Abstract
Radyasyonun sebep olduğu s arkomlar nadir görülen geç komplikasyonlardır. Genellikle tedaviden 5-10 yıl sonra gelişir. Radyasyonun yol açtığı solid tümörlerin Hodgkin hastalığı, meme kanseri ve prostat kanseri tedavisi için radyoterapi alan hastalarda görüldüğü rapor edilmiştir. Bununla birlikte akciğer kanserinin radyoterapi ile tedavisinin ardından gelişen sarkom vakaları literatürde sayılıdır. Skuamöz hücreli akciğer karsinomu tanısı ile pnömonektomi ameliyatı yapılmış, radyoterapi uygulanan ve bu tedaviden 15 yıl sonra sağ omuz ağrısı ile başvuran hastanın, bilgisayarlı toraks tomografisinde pnömonektomi lojunda kalsifiye kitle lezyon saptandı. Transtorasik true-cut biyopsi sonucu sarkom olarak rapor edildi. Bu vakayı, pnömonektomi lojunda radyoterapiye sekonder sarkom gelişmesi ve nadir görülmesi sebebi ile yayınlamayı uygun gördük.
References
- Chapelier AR, Bacha EA, Montpreville VT, Dulmet EM, Rietjens M, Margulis A, Macchiarini P, Dartevelle PG. Radical resection of radiation- induced sarcoma of the chest wall: report 15 cases. Ann Thorac Surg.1997; 63: 214-9.
- Polgar C, Orosz Z, Szerdahelyi A, Fodor J, Major T, Magori A, Czeyda- Pommersheim F, Vamosi Nagy I, Szakolczai I, Fejös Z, Nemeth G. Postirradiation angiosarcoma of the chest wall and breast: issues of radiogenic origin, diagnosis and treatment in two cases. Oncology 2001; 60: 31-4.
- Ninomiya H, Miyoshi T, Shirakusa T, Shiraishi T, Yamamoto N, Nabeshima K. Postradiation sarcoma of the chest wall: report of two cases. Surg Today 2006; 36: 1101-4.
- Komdeur R, Hoekstra HJ, Molenaar WM, Van Den Berg E, Zwart N, Pras E, Plaza-Menacho I, Hafstra RM, Van Der Graaf WT. Clinicopatho- logic assessment of postradiation sarcomas: KIT as a potential treatment target. Clin Cancer Res 2003; 9: 2926-32.
- Sheppard DG, Libshitz HI. Post-radiation sar- comas: a review of the clinical and imaging features in 63 cases. Clin Radiol 2001; 56: 22-9.
- Mayer R, Aigner C, Stranzi H, Preidler KW, Guss H, Hacki A. Radiation-induced osteo- sarcoma of the chest wall. Breast J 2002; 8: 320-2.
- İZMİR GÖ⁄ÜS HASTANESİ DERGİSİ Yazıflma Adresi: Dr. Nesrin KIRAL
- Dr. Lütfi Kırdar Kartal Eğitim ve Arafltırma Hastanesi,
- Göğüs Hastalıkları Kliniği, İSTANBUL
- e-posta: drnesrinkiral@yahoo.com
Abstract
Radiation i nduced sa rcoma is a late and very rare complication of radiotherapy. It usually occurs 5 to 10 years following radiotherapy. Radiation induced solid tumors were reported in patients irradiated for HodgkinÕs disease, breast cancer and prostatic cancer. In addition to this, sarcoma cases were rarely reported in the literature following radiotherapy for lung cancer. The patient was admitted with complaint of right shoulder pain, 15 years after radiotherapy to pneumonectomy pouch in an surgically resected squamous cell lung cancer. On her thorax computed tomography a calcified mass lesion was detected. Transthoracic true-cut biopsy were performed and reported as sarcoma. Our case was reported as a rare sarcoma, which occurred at the pneumonectomy pouch after adjuvant radiation therapy to pneumonectomy pouch of squamous cell lung cancer.
Keywords
References
- Chapelier AR, Bacha EA, Montpreville VT, Dulmet EM, Rietjens M, Margulis A, Macchiarini P, Dartevelle PG. Radical resection of radiation- induced sarcoma of the chest wall: report 15 cases. Ann Thorac Surg.1997; 63: 214-9.
- Polgar C, Orosz Z, Szerdahelyi A, Fodor J, Major T, Magori A, Czeyda- Pommersheim F, Vamosi Nagy I, Szakolczai I, Fejös Z, Nemeth G. Postirradiation angiosarcoma of the chest wall and breast: issues of radiogenic origin, diagnosis and treatment in two cases. Oncology 2001; 60: 31-4.
- Ninomiya H, Miyoshi T, Shirakusa T, Shiraishi T, Yamamoto N, Nabeshima K. Postradiation sarcoma of the chest wall: report of two cases. Surg Today 2006; 36: 1101-4.
- Komdeur R, Hoekstra HJ, Molenaar WM, Van Den Berg E, Zwart N, Pras E, Plaza-Menacho I, Hafstra RM, Van Der Graaf WT. Clinicopatho- logic assessment of postradiation sarcomas: KIT as a potential treatment target. Clin Cancer Res 2003; 9: 2926-32.
- Sheppard DG, Libshitz HI. Post-radiation sar- comas: a review of the clinical and imaging features in 63 cases. Clin Radiol 2001; 56: 22-9.
- Mayer R, Aigner C, Stranzi H, Preidler KW, Guss H, Hacki A. Radiation-induced osteo- sarcoma of the chest wall. Breast J 2002; 8: 320-2.
- İZMİR GÖ⁄ÜS HASTANESİ DERGİSİ Yazıflma Adresi: Dr. Nesrin KIRAL
- Dr. Lütfi Kırdar Kartal Eğitim ve Arafltırma Hastanesi,
- Göğüs Hastalıkları Kliniği, İSTANBUL
- e-posta: drnesrinkiral@yahoo.com
Details
| Other ID | JA49YJ36HD |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | October 1, 2009 |
| Published in Issue | Year 2009 Volume: 23 Issue: 2 |