AĞIR ALLERJİK ASTIMDA 1 YILLIK ANTİ-IGE (OMALİZUMAB) DENEYİMİMİZ

Year 2017, Volume: 31 Issue: 3, 165 - 172, 01.12.2017

Ferda Bilgir Bilge Özdemir Papatya Değirmenci Bahadır Dede , Cengiz Kırmaz

Abstract

Amaç: Standart tedavilere yanıtsız orta ve ağır
alerjik astımda anti IgE (Omalizumab) tedavisinin
etkili ve yararlı olduğu bilinmektedir. Bu çalışmada
omalizumab tedavisi uyguladığımız alerjik astımlı
hastalarımızın verilerinin paylaşılması amaçlandı.
Yöntem ve Gereç: Kliniğimizde omalizumab
tedavisi uygulanan ağır alerjik astımlı 23 hastanın
dosya kayıtları ve bilgi formları retrospektif olarak
incelendi. Allerjen duyarlılığı deri prik testi ile
saptandı. Omalizumab tedavisi öncesi ve tedavinin
1.yılı sonundaki serum total IgE, Astım Kontrol
Testi, kullanılan ilaç sayısı, acil başvurusu, FEV1,
FEV1/FVC değerleri karşılaştırıldı.
Bulgular: Yaş ortalaması 45.78±10.71 yıl, hastalık
süresi ortalaması 13.69±9.04 yıl olan 23 hastanın
%69.6’sı kadın (n=16) idi. Astıma ek olarak
hastaların %65.2’sinde alerjik rinit, %34.8’indeürtiker, %13’ünde ilaç allerjisi, %8.7’sinde gıda
allerjisi, %4.3’ünde latex allerjisi vardı. Ev tozu
akarı duyarlılığı %78.3, ev tozu akarı + diğer
inhalan allerjen duyarlılığı %21.7 idi. Omalizumab
tedavisinin 1.yılı sonunda kullanılan astım ilaçları
sayısında, acil başvurusunda, serum total IgE ve
FEV1/FVC’de azalma (P<0.05), astım kontrol testi
puanlarında artma (P<0.05) saptandı.
Sonuç: Hastalarımızda omalizumab tedavisinin
etkili ve güvenli olduğu, iyi tolere edildiği görüldü.
Standart tedavilerle kontrol sağlanamayan ağır
alerjik astımlı hastalarda omalizumab tedavisinin
yararlı olduğunu düşünmekteyiz.

Keywords

Astım, omalizumab, allerji

OUR ANTI-IGE (OMALIZUMAB) EXPERIENCE IN SEVERE ALLERGIC ASTHMA: 1ST YEAR EXPERIENCE

Abstract

Aim: Anti-IgE (omalizumab) therapy is known to be
effective and useful in moderate to severe allergic
asthma without response to standard treatments.
This study aimed to share the data of our allergic
asthmatic patients with omalizumab treatment.
Material and Methods: The records and data
sheets of 23 patients with severe allergic asthma
who underwent omalizumab treatment were
retrospectively reviewed in our clinic. Sensitivity
to allergen was detected by skin prick test. Serum
total IgE, Astma Control Test, number of
medications used, urgent admission, FEV1, FEV1 /
FVC values were compared before and after
omalizumab treatment.
Results: The mean age was 45.78 ± 10.71 years
and the mean time of ilness of the patients were
13.69 ± 9.04 years. Of the 23 patients, 69.6% were female (n = 16). In addition to asthma,
65.2% of patients had allergic rhinitis, 34.8% had
urticaria, 13% had drug allergy, 8.7% had food
allergy, and 4.3% had latex allergies. House dust
mite sensitivities were 78.3%, house dust mite +
other inhaled allergen sensitivities were 21.7%.
The number of asthma medications, serum total
IgE and FEV1 / FVC decreased (P <0.05) andasthma
control test scores increased (P <0.05) at the end
of the 1st year of omalizumab treatment.
Conclusion:It has been shown that omalizumab
treatment is effective and safe and well tolerated
in our patients. We think that omalizumab
treatment is useful in patients with severe allergic
asthma who can not be controlled by standard
treatments.

Keywords

Asthma, omalizumab, allergy

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