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Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü

Year 2022, Issue 17, 381 - 390, 29.08.2022
https://doi.org/10.38079/igusabder.1152514

Abstract

Amaç: Meme kanseri, kadınlarda kanser kaynaklı ölümlerde akciğer kanserinden sonra ikinci sırada yer alır. Çeşitli çalışmalarda, selenoproteinlerin kanserogenezin bazı evrelerini baskıladığı ve kanser hücrelerinin çoğalma hızını azalttığı gösterilmiştir. Ancak bu mekanizmalar tam olarak açıklanamamıştır. Kanser tedavisinde radyoterapi, kemoterapiyle birlikte en çok tercih edilen tedavi yöntemlerindendir. Çalışmanın amacı, radyoterapi alan meme kanserli hastaların tedavi öncesi ve sonrası selenoprotein düzeylerindeki değişiklikleri değerlendirerek hastalığın etiyopatogenezine olası etkilerini incelemektir.
Yöntem: Çalışmamıza meme kanseri teşhisi konmuş, radyoterapi öncesi ve radyoterapi sonrası örnekleri alınan 35 kadın hasta ile herhangi bir ilaç tedavisi almayan 25 sağlıklı kadın gönüllü dahil edildi. Hasta ve sağlıklı kontrol gruplarını oluşturan bireylerden kan örnekleri alındı. Serum örneklerinde selenoprotein K (Sel-K), selenoprotein W1 (Sel-W1) ve selenoprotein P (Sel-P) düzeyleri ELISA (Enzyme-Linked Immunosorbent Assay) yöntemi ile ölçüldü. İstatistiksel analiz, Wilcoxon ve Mann-Whitney U testleri kullanılarak yapıldı. Hesaplamalar için Statistical Package for the Social Sciences – SPSS 21.0 for Windows (SPSS Inc, Chicago, IL, ABD) kullanıldı. p<0.05, istatistiksel olarak anlamlı bir farkı belirtmek için kabul edildi.
Bulgular: Serum Sel-K düzeyleri tedavi öncesi ve kontrol grubu karşılaştırıldığında, tedavi öncesi grupta anlamlı olarak düşük bulundu. Sel- P düzeyleri hem tedavi öncesi hem de tedavi sonrasında kontrol grubu ile karşılaştırıldığında her iki grupta da kontrol grubuna göre düşük bulundu. Sel-W1 düzeylerinde gruplar arasında herhangi bir anlamlılık bulunmadı.
Sonuç: Meme kanserinde bazı selenoproteinlerin hastalığın etiyopatogenezinde önemli bir rolü olmakla birlikte daha fazla örneklem grubu ve ileri çalışmalar ile hastalığın progresyonu ve selenoprotein düzeyleri arasındaki ilişkinin araştırılmasına ihtiyaç duyulmaktadır.

References

  • Harris JR, Lippman ME, Veronesi U, Willett W. Medical progress: Breast cancer. The New England Journal of Medicine. 1992;327(6):390-398. doi:10.1056/NEJM199208063270606.
  • Greenlee RT, Hill‐Harmon MB, Murray T, Thun M. Cancer statistics. CA: A Cancer. Journal for Clinicians. 2001;51(1):15-36. doi:10.3322/canjclin.51.1.15.
  • Mahata J, Basu A, Ghoshal S, Sarkar JN, Roy AK, Poddar G, et al. Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal. India. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2003;534(1-2):133-143. doi:10.1016/S1383-5718(02)00255-3.
  • Waks AG, Winer EP. Breast cancer treatment: A review. Jama. 2019;321(3):288-300. doi:10.1001/jama.2018.19323.
  • Aung KL, Siu LL. Genomically personalized therapy in head and neck cancer. Cancers of the Head & Neck. 2016;1(1):1-10. doi:10.1186/s41199-016-0004-y.
  • Maxwell KN, Nathanson KL. Common breast cancer risk variants in the post-COGS era: A comprehensive review. Breast Cancer Research. 2013;15(6): 1-17. doi:210.1186/bcr3591.
  • Brown KM, Arthur JR. Selenium, selenoproteins and human health: A review. Public health nutrition. 2001;4(2b):593-599. doi:10.1079/PHN2001143.
  • Riaz M, Mehmood KT. Selenium in human health and disease: A review. Journal of Postgraduate Medical Institute. 2012;26(2):120-134.
  • Mehdi Y, Hornick JL, Istasse L, Dufrasne I. Selenium in the environment, metabolism and involvement in body functions. Molecules. 2013;18(3):3292-3311. doi:10.3390/molecules 18033292.
  • Rayman MP. Selenoproteins and human health: Insights from epidemiological data. Biochimica et Biophysica Acta (BBA)-General Subjects. 2009;1790(11):1533-1540. doi:10.1016/j.bbagen.2009.03.014.
  • Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, et al. Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. Journal of Biological Chemistry. 2012;287(48):40414-40424. doi:10.1074/jbc.M112.421404.
  • Steinbrecher A, Méplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, et al. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a Prospective Study of European MenSelenium, SNPs, and Prostate Cancer. Cancer Epidemiology, Biomarkers & Prevention. 2010;19(11):2958-2968. doi:10.1158/1055-9965.EPI-10-0364.
  • Strauss E, Tomczak J, Staniszewski R, Oszkinis G. Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure. PloS One. 2018;13(9). doi:10.1371/journal.pone.0203350.
  • Tan L, Mai D, Zhang B, et al. PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA. Molecular Cancer. 2019;18(1):1-15. doi:10.1186/s12943-019-0940-3.
  • Ogut S, Bahtiyar N, Mordeniz C, et al. Effect of breast cancer and breast cancer treatment on the blood serum concentrations of trace elements and selenoproteins. J Elem. 2022; 27(2): 289 - 302. doi: 10.5601/jelem.2022.27.1.2216.
  • Feng JF, Lu L, Zeng P, et al. Serum total oxidant/antioxidant status and trace element levels in breast cancer patients. International Journal of Clinical Oncology. 2012;17(6):575-583. doi:10.1007/s10147-011-0327-y.
  • Gan X, Chen B, Shen Z, et al. High GPX1 expression promotes esophageal squamous cell carcinoma invasion, migration, proliferation and cisplatin-resistance but can be reduced by vitamin D. International Journal of Clinical and Experimental Medicine. 2014;7(9):2530–2540.
  • Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1-2):317-331. doi:10.1016/j.cell.2013.12.010).
  • Cox AG, Tsomides A, Kim AJ, et al. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proceedings of the National Academy of Sciences. 2016;113(38):5562-5571. doi:10.1073/pnas.1600204113.
  • El-Deeb MMK, El-Sheredy HG, Mohammed AF. The role of serum trace elements and oxidative stress in egyptian breast cancer patients. Advances in Breast Cancer Research. 2016;5(1):37-47. doi:10.4236/abcr.2016.51004.
  • Valdiglesias V, Pásaro E, Méndez J, Laffon B. In vitro evaluation of selenium genotoxic, cytotoxic, and protective effects: A review. Archives of Toxicology. 2010;84(5):337-351. doi:10. 007/s00204-009-0505-0.
  • Reeves MA, Hoffmann PR. The human selenoproteome: Recent insights into functions and regulation. Cellular and Molecular Life Sciences. 2009;66(15):2457-2478. doi:10.1007 /s00018-009-0032-4.
  • Marciel MP, Hoffmann PR. Molecular mechanisms by which selenoprotein K regulates immunity and cancer. Biological Trace Element Research. 2019;192(1):60-68. doi:10.1007 /s12011-019-01774-8.
  • Calvo A, Xiao N, Kang J, et al. Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors. Cancer Research. 2002;62(18):5325-5335.
  • Cui C, Merritt R, Fu L, Pan Z. Targeting calcium signaling in cancer therapy. Acta Pharm Sin B. 2017;7(1):3–17. doi:10.1016/j.apsb.2016.11.001.
  • Whanger PD. Selenium and its relationship to cancer: An update. British Journal of nutrition. 2004;91(1):11-28. doi:10.1079/BJN20031015.
  • Kipp AP, Frombach J, Deubel S, Brigelius-Flohé R. Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis. In Methods in Enzymology. 2013; 527:87-112. doi:10.1016/B978-0-12-405882-8.00005-2.

The Role of Some Selenoproteins in the Etiopathogenesis of Breast Cancer

Year 2022, Issue 17, 381 - 390, 29.08.2022
https://doi.org/10.38079/igusabder.1152514

Abstract

Aim: Breast cancer is the second leading cause of cancer-related deaths in women, after lung cancer. In various studies, it has been shown that selenoproteins suppress some stages of carcinogenesis and decrease the proliferation rate of cancer cells. However, these mechanisms have not been fully elucidated. Radiotherapy is one of the most preferred treatment methods along with chemotherapy in cancer treatment. This study aims to evaluate the changes in the pre- and post-treatment selenoprotein levels of breast cancer patients who received radiotherapy and to examine the effects on the etiopathogenesis of the disease.
Method: A total of 35 woman breast cancer patients and 25 healthy subjects were included in the study. Blood samples were collected from the patient group on the day prior to treatment, and on the day treatment was completed. Selenoprotein K (Sel-K), selenoprotein W1 (Sel-W1) and selenoprotein P (Sel-P) levels were measured in serum samples by ELISA (Enzyme-Linked Immunosorbent Assay) method. Statistical analysis was performed using Wilcoxon and Mann-Whitney U tests. Statistical Package for the Social Sciences – SPSS 21.0 for Windows (SPSS Inc, Chicago, IL, USA) was used for calculations. P<0.05 was accepted to indicate a statistically significant difference.
Results: Serum Sel-K levels were significantly lower in the pre-treatment group compared to the control group. When Sel-P levels in both pre- and post-treatment were compared with the control group, it was found lower Sel-P levels in both treatment groups compared to the control group. There was no significant difference between groups in Sel-W1 levels between studied groups.
Conclusions: Although some selenoproteins have an important role in the etiopathogenesis of breast cancer, more sample groups and further studies are needed to investigate the relationship between disease progression and selenoprotein levels.

References

  • Harris JR, Lippman ME, Veronesi U, Willett W. Medical progress: Breast cancer. The New England Journal of Medicine. 1992;327(6):390-398. doi:10.1056/NEJM199208063270606.
  • Greenlee RT, Hill‐Harmon MB, Murray T, Thun M. Cancer statistics. CA: A Cancer. Journal for Clinicians. 2001;51(1):15-36. doi:10.3322/canjclin.51.1.15.
  • Mahata J, Basu A, Ghoshal S, Sarkar JN, Roy AK, Poddar G, et al. Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal. India. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2003;534(1-2):133-143. doi:10.1016/S1383-5718(02)00255-3.
  • Waks AG, Winer EP. Breast cancer treatment: A review. Jama. 2019;321(3):288-300. doi:10.1001/jama.2018.19323.
  • Aung KL, Siu LL. Genomically personalized therapy in head and neck cancer. Cancers of the Head & Neck. 2016;1(1):1-10. doi:10.1186/s41199-016-0004-y.
  • Maxwell KN, Nathanson KL. Common breast cancer risk variants in the post-COGS era: A comprehensive review. Breast Cancer Research. 2013;15(6): 1-17. doi:210.1186/bcr3591.
  • Brown KM, Arthur JR. Selenium, selenoproteins and human health: A review. Public health nutrition. 2001;4(2b):593-599. doi:10.1079/PHN2001143.
  • Riaz M, Mehmood KT. Selenium in human health and disease: A review. Journal of Postgraduate Medical Institute. 2012;26(2):120-134.
  • Mehdi Y, Hornick JL, Istasse L, Dufrasne I. Selenium in the environment, metabolism and involvement in body functions. Molecules. 2013;18(3):3292-3311. doi:10.3390/molecules 18033292.
  • Rayman MP. Selenoproteins and human health: Insights from epidemiological data. Biochimica et Biophysica Acta (BBA)-General Subjects. 2009;1790(11):1533-1540. doi:10.1016/j.bbagen.2009.03.014.
  • Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, et al. Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. Journal of Biological Chemistry. 2012;287(48):40414-40424. doi:10.1074/jbc.M112.421404.
  • Steinbrecher A, Méplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, et al. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a Prospective Study of European MenSelenium, SNPs, and Prostate Cancer. Cancer Epidemiology, Biomarkers & Prevention. 2010;19(11):2958-2968. doi:10.1158/1055-9965.EPI-10-0364.
  • Strauss E, Tomczak J, Staniszewski R, Oszkinis G. Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure. PloS One. 2018;13(9). doi:10.1371/journal.pone.0203350.
  • Tan L, Mai D, Zhang B, et al. PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA. Molecular Cancer. 2019;18(1):1-15. doi:10.1186/s12943-019-0940-3.
  • Ogut S, Bahtiyar N, Mordeniz C, et al. Effect of breast cancer and breast cancer treatment on the blood serum concentrations of trace elements and selenoproteins. J Elem. 2022; 27(2): 289 - 302. doi: 10.5601/jelem.2022.27.1.2216.
  • Feng JF, Lu L, Zeng P, et al. Serum total oxidant/antioxidant status and trace element levels in breast cancer patients. International Journal of Clinical Oncology. 2012;17(6):575-583. doi:10.1007/s10147-011-0327-y.
  • Gan X, Chen B, Shen Z, et al. High GPX1 expression promotes esophageal squamous cell carcinoma invasion, migration, proliferation and cisplatin-resistance but can be reduced by vitamin D. International Journal of Clinical and Experimental Medicine. 2014;7(9):2530–2540.
  • Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1-2):317-331. doi:10.1016/j.cell.2013.12.010).
  • Cox AG, Tsomides A, Kim AJ, et al. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proceedings of the National Academy of Sciences. 2016;113(38):5562-5571. doi:10.1073/pnas.1600204113.
  • El-Deeb MMK, El-Sheredy HG, Mohammed AF. The role of serum trace elements and oxidative stress in egyptian breast cancer patients. Advances in Breast Cancer Research. 2016;5(1):37-47. doi:10.4236/abcr.2016.51004.
  • Valdiglesias V, Pásaro E, Méndez J, Laffon B. In vitro evaluation of selenium genotoxic, cytotoxic, and protective effects: A review. Archives of Toxicology. 2010;84(5):337-351. doi:10. 007/s00204-009-0505-0.
  • Reeves MA, Hoffmann PR. The human selenoproteome: Recent insights into functions and regulation. Cellular and Molecular Life Sciences. 2009;66(15):2457-2478. doi:10.1007 /s00018-009-0032-4.
  • Marciel MP, Hoffmann PR. Molecular mechanisms by which selenoprotein K regulates immunity and cancer. Biological Trace Element Research. 2019;192(1):60-68. doi:10.1007 /s12011-019-01774-8.
  • Calvo A, Xiao N, Kang J, et al. Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors. Cancer Research. 2002;62(18):5325-5335.
  • Cui C, Merritt R, Fu L, Pan Z. Targeting calcium signaling in cancer therapy. Acta Pharm Sin B. 2017;7(1):3–17. doi:10.1016/j.apsb.2016.11.001.
  • Whanger PD. Selenium and its relationship to cancer: An update. British Journal of nutrition. 2004;91(1):11-28. doi:10.1079/BJN20031015.
  • Kipp AP, Frombach J, Deubel S, Brigelius-Flohé R. Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis. In Methods in Enzymology. 2013; 527:87-112. doi:10.1016/B978-0-12-405882-8.00005-2.

Details

Primary Language Turkish
Subjects Medicine
Journal Section Articles
Authors

Selim ÖĞÜT> (Primary Author)
İSTANBUL ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ, TIP BİLİMLERİ (DR)
0000-0001-9126-6477
Türkiye


Sevgin DEĞİRMENCİOĞLU>
KIRKLARELİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI
Türkiye


Nurten BAHTİYAR>
İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, BİYOFİZİK ANABİLİM DALI
0000-0003-2420-8415
Türkiye


Fatma Behice CİNEMRE>
SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI
Türkiye


Birsen AYDEMİR>
SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, BİYOFİZİK ANABİLİM DALI
Türkiye


Didem KARAÇETİN>
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAŞAKŞEHİR ÇAM VE SAKURA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, RADYASYON ONKOLOJİSİ ANABİLİM DALI
Türkiye


Ebru HACIOSMANOĞLU This is me
BEZM-İ ÂLEM VAKIF ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ
Türkiye


Alev KURAL>
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, HAMİDİYE ULUSLARARASI TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI
0000-0003-1459-4316
Türkiye


Mehmet Emin GÜNEŞ This is me
İSTANBUL ESENYURT ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ, HEMŞİRELİK BÖLÜMÜ
Türkiye


Muhammet BEKTAŞ This is me
İSTANBUL ÜNİVERSİTESİ, TIP FAKÜLTESİ
Türkiye

Supporting Institution İstanbul Üniversitesi Bilimsel Projeler Birimi ve Sağlık Bilimleri Üniversitesi Bakırköy Sadi Konuk Eğitim ve Araştırma Hastanesi Araştırma Fonu tarafından desteklenmiştir.
Project Number TDK-2022-38056
Thanks Bu çalışma kısmen İstanbul Üniversitesi Bilimsel Projeler Birimi (Proje No: TDK-2022-38056)ve Sağlık Bilimleri Üniversitesi Bakırköy Sadi Konuk Eğitim ve Araştırma Hastanesi Araştırma Fonu tarafından desteklenmiştir.
Publication Date August 29, 2022
Published in Issue Year 2022, Volume , Issue 17

Cite

Bibtex @research article { igusabder1152514, journal = {İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi}, issn = {2536-4499}, eissn = {2602-2605}, address = {İstanbul Gelişim Üniversitesi Sağlık Bilimleri Yüksekokulu - Cihangir Mah. Şehit Jandarma Komando Er Hakan Öner Sk. No: 1 Avcılar / İstanbul / Türkiye}, publisher = {İstanbul Gelisim University}, year = {2022}, number = {17}, pages = {381 - 390}, doi = {10.38079/igusabder.1152514}, title = {Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü}, key = {cite}, author = {Öğüt, Selim and Değirmencioğlu, Sevgin and Bahtiyar, Nurten and Cinemre, Fatma Behice and Aydemir, Birsen and Karaçetin, Didem and Hacıosmanoğlu, Ebru and Kural, Alev and Güneş, Mehmet Emin and Bektaş, Muhammet} }
APA Öğüt, S. , Değirmencioğlu, S. , Bahtiyar, N. , Cinemre, F. B. , Aydemir, B. , Karaçetin, D. , Hacıosmanoğlu, E. , Kural, A. , Güneş, M. E. & Bektaş, M. (2022). Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü . İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi , (17) , 381-390 . DOI: 10.38079/igusabder.1152514
MLA Öğüt, S. , Değirmencioğlu, S. , Bahtiyar, N. , Cinemre, F. B. , Aydemir, B. , Karaçetin, D. , Hacıosmanoğlu, E. , Kural, A. , Güneş, M. E. , Bektaş, M. "Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü" . İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi (2022 ): 381-390 <https://dergipark.org.tr/en/pub/igusabder/issue/72351/1152514>
Chicago Öğüt, S. , Değirmencioğlu, S. , Bahtiyar, N. , Cinemre, F. B. , Aydemir, B. , Karaçetin, D. , Hacıosmanoğlu, E. , Kural, A. , Güneş, M. E. , Bektaş, M. "Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü". İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi (2022 ): 381-390
RIS TY - JOUR T1 - The Role of Some Selenoproteins in the Etiopathogenesis of Breast Cancer AU - SelimÖğüt, SevginDeğirmencioğlu, NurtenBahtiyar, Fatma BehiceCinemre, BirsenAydemir, DidemKaraçetin, EbruHacıosmanoğlu, AlevKural, Mehmet EminGüneş, MuhammetBektaş Y1 - 2022 PY - 2022 N1 - doi: 10.38079/igusabder.1152514 DO - 10.38079/igusabder.1152514 T2 - İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi JF - Journal JO - JOR SP - 381 EP - 390 VL - IS - 17 SN - 2536-4499-2602-2605 M3 - doi: 10.38079/igusabder.1152514 UR - https://doi.org/10.38079/igusabder.1152514 Y2 - 2022 ER -
EndNote %0 Istanbul Gelisim University Journal of Health Sciences Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü %A Selim Öğüt , Sevgin Değirmencioğlu , Nurten Bahtiyar , Fatma Behice Cinemre , Birsen Aydemir , Didem Karaçetin , Ebru Hacıosmanoğlu , Alev Kural , Mehmet Emin Güneş , Muhammet Bektaş %T Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü %D 2022 %J İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi %P 2536-4499-2602-2605 %V %N 17 %R doi: 10.38079/igusabder.1152514 %U 10.38079/igusabder.1152514
ISNAD Öğüt, Selim , Değirmencioğlu, Sevgin , Bahtiyar, Nurten , Cinemre, Fatma Behice , Aydemir, Birsen , Karaçetin, Didem , Hacıosmanoğlu, Ebru , Kural, Alev , Güneş, Mehmet Emin , Bektaş, Muhammet . "Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü". İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi / 17 (August 2022): 381-390 . https://doi.org/10.38079/igusabder.1152514
AMA Öğüt S. , Değirmencioğlu S. , Bahtiyar N. , Cinemre F. B. , Aydemir B. , Karaçetin D. , Hacıosmanoğlu E. , Kural A. , Güneş M. E. , Bektaş M. Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü. IGUSABDER. 2022; (17): 381-390.
Vancouver Öğüt S. , Değirmencioğlu S. , Bahtiyar N. , Cinemre F. B. , Aydemir B. , Karaçetin D. , Hacıosmanoğlu E. , Kural A. , Güneş M. E. , Bektaş M. Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü. İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi. 2022; (17): 381-390.
IEEE S. Öğüt , S. Değirmencioğlu , N. Bahtiyar , F. B. Cinemre , B. Aydemir , D. Karaçetin , E. Hacıosmanoğlu , A. Kural , M. E. Güneş and M. Bektaş , "Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü", İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, no. 17, pp. 381-390, Aug. 2022, doi:10.38079/igusabder.1152514

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