Approach to Acute Phase Reactions in the Aspects of Pathology and General Situation in Turkey

Year 2022, Volume: 11 Issue: 1, 132 - 138, 15.05.2022

Belma Dayı , Alper Sevimli

https://doi.org/10.31196/huvfd.1099981

Abstract

This review evaluates the importance of acute phase proteins (APP) and acute phase reaction (APR), which are accepted as sensitive biomarkers in diagnosing of animal diseases, both in general and pathological terms, with a particular emphasis on the situation in Turkey. Pathological examinations have been extensively used in studies investigating the APP and APR in veterinary medicine globally. In contrast, the number of studies and pathology involvement is limited in Turkey. For this reason, we conducted a qualitative and quantitative analysis of the studies in the world and in Turkey to emphasize the importance of the subject and increase awareness among the clinicians. The review is the first comprehensive report on the subject in Turkey and is supported by a regional map of the distribution of performed studies.

Keywords

Acute phase protein, acute phase reaction, C-reactive protein, haptoglobin, secondary amyloidosis, serum amyloid-A

Thanks

We thank Assoc. Prof. Dr. Taci Cangül for his scientific help.

Akut Faz Reaksiyonlarına Patoloji Açısından Yaklaşım ve Türkiye’deki Genel Durum

Abstract

Bu derleme, hayvanlarda hastalıkların teşhisinde duyarlı biyobelirteçler olarak kabul edilen akut faz proteinleri (AFP) ve akut faz reaksiyonunun (AFY) hem genel hem de patolojik açıdan önemini Türkiye'deki duruma özel bir vurgu yaparak değerlendirmektedir. Patolojik incelemeler, dünya çapında veteriner hekimlik alanında AFP’leri ve AFY'yi araştıran çalışmalarda yaygın olarak kullanılmaktadır. Buna karşılık Türkiye'de, hem çalışma sayısı hem de patolojinin katılımı sınırlıdır. Bu nedenle konunun önemini vurgulamak ve klinisyenlerin farkındalığını arttırmak için dünyada ve Türkiye'de yapılan çalışmaların nitel ve nicel bir analizini yaptık. Bu derleme, Türkiye'de konuyla ilgili yapılan ilk kapsamlı çalışmadır ve yapılan çalışmaların dağılımının bölgesel bir haritası ile desteklenmektedir.

Keywords

Akut faz protein, akut faz yanıt, C-reaktif protein, haptoglobin, sekonder amiloidozis, serum amiloid A

References

• Akgul G, Akgul MB, Ozen D, Demirbilek SK, 2018: Comparison of serum procalcitonin, haptoglobin and C-reactive protein levels in goats with Corynebacterium pseudotuberculosis. Indian J of Anim Res, 52, 1778-1781.
• Anonim (1), https://biruni.tuik.gov.tr/ilgosterge/?locale=tr, Accessed; 20.03.2022
• Arslan A, Kırmızıgül AH, 2020: Serum amyloid-A, haptoglobin and ceruloplasmin levels in dogs infected with Sarcoptes canis. Atatürk Univ Vet Bil Derg, 15, 1-6.
• Asci H, Ozmen O, Erzurumlu Y, Sofu A, Icten P, Kaynak M, 2019: Agomelatine protects heart and aorta against lipopolysaccharide-induced cardiovascular toxicity via inhibition of NF-kβ phosphorylation. Drug Chem Toxicol, 13, 1-10.
• Atmaca HT, Gazyagci AN, Terzi OS, Dincel GC, Sumer T, 2019: Tracking acute phase protein response during acute and chronic Toxoplasma gondii infection. Lab Anim Res, 35, 1-9.
• Balikci E, Al M, 2014: Some serum acute phase proteins and immunoglobulins concentrations in calves with rotavirus, coronavirus, E. coli F5 and Eimeria species. Iran J Vet Res, 15, 397-401.
• Bayramli G, Ulutas B, 2008: Acute phase protein response in dogs with experimentally induced gastric mucosal injury. Vet Clin Pathol, 37, 312-316.
• Bochsler PN, Slauson DO, 2002: Inflammation and repair of tissue. In: Mechanisms of Disease. A Textbook of Comparative General Pathology, Slauson DO, Cooper BJ (Eds), 223-225, Mosby, St Louis, USA.
• Bozukluhan K, Merhan O, Büyük F, Çelebi Ö, Gökçe G, 2016: Determination of some acute phase proteins level in cattle with brucellosis. Ankara Univ Vet Fak Derg, 63, 13-16.
• Bozukluhan K, Merhan O, Gökçe Hİ, Öğün M, Atakişi E, Kızıltepe Ş, Gökçe G, 2018: Determination of some acute phase proteins, biochemical parameters and oxidative stress in sheep with naturally infected sheeppox virus. Kafkas Univ Vet Fak Derg, 24, 437-441.
• Ceciliani F, Ceron JJ, Eckersall PD, Sauerwein H, 2012: Acute phase proteins in ruminants. J Proteomics, 75, 4207-4231.
• Ceciliani F, Giordano A, Spagnolo V, 2002: The systemic reaction during inflammation: the acute-phase proteins. Protein Pept Lett, 9, 211-223.
• Ceron JJ, Eckersall D, Martinez-Subiela S, 2005: Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol, 34, 85-99.
• Denizhan V, Kozat S, Yilmaz AB, 2019: Investigation of serum amyloid A, haptoglobin and fibrinogen levels in sheep infected with Fasciola hepatica. J Livest Sci, 10, 53-58.
• Dinler C, Ulutas B, Voyvoda H, Ulutas PA, Ural K, Karagenc T, 2017: Haptoglobin and serum amyloid-A concentrations and their relationship with oocyst count in neonatal lambs experimentally infected with Cryptosporidium parvum. Vet Parasitol, 247, 49-56.
• Dörtkardeş AB, Şahinduran Ş, 2020: Determination of serum amyloid A, haptoglobin and hepcidin levels in calves with endemic viral pneumonia. Ankara Univ Vet Fak Derg, 67, 127-131.
• Eckersal PD, 2000: Recent advances and future prospects for the use of acute phase proteins as markers of disease in animals. Rev Med Vet, 151, 577-584.
• Enginler SO, Ateş A, Sığırcı BD, Sontaş BH, Sönmez K, Karaçam E, Ekici H, Dal GE, Gürel A, 2014: Measurement of C-reactive protein and prostaglandin F2α metabolite concentrations in differentiation of canine pyometra and cystic endometrial hyperplasia/mucometra. Reprod Domest Anim, 49, 641-647.
• Ferreira RF, Dittrich RL, Zimmermann IB, Ljubic BB, Mrljak V, Eckersall PD, 2021: Differential acute-phase protein responses in dogs seropositive or seronegative for Neospora caninum. Parasitol Res, 120, 3529-3535.
• Halıgur M, Ozmen O, 2011: Immunohistochemical detection of serum amyloid-A, serum amyloid-P, C-reactive protein, tumour necrosis factor-α and TNF-α receptor in sheep and goat pneumonias. Rev Med Vet, 162, 475-481.
• Hedia M, Ibrahim S, Mahmoud K, Ahmed Y, Ismail S, Belely ME, 2021: Hemodynamic changes in cytokines, chemokines, acute phase proteins and prostaglandins in mares with subclinical endometritis. Theriogenol, 171, 38-4.
• Issi M, Gül Y, Başbuğ O, Ulutaş PA, 2017: Haptoglobin, serum amyloid A and ceruloplasmin concentrations in cattle with suspicion of coryza gangrenosa bovum. Vet Arh, 87, 703-712.
• Kocaturk M, Martinez S, Eralp O, Tvarijonaviciute A, Ceron J, Yılmaz Z, 2010: Prognostic value of serum acute-phase proteins in dogs with parvoviral enteritis. J Small Anim Pract, 51, 478-483.
• Kumar V, Abbas AK, Aster JC, 2014: Robbins Basic Pathology. 9 th ed., Elsevier, Philadelphia, USA.
• Mallick S, Subramaniam S, Biswal JK, Ranjan R, Mohapatra JK, Sahoo AP, 2021: Short communication: preliminary observations on the serum levels of HSP70 and its correlation with serum cortisol, thyroid hormones, and acute-phase protein concentration in cattle naturally infected with foot-and-mouth disease virus. Trop Anim Health Prod, 53: 1-5.
• Mohammadi S, Mohammadi V, Esmaeilnejad B, 2021: Evaluation of some acute phase proteins in cattle naturally infected with Babesia bigemina. Comp Immunol Microbiol Infect Dis, 76, 1-4.
• Murata H, Shimada N, Yoshioka M, 2004: Current research on acute phase proteins in veterinary diagnosis: an overview. Vet J, 168, 28-40.
• Nakamura M, Takahashi M, Ohno K, Koshino A, Nakashima K, Setoguchi A, Fujino Y, Tsujimoto H, 2008: C-reactive protein concentration in dogs with various diseases. Clin Pathol, 70, 127-131.
• Sahinduran S, Albay MK, Karakurum MC, Ozmen O, Kale M, 2016: Investigation of some cytokines, acute phase proteinse and hepcidin levels before and after treatment in dogs with parvoviral gastroenteritis. Pak Vet J, 36, 487-492.
• Sahinduran S, Kale M, Kıyıcı R, Sevgisunar NS, 2017: Some acute phase proteins and hepcidin levels in single and dual infection with BVD and BHV-1. MAKÜ Sag Bil Enst Derg, 5, 115-123.
• Salem NY, Saeed HA, Farag HS, Ghandour RA, 2020: Canine demodicosis: hematological and biochemical alterations. Vet World, 13, 68-72.
• Saril A, Kocaturk M, Shimada K, Uemura A, Akgün E, Levent P, Baykal AT, Prieto AM, Agudelo CF, Tanaka R, Ceron JJ, Koch J, Yilmaz Z, 2022: Serum proteomic changes in dogs with different stages of chronic heart failure. Anim, 12, 2-14.
• Sevimli A, Bülbül T, Bülbül A, Yağcı A, 2013: Chicken amyloid arthropathy: serum amyloid A, interleukin-1β, interleukin-6, tumour necrosis factor-α and nitric oxide profile in acute phase (12th hour). Pol J Vet Sci, 16, 241-247.
• Sevimli A, Mısırlıoğlu D, Yağcı A, Bülbül A, Yılmaztepe A, Altunbas K, 2008: The role of chicken IL-1β, IL-6 and TNF-α in the occurrence of amyloid arthropathy. Vet Res Commun, 32, 499-508.
• Sevimli A, Sevimli FK, Şeker E, Ulucan A, Demirel HH, 2015: Acute-phase responses in cattle infected with hydatid cysts and microbial agents. J Helminthol, 89, 471-479.
• Sevimli A, Yalcin M, Cangul IT, Aydin S, 2012: Investigation of serum amino acid and serum amyloid A concentrations in chickens with amyloid arthropathy. Vet Q, 52, 17-23.
• Tuna GE, 2015: Sağlıklı ve farklı hastalıklı kedilerde serum akut faz protein konsantrasyonlarının araştırılması. PhD, ADÜ Sağlık Bilimleri Enstitüsü, Aydın.
• Ulutaş PA, Voyvoda H, Ulutaş B, Aypak S, 2008: Haptoglobin, serum amyloid-A and ceruloplasmin concentrations in goats with mixed helminth infection. Turkiye Parazitol Derg, 32, 229-233.