSO4 uygulanmasının hemodinamik anlamlı PDA’nın (haPDA) üzerine etkisinibelirlenmesi amaçlanmıştır. Materyal vemetod: Çalışmamızda Ocak 2013ile Aralık 2016 tarihleri arasında ünitemizde izlenen, ÇDDA bebeklerretrospektif olarak incelendi. Bebeklerin demografik ve klinik özelliklerikayıt edildi. Çalışmaya dahil edilen prematürelerin haPDA’sı olan ve olmayanlarolarak iki gruba ayrılarak, demografik, klinik özellikleri ve MgSO4 uygulanmasıaçından karşılaştırıldı. Bulgular: Toplam 602 ÇDDA bebeğin dahil edildiği çalışmamızda, 257 bebekte(%42,7) haPDA saptandı ve 11 bebeğe (%1,8) PDA ligasyonu uygulandı. Hemodinamikanlamlı PDA grubunda antenatal MgSO4 uygulanma oranı %61,8 (n=159), haPDAolmayan gruptaki antenatal MgSO4 uygulanma oranına %31,6 (n=109) göreistatistiksel olarak anlamlı yüksek olarak tespit edildi (p<0,001). Sonuç: Çalışmamızda ÇDDA’lı bebeklerde haPDA grubunda antenatal MgSO4kullanım oranı ve prematüre morbiditeleri daha yüksek olarak bulundu. Anahtarkelimeler: Hemodinamik anlamlıpatent duktus arteriozus, prematüre, çok düşük doğum ağırlığı, magnezyum sülfat

Hemodinamik anlamlı patent duktus arteriozus prematüre çok düşük doğum ağırlığı magnezyum sülfat

Hemodynamically significant patent ductus arteriosus premature very low birth weight magnesium sulfate

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