Ranunculaceae Dermatitis due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey

Ebru Çelik; Ebru Okyay; Filiz Ertekın

Research Article

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Ranunculaceae Dermatitis due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey

Year 2020, Volume: 12 Issue: 1, 1 - 11, 29.06.2020

Ebru Çelik , Ebru Okyay , Filiz Ertekın

Abstract

Magistral drugs prepared with plants in nature have been used all over the world for centuries to treat various diseases. However, besides the benefits expected from plants, unexpected side effects can also be encountered. Irritant contact dermatitis is one of the dermatosis that these plants can cause. Ranunculaceae species are used in conditions such as rheumatic diseases, hemorrhoids, wound healing, abscesses, psoriasis. In the literature, there are reported cases of irritant contact dermatitis depending on various species of the Ranunculaceae family. Here, we present three cases of irritant contact dermatitis, which have been used as an antirheumatic in the traditional treatment and Ranunculaceae family (Buttercup, Mayflower) depending on the topical use of Ranunculus arvensis species and, to make the compilation literature of cases reported from Turkey.

Keywords

Ranunculaceae Dermatitis, Ranunculus Arvensis, Buttercup, irritant contact dermatitis

Thanks

We are grateful to the Hasan Serdar Turkmen, MD for his cooperation.

References

1. McGovern TW. Dermatose Due to Plants. In: Bolognia JL, Schaffer VJ, Cerroni L, eds. Dermatology. 4th Edition. Philadelphia, Elsevier, 2018: 17,286.
2. Sasseville D. Phytodermatitis. J Cutan Med Surg. 1999;3(5):263-279.
3. Stoner JG, Rasmussen JE. Plant dermatitis. J Am Acad Dermato1. 1983; 9:1-15.
4. Davis PH. Flora of Turkey and the East Aegean Islands. Edinburgh University Pres, 1965:172-174.
5. Metin A, Calka O, Akdeniz N, Behcet L. Phytodermatitis from Ceratocephalus falcatus. Contact Dermatitis. 2005;52:314-316.
6. Tanker N, Koyuncu M, Coskun M. Farmasötik botanik. Ankara Üniversitesi Eczacılık Fakültesi yayınları no. 78, Ankara 1998: 222-229.
7. Turner N J. Counter-irritant and other medicinal uses of plants in Ranunculaceae by native peoples in British Columbia and neighbouring areas. J Ethnopharmacol. 1984;11:181-201.
8. Baytop T. Theraphy with Medicinal Plants in Turkey (Past and Present), 2nd Edition. Nobel Tıp Kitabevi, Istanbul. 1999.
9. Gürhan G, Ezer N. Plants used for hemorrhoid treatment in folk medicine I. Hacettepe University Journal of the Faculty of Pharmacy. 2004;24:37-55.
10. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines. A guide for health-care professionals. The Pharmaceutical Press, London. 1996:296.
11. Sezik E, Yesilada E, Honda G, Takaishi Y, Takeda Y, Tanaka T. Traditional medicine in Turkey. X. Folk medicine in Central Anatolia. Journal of Ethnopharmacology. 2001;75:95-115.
12. Cao BJ, Meng QY. Analgesic and anti-inflammatory effects of Ranunculus japonicus extract. Planta Medica. 1992;58:496-498.
13. Barbour EK, Sharif MA, Sagherian AN, Habre RS, Talhouk SN. Screening of selected indigenous plants of Lebanon for antimicrobial activity. Journal of Ethnopharmacology. 2004;93:1-7.
14. Li H, Zhou C, Pan Y, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and R. sceleratus. Planta Medica. 2005;71:1128-1133.
15. Hao DC, Xiao PG, Ma HY, Peng Y, He CN. Mining chemodiversity from biodiversity: pharmacophy logeny of medicinal plants of Ranunculaceae. Chin J Nat Med. 2015;13(7):507-520.
16. Akkol EK, Suntar I, Erdogan TF, Keles H, Gonenc TM, Kıvcak B. Wound healing and anti-inflammatory properties of Ranunculus pedatus and Ranunculus constantinapolitanus: A comparative study. Journal of Ethnopharmacology. 2012;139:478-484.
17. Li RZ, Pei HP, Ji XJ. Antimutagenic activity and metabolic transformation of ranunculin by rat liver microsomes. Yao Xue Xue Bao. 1993;28(7):481-485.
18. Li RZ, Ji XJ. The cytotoxicity and action mechanism of ranunculin in vitro. Yao Xue Xue Bao. 1993;28(5):326-331.
19. Marston A, Cabo M, Lubrano C. Clarification of the saponin composition of Ranunculus ficaria tubers. Natural Product Communications. 2006;1:27-32.
20. Liang Y, Chen Z, Liu L. Studies on chemical constituents of Ranunculus japonicus. Zhongguo Zhongyao Zazhi. 2008;33:2201-2203.
21. Wegner C, Hamburger M. Tensioactive compounds from the aquatic plant Ranunculus fluitans L. (Ranunculaceae). Helvetica Chimica Acta. 2000;83:1454-1464.
22. Zhang L, Yang Z, Tian JK. Two new indolopyridoquinazoline alkaloidal glycosides from Ranunculus ternatus. Chemical & Pharmaceutical Bulletin. 2007;55:1267-1269.
23. Chi Y, Yang Y, Yu S. Effect and composition of organic acid of Radix ranunculus ternati. Nanjing Zhongyiyao Daxue Xuebao. 2007;23:365-367.
24. Burbach J. The blistering effect of buttercups. Ned T Geneesk. 1963; 107:1128-1130.
25. Eskitascioglu T, Dogan F, Sahin G, et al. An extraordinary chemical burn injury cause: buttercup, a report of five cases. Burns. 2008; 34:727-730.
26. Yenidunya MO, Can Z, Demirseren ME. A burn from a plant. Plast Reconstr Surg. 1999;103(1):335-336.
27. Oztas P, Gur G, Senlik B, Yalcin B, Polat M, Tamer E, et al. Phytocontact dermatitis due to Ranunculus illyricus: Two cases. J Eur Acad Dermatol Venereol. 2006; 20:1372-1373.
28. Güner A. Ranunculus L. In: Güner A, Özhatay N, Ekim T, Baser KHC, eds. Flora of Turkey and East Aegean Islands Supplement 2, vol. 11. Edinburgh University Press, Edinburgh, 2000:14.
29. Davis PH. Ranunculus L. (Ranunculaceae). In: Davis PH, ed. Flora of Turkey and the East Aegeaen Islands Supplement , vol. 10. Edinburgh Univ. Press, Edinburgh, 1988:18-22, 231.
30. Polat M, Oztas P, Yalcin B, Tamer E, Gur G, Alli N. Contact dermatitis due to Allivum sativum and Ranunculus illyricus: two cases. Contact Dermatitis. 2007;57(4):279-280.
31. Ozkol HU, Calka O, Akdeniz N, Pinar SM. Phytodermatitis in eastern Turkey: a retrospective, observational study. Dermatitis. 2014;25(3):140-146.
32. Akbulut S, Semur H, Kose O, et al. Phytocontact dermatitis due to Ranunculus arvensis mimicking burn injury: report of three cases and literature review. Int J Emerg Med. 2011;21:4-7.
33. Metin A, Calka O, Behçet L, Yildirim E. Phytodermatitis from Ranunculus damascenus. Contact Dermatitis. 2000;44(3):183.
34. Emsen MI. İlginç ve öldürücü bitki kökenli olan buttercup (Ranunculus: Düğün Çiçeği) yanığı. Türk Plastik Rekonstr Est Cer Derg. 2006;14(2):142-143.
35. Kose R, Okur MI, Bingol I, Cetin H. Phytocontact dermatitis mimicking a burn injury due to Ranunculus constantinopolitanus. Contact Dermatitis. 2008;59(4):249-250.
36. Orak M, Ustundag M, Guloglu C, Tas M, Baylan B. A skin burn associated with Panunculus arvensis. Indian J Dermatol. 2009;54:19-20.
37. Calka O, Akdeniz N, Uce HO, Karadag AS, Behcet L. Irritant contact dermatitis caused by Ranunculus kotschyi Boiss in 6 cases. Contact Dermatitis. 2011;64:158-184.
38. Albayrak Y, Albayrak A, Melikoglu M, Kordali S. Chemical burn caused by Ranunculus arvensis. Wounds. 2011;23(3):E6-E8.
39. Turan H, Sarici M, Turan A. Irritant phytocontact dermatitis due to buttercup (ranunculaceae) in geriatric patient. Turkish Journal of Geriatrics. 2012;15(4):476-478.
40. Uçmak D, Ayhan E, Akkurt MZ, et al. Presentation of three cases with phyto contact dermatitis caused by Ranunculus and Anthemis genera. J Dermatolog Treat. 2014;25:467-469.
41. Elmas O, Kızılyel O, Metin MS, Bilen H, Atasoy M. Phyto Contact Dermatitis Caused by Ranunculus Damascenus: A Case Report. Kafkas J Med Sci. 2015;5(3):120-122. 42. Kocak AO, Sarıtemur M, Atac K, Guclu S, Ozlu I. A rare chemical burn due to Ranunculus arvensis: three case reports. Ann Saudi Med. 2016;36(1):89-91.
43. An I, Ucmak D, Esen M, Gevher OD. Phytocontact dermatitis due to Ranunculus arvensis: Report of three cases. North Clin Istanb. 2019;6(1):81-84.
44. Sayhan MB, Gokdemir MT, Guloglu C, Orak M, Ustundag M. A Burn case associated with Ranunculus arvensis. Anatol J clin Investig. 2009;3(1):85-87.
45. Degirmenci E, Duman N, Mat A, Bavunoglu I, Ikizceli I, Aktas C. Phytocontact Dermatitis: A Case Study. Journal of Academic Emergency Medicine Case Reports. 2015;6(3):66-68.
46. Benli AR, Oruc MA, Erturhan S, Sunay D. Irritant phytocontact dermatitis caused by buttercup at various times: A series of three patients. Eur J Gen Med. 2018;15(1):43-46.
47. Karaca S, Kulac M, Kucuker H. Phytodermatitis caused by Ceratocephalus falcatus (Ranunculaceae). Eur J Dermatol. 2005;15(5):404-405.
48. Polat M. A case of phytodermatitis due to Ranunculus arvensis used as an herbal remedy. Int J Dermatol. 2016;55: e37–8.

Year 2020, Volume: 12 Issue: 1, 1 - 11, 29.06.2020

Ebru Çelik , Ebru Okyay , Filiz Ertekın

Abstract

References

1. McGovern TW. Dermatose Due to Plants. In: Bolognia JL, Schaffer VJ, Cerroni L, eds. Dermatology. 4th Edition. Philadelphia, Elsevier, 2018: 17,286.
2. Sasseville D. Phytodermatitis. J Cutan Med Surg. 1999;3(5):263-279.
3. Stoner JG, Rasmussen JE. Plant dermatitis. J Am Acad Dermato1. 1983; 9:1-15.
4. Davis PH. Flora of Turkey and the East Aegean Islands. Edinburgh University Pres, 1965:172-174.
5. Metin A, Calka O, Akdeniz N, Behcet L. Phytodermatitis from Ceratocephalus falcatus. Contact Dermatitis. 2005;52:314-316.
6. Tanker N, Koyuncu M, Coskun M. Farmasötik botanik. Ankara Üniversitesi Eczacılık Fakültesi yayınları no. 78, Ankara 1998: 222-229.
7. Turner N J. Counter-irritant and other medicinal uses of plants in Ranunculaceae by native peoples in British Columbia and neighbouring areas. J Ethnopharmacol. 1984;11:181-201.
8. Baytop T. Theraphy with Medicinal Plants in Turkey (Past and Present), 2nd Edition. Nobel Tıp Kitabevi, Istanbul. 1999.
9. Gürhan G, Ezer N. Plants used for hemorrhoid treatment in folk medicine I. Hacettepe University Journal of the Faculty of Pharmacy. 2004;24:37-55.
10. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines. A guide for health-care professionals. The Pharmaceutical Press, London. 1996:296.
11. Sezik E, Yesilada E, Honda G, Takaishi Y, Takeda Y, Tanaka T. Traditional medicine in Turkey. X. Folk medicine in Central Anatolia. Journal of Ethnopharmacology. 2001;75:95-115.
12. Cao BJ, Meng QY. Analgesic and anti-inflammatory effects of Ranunculus japonicus extract. Planta Medica. 1992;58:496-498.
13. Barbour EK, Sharif MA, Sagherian AN, Habre RS, Talhouk SN. Screening of selected indigenous plants of Lebanon for antimicrobial activity. Journal of Ethnopharmacology. 2004;93:1-7.
14. Li H, Zhou C, Pan Y, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and R. sceleratus. Planta Medica. 2005;71:1128-1133.
15. Hao DC, Xiao PG, Ma HY, Peng Y, He CN. Mining chemodiversity from biodiversity: pharmacophy logeny of medicinal plants of Ranunculaceae. Chin J Nat Med. 2015;13(7):507-520.
16. Akkol EK, Suntar I, Erdogan TF, Keles H, Gonenc TM, Kıvcak B. Wound healing and anti-inflammatory properties of Ranunculus pedatus and Ranunculus constantinapolitanus: A comparative study. Journal of Ethnopharmacology. 2012;139:478-484.
17. Li RZ, Pei HP, Ji XJ. Antimutagenic activity and metabolic transformation of ranunculin by rat liver microsomes. Yao Xue Xue Bao. 1993;28(7):481-485.
18. Li RZ, Ji XJ. The cytotoxicity and action mechanism of ranunculin in vitro. Yao Xue Xue Bao. 1993;28(5):326-331.
19. Marston A, Cabo M, Lubrano C. Clarification of the saponin composition of Ranunculus ficaria tubers. Natural Product Communications. 2006;1:27-32.
20. Liang Y, Chen Z, Liu L. Studies on chemical constituents of Ranunculus japonicus. Zhongguo Zhongyao Zazhi. 2008;33:2201-2203.
21. Wegner C, Hamburger M. Tensioactive compounds from the aquatic plant Ranunculus fluitans L. (Ranunculaceae). Helvetica Chimica Acta. 2000;83:1454-1464.
22. Zhang L, Yang Z, Tian JK. Two new indolopyridoquinazoline alkaloidal glycosides from Ranunculus ternatus. Chemical & Pharmaceutical Bulletin. 2007;55:1267-1269.
23. Chi Y, Yang Y, Yu S. Effect and composition of organic acid of Radix ranunculus ternati. Nanjing Zhongyiyao Daxue Xuebao. 2007;23:365-367.
24. Burbach J. The blistering effect of buttercups. Ned T Geneesk. 1963; 107:1128-1130.
25. Eskitascioglu T, Dogan F, Sahin G, et al. An extraordinary chemical burn injury cause: buttercup, a report of five cases. Burns. 2008; 34:727-730.
26. Yenidunya MO, Can Z, Demirseren ME. A burn from a plant. Plast Reconstr Surg. 1999;103(1):335-336.
27. Oztas P, Gur G, Senlik B, Yalcin B, Polat M, Tamer E, et al. Phytocontact dermatitis due to Ranunculus illyricus: Two cases. J Eur Acad Dermatol Venereol. 2006; 20:1372-1373.
28. Güner A. Ranunculus L. In: Güner A, Özhatay N, Ekim T, Baser KHC, eds. Flora of Turkey and East Aegean Islands Supplement 2, vol. 11. Edinburgh University Press, Edinburgh, 2000:14.
29. Davis PH. Ranunculus L. (Ranunculaceae). In: Davis PH, ed. Flora of Turkey and the East Aegeaen Islands Supplement , vol. 10. Edinburgh Univ. Press, Edinburgh, 1988:18-22, 231.
30. Polat M, Oztas P, Yalcin B, Tamer E, Gur G, Alli N. Contact dermatitis due to Allivum sativum and Ranunculus illyricus: two cases. Contact Dermatitis. 2007;57(4):279-280.
31. Ozkol HU, Calka O, Akdeniz N, Pinar SM. Phytodermatitis in eastern Turkey: a retrospective, observational study. Dermatitis. 2014;25(3):140-146.
32. Akbulut S, Semur H, Kose O, et al. Phytocontact dermatitis due to Ranunculus arvensis mimicking burn injury: report of three cases and literature review. Int J Emerg Med. 2011;21:4-7.
33. Metin A, Calka O, Behçet L, Yildirim E. Phytodermatitis from Ranunculus damascenus. Contact Dermatitis. 2000;44(3):183.
34. Emsen MI. İlginç ve öldürücü bitki kökenli olan buttercup (Ranunculus: Düğün Çiçeği) yanığı. Türk Plastik Rekonstr Est Cer Derg. 2006;14(2):142-143.
35. Kose R, Okur MI, Bingol I, Cetin H. Phytocontact dermatitis mimicking a burn injury due to Ranunculus constantinopolitanus. Contact Dermatitis. 2008;59(4):249-250.
36. Orak M, Ustundag M, Guloglu C, Tas M, Baylan B. A skin burn associated with Panunculus arvensis. Indian J Dermatol. 2009;54:19-20.
37. Calka O, Akdeniz N, Uce HO, Karadag AS, Behcet L. Irritant contact dermatitis caused by Ranunculus kotschyi Boiss in 6 cases. Contact Dermatitis. 2011;64:158-184.
38. Albayrak Y, Albayrak A, Melikoglu M, Kordali S. Chemical burn caused by Ranunculus arvensis. Wounds. 2011;23(3):E6-E8.
39. Turan H, Sarici M, Turan A. Irritant phytocontact dermatitis due to buttercup (ranunculaceae) in geriatric patient. Turkish Journal of Geriatrics. 2012;15(4):476-478.
40. Uçmak D, Ayhan E, Akkurt MZ, et al. Presentation of three cases with phyto contact dermatitis caused by Ranunculus and Anthemis genera. J Dermatolog Treat. 2014;25:467-469.
41. Elmas O, Kızılyel O, Metin MS, Bilen H, Atasoy M. Phyto Contact Dermatitis Caused by Ranunculus Damascenus: A Case Report. Kafkas J Med Sci. 2015;5(3):120-122. 42. Kocak AO, Sarıtemur M, Atac K, Guclu S, Ozlu I. A rare chemical burn due to Ranunculus arvensis: three case reports. Ann Saudi Med. 2016;36(1):89-91.
43. An I, Ucmak D, Esen M, Gevher OD. Phytocontact dermatitis due to Ranunculus arvensis: Report of three cases. North Clin Istanb. 2019;6(1):81-84.
44. Sayhan MB, Gokdemir MT, Guloglu C, Orak M, Ustundag M. A Burn case associated with Ranunculus arvensis. Anatol J clin Investig. 2009;3(1):85-87.
45. Degirmenci E, Duman N, Mat A, Bavunoglu I, Ikizceli I, Aktas C. Phytocontact Dermatitis: A Case Study. Journal of Academic Emergency Medicine Case Reports. 2015;6(3):66-68.
46. Benli AR, Oruc MA, Erturhan S, Sunay D. Irritant phytocontact dermatitis caused by buttercup at various times: A series of three patients. Eur J Gen Med. 2018;15(1):43-46.
47. Karaca S, Kulac M, Kucuker H. Phytodermatitis caused by Ceratocephalus falcatus (Ranunculaceae). Eur J Dermatol. 2005;15(5):404-405.
48. Polat M. A case of phytodermatitis due to Ranunculus arvensis used as an herbal remedy. Int J Dermatol. 2016;55: e37–8.

There are 47 citations in total.

Details

Primary Language	English
Subjects	Internal Diseases
Journal Section	Research
Authors	Ebru Çelik 0000-0003-0985-7396 Ebru Okyay 0000-0001-6155-1787 Filiz Ertekın This is me 0000-0002-3919-3554
Publication Date	June 29, 2020
Published in Issue	Year 2020 Volume: 12 Issue: 1

Cite

APA	Çelik, E., Okyay, E., & Ertekın, F. (2020). Ranunculaceae Dermatitis due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey. International Archives of Medical Research, 12(1), 1-11.
AMA	Çelik E, Okyay E, Ertekın F. Ranunculaceae Dermatitis due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey. IAMR. June 2020;12(1):1-11.
Chicago	Çelik, Ebru, Ebru Okyay, and Filiz Ertekın. “Ranunculaceae Dermatitis Due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey”. International Archives of Medical Research 12, no. 1 (June 2020): 1-11.
EndNote	Çelik E, Okyay E, Ertekın F (June 1, 2020) Ranunculaceae Dermatitis due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey. International Archives of Medical Research 12 1 1–11.
IEEE	E. Çelik, E. Okyay, and F. Ertekın, “Ranunculaceae Dermatitis due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey”, IAMR, vol. 12, no. 1, pp. 1–11, 2020.
ISNAD	Çelik, Ebru et al. “Ranunculaceae Dermatitis Due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey”. International Archives of Medical Research 12/1 (June 2020), 1-11.
JAMA	Çelik E, Okyay E, Ertekın F. Ranunculaceae Dermatitis due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey. IAMR. 2020;12:1–11.
MLA	Çelik, Ebru et al. “Ranunculaceae Dermatitis Due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey”. International Archives of Medical Research, vol. 12, no. 1, 2020, pp. 1-11.
Vancouver	Çelik E, Okyay E, Ertekın F. Ranunculaceae Dermatitis due to Ranunculus Arvensis: Case Series, Literature Review of Reported Cases from Turkey. IAMR. 2020;12(1):1-11.

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