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MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT

Year 2021, Volume: 5 Issue: 2, 251 - 258, 31.08.2021
https://doi.org/10.46519/ij3dptdi.966777

Abstract

References

  • Elçin Y.M. “Stem Cells and Tissue Engineering”, Biomaterials. Advances in Experimental Medicine and Biology, Springer, Boston, MA. Vol. 553, 2004.
  • Vurat, M.T., Elcin, A.E. and Elcin, Y.M. “Osteogenic composite nanocoating based on nanohydroxyapatite, strontium ranelate and polycaprolactone for titanium implants”, Transactions of Nonferrous Metals Society of China, Vol. 28, Issue 9, Pages 1763-1773, 2018.
  • Parmaksiz, M., Lalegül-Ülker, Ö., Vurat, M.T., Elçin, A.E. and Elçin, Y.M. “Magneto-sensitive decellularized bone matrix with or without low frequency-pulsed electromagnetic field exposure for the healing of a critical-size bone defect”, Material Science and Engineering: C, May;124:112065. doi: 10.1016/j.msec.2021.112065. Epub 2021 Mar 26. PMID: 33947558. 2021.
  • Kang, Y., Mochizuki, N., Khademhosseini, A., Fukuda, J. and Yang, Y. “Engineering a vascularized collagen-β-tricalcium phosphate graft using an electrochemical approach”, Acta biomaterialia, Vol. 11, Pages 449-458, 2015.
  • Parmaksiz, M., Elcin, A.E. and Elcin, Y.M. “Decellularized bovine small intestinal submucosa-PCL/hydroxyapatite-based multilayer composite scaffold for hard tissue repair”, Materials Science and Engineering: C, Vol. 94, Pages 788-797, 2019.
  • Vurat, M.T., Şeker, Ş., Lalegül-Ülker, Ö., Parmaksiz, M., Elçin, A. E. and Elçin, Y.M. “Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering”, Genes & Diseases. 2020.
  • Vurat, M.T., Ergun, C., Elcin, A.E. and Elçin, Y.M. “3D Bioprinting of Tissue Models with Customized Bioinks”, In Bioinspired Biomaterials, Springer, Singapore, Pages 67-84, 2020.
  • Soufivand, A.A., Abolfathi, N., Hashemi, A. and Lee, S.J. “The effect of 3D printing on the morphological and mechanical properties of polycaprolactone filament and scaffold”, Polymers for Advanced Technologies, Vol. 31, Issue 5, Pages 1038-1046, 2020.
  • Murphy, S. and Atala, A. “3D bioprinting of tissues and organs”, Nature Biotechnology, Vol. 32, Pages 773–785, 2014.
  • She, Y., Fan, Z., Wang, L., Li, Y., Sun, W., Tang, H., Zhang, L., Wu, L., Zheng, H. and Chen, C. “3D Printed Biomimetic PCL Scaffold as framework interspersed with collagen for long segment tracheal replacement”, Frontiers in cell and developmental biology, Vol. 9, Page 33, 2021.
  • Zimmerling, A., Yazdanpanah, Z., Cooper, D.M., Johnston, J.D. and Chen, X. “3D printing PCL/nHA bone scaffolds: exploring the influence of material synthesis techniques”, Biomaterials Research, Vol. 25, Issue 1, Pages 1-12, 2021.
  • Olubamiji, A.D., Izadifar, Z., Si, J.L., Cooper, D.M., Eames, B.F. and Chen, D.X. “Modulating mechanical behaviour of 3D-printed cartilage-mimetic PCL scaffolds: influence of molecular weight and pore geometry”, Biofabrication, Vol. 8 Issue 2, Pages 025020. 2016.
  • Doyle, S.E., Henry, L., McGennisken, E., Onofrillo, C., Bella, C.D., Duchi, S., O’connell, C.D. and Pirogova, E. “Characterization of Polycaprolactone Nanohydroxyapatite Composites with Tunable Degradability Suitable for Indirect Printing”, Polymers, Vol. 13, Issue 2, Pages 295. 2021.
  • Ferreira, J., Gloria, A., Cometa, S., Coelho, J.F. and Domingos, M. “Effect of in vitro enzymatic degradation on 3D printed poly (ε-caprolactone) scaffolds: Morphological, chemical and mechanical properties”, Journal of applied biomaterials & functional materials, Vol. 15, Issue 3, Pages 185-195, 2017.
  • Cho, Y.S., Gwak, S.J. and Cho, Y.S. “Fabrication of Polycaprolactone/Nano Hydroxyapatite (PCL/nHA) 3D Scaffold with Enhanced In Vitro Cell Response via Design for Additive Manufacturing (DfAM) ”, Polymers, Vol. 13, Issue 9, Pages 1394, 2021.
  • Sodupe Ortega, E., Sanz-Garcia, A., Pernia-Espinoza, A. and Escobedo-Lucea, C. “Efficient Fabrication of Polycaprolactone Scaffolds for Printing Hybrid Tissue-Engineered Constructs”, Materials (Basel, Switzerland), Vol. 12, Issue 4, Pages 613, 2019.
  • Geng, P., Zhao, J., Wu, W., Ye, W., Wang, Y., Wang, S. and Zhang, S. “Effects of extrusion speed and printing speed on the 3D printing stability of extruded PEEK filament”, Journal of Manufacturing Processes, Vol. 37, Pages 266-273, 2019.
  • Hendrikson, W.J., Rouwkema, J., Van Blitterswijk, C.A. and Moroni, L. “Influence of PCL molecular weight on mesenchymal stromal cell differentiation”, RSC Advances, Vol. 5, Issue 67, Pages 54510-54516, 2015.

MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT

Year 2021, Volume: 5 Issue: 2, 251 - 258, 31.08.2021
https://doi.org/10.46519/ij3dptdi.966777

Abstract

Three-dimensional (3D) scaffold fabrication with appropriate architectural and mechanical properties is one of the critical components of tissue engineering. There are many traditional/conventional scaffold fabrication techniques such as electrospinning, gas foaming, freeze-drying etc. More recently, there has been increasing interest in the use of 3D printing technologies in scaffold fabrication for tissue engineering application. With the use of 3D printing technology, scaffolds with desired porosity and target damage/tissue architecture can be developed. Various 3D printing based scaffold production studies by using different types of synthetic or natural polymers are available in the literature. In the selection of polymers to be used for printing, parameters such as target scaffold mechanical properties, porosity and solubility should be considered. For example, it is well known that the molecular weights of the polymers can significantly affect the final scaffold mechanical properties. In this study, the effects of molecular weight and nozzle moving speed on the mechanical and physical properties of 3D printed scaffolds were evaluated. For this purpose, biocompatible PCL polymer with different molecular weights was used and ten-layered scaffolds were fabricated at different nozzle speeds. Then, mechanical, morphological and physical properties of the printed scaffolds were analyzed.

References

  • Elçin Y.M. “Stem Cells and Tissue Engineering”, Biomaterials. Advances in Experimental Medicine and Biology, Springer, Boston, MA. Vol. 553, 2004.
  • Vurat, M.T., Elcin, A.E. and Elcin, Y.M. “Osteogenic composite nanocoating based on nanohydroxyapatite, strontium ranelate and polycaprolactone for titanium implants”, Transactions of Nonferrous Metals Society of China, Vol. 28, Issue 9, Pages 1763-1773, 2018.
  • Parmaksiz, M., Lalegül-Ülker, Ö., Vurat, M.T., Elçin, A.E. and Elçin, Y.M. “Magneto-sensitive decellularized bone matrix with or without low frequency-pulsed electromagnetic field exposure for the healing of a critical-size bone defect”, Material Science and Engineering: C, May;124:112065. doi: 10.1016/j.msec.2021.112065. Epub 2021 Mar 26. PMID: 33947558. 2021.
  • Kang, Y., Mochizuki, N., Khademhosseini, A., Fukuda, J. and Yang, Y. “Engineering a vascularized collagen-β-tricalcium phosphate graft using an electrochemical approach”, Acta biomaterialia, Vol. 11, Pages 449-458, 2015.
  • Parmaksiz, M., Elcin, A.E. and Elcin, Y.M. “Decellularized bovine small intestinal submucosa-PCL/hydroxyapatite-based multilayer composite scaffold for hard tissue repair”, Materials Science and Engineering: C, Vol. 94, Pages 788-797, 2019.
  • Vurat, M.T., Şeker, Ş., Lalegül-Ülker, Ö., Parmaksiz, M., Elçin, A. E. and Elçin, Y.M. “Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering”, Genes & Diseases. 2020.
  • Vurat, M.T., Ergun, C., Elcin, A.E. and Elçin, Y.M. “3D Bioprinting of Tissue Models with Customized Bioinks”, In Bioinspired Biomaterials, Springer, Singapore, Pages 67-84, 2020.
  • Soufivand, A.A., Abolfathi, N., Hashemi, A. and Lee, S.J. “The effect of 3D printing on the morphological and mechanical properties of polycaprolactone filament and scaffold”, Polymers for Advanced Technologies, Vol. 31, Issue 5, Pages 1038-1046, 2020.
  • Murphy, S. and Atala, A. “3D bioprinting of tissues and organs”, Nature Biotechnology, Vol. 32, Pages 773–785, 2014.
  • She, Y., Fan, Z., Wang, L., Li, Y., Sun, W., Tang, H., Zhang, L., Wu, L., Zheng, H. and Chen, C. “3D Printed Biomimetic PCL Scaffold as framework interspersed with collagen for long segment tracheal replacement”, Frontiers in cell and developmental biology, Vol. 9, Page 33, 2021.
  • Zimmerling, A., Yazdanpanah, Z., Cooper, D.M., Johnston, J.D. and Chen, X. “3D printing PCL/nHA bone scaffolds: exploring the influence of material synthesis techniques”, Biomaterials Research, Vol. 25, Issue 1, Pages 1-12, 2021.
  • Olubamiji, A.D., Izadifar, Z., Si, J.L., Cooper, D.M., Eames, B.F. and Chen, D.X. “Modulating mechanical behaviour of 3D-printed cartilage-mimetic PCL scaffolds: influence of molecular weight and pore geometry”, Biofabrication, Vol. 8 Issue 2, Pages 025020. 2016.
  • Doyle, S.E., Henry, L., McGennisken, E., Onofrillo, C., Bella, C.D., Duchi, S., O’connell, C.D. and Pirogova, E. “Characterization of Polycaprolactone Nanohydroxyapatite Composites with Tunable Degradability Suitable for Indirect Printing”, Polymers, Vol. 13, Issue 2, Pages 295. 2021.
  • Ferreira, J., Gloria, A., Cometa, S., Coelho, J.F. and Domingos, M. “Effect of in vitro enzymatic degradation on 3D printed poly (ε-caprolactone) scaffolds: Morphological, chemical and mechanical properties”, Journal of applied biomaterials & functional materials, Vol. 15, Issue 3, Pages 185-195, 2017.
  • Cho, Y.S., Gwak, S.J. and Cho, Y.S. “Fabrication of Polycaprolactone/Nano Hydroxyapatite (PCL/nHA) 3D Scaffold with Enhanced In Vitro Cell Response via Design for Additive Manufacturing (DfAM) ”, Polymers, Vol. 13, Issue 9, Pages 1394, 2021.
  • Sodupe Ortega, E., Sanz-Garcia, A., Pernia-Espinoza, A. and Escobedo-Lucea, C. “Efficient Fabrication of Polycaprolactone Scaffolds for Printing Hybrid Tissue-Engineered Constructs”, Materials (Basel, Switzerland), Vol. 12, Issue 4, Pages 613, 2019.
  • Geng, P., Zhao, J., Wu, W., Ye, W., Wang, Y., Wang, S. and Zhang, S. “Effects of extrusion speed and printing speed on the 3D printing stability of extruded PEEK filament”, Journal of Manufacturing Processes, Vol. 37, Pages 266-273, 2019.
  • Hendrikson, W.J., Rouwkema, J., Van Blitterswijk, C.A. and Moroni, L. “Influence of PCL molecular weight on mesenchymal stromal cell differentiation”, RSC Advances, Vol. 5, Issue 67, Pages 54510-54516, 2015.
There are 18 citations in total.

Details

Primary Language English
Subjects Biomaterial
Journal Section Research Article
Authors

Murat Vurat This is me 0000-0002-8105-5841

Mahmut Parmaksız 0000-0002-4655-1401

Publication Date August 31, 2021
Submission Date July 8, 2021
Published in Issue Year 2021 Volume: 5 Issue: 2

Cite

APA Vurat, M., & Parmaksız, M. (2021). MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT. International Journal of 3D Printing Technologies and Digital Industry, 5(2), 251-258. https://doi.org/10.46519/ij3dptdi.966777
AMA Vurat M, Parmaksız M. MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT. IJ3DPTDI. August 2021;5(2):251-258. doi:10.46519/ij3dptdi.966777
Chicago Vurat, Murat, and Mahmut Parmaksız. “MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT”. International Journal of 3D Printing Technologies and Digital Industry 5, no. 2 (August 2021): 251-58. https://doi.org/10.46519/ij3dptdi.966777.
EndNote Vurat M, Parmaksız M (August 1, 2021) MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT. International Journal of 3D Printing Technologies and Digital Industry 5 2 251–258.
IEEE M. Vurat and M. Parmaksız, “MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT”, IJ3DPTDI, vol. 5, no. 2, pp. 251–258, 2021, doi: 10.46519/ij3dptdi.966777.
ISNAD Vurat, Murat - Parmaksız, Mahmut. “MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT”. International Journal of 3D Printing Technologies and Digital Industry 5/2 (August 2021), 251-258. https://doi.org/10.46519/ij3dptdi.966777.
JAMA Vurat M, Parmaksız M. MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT. IJ3DPTDI. 2021;5:251–258.
MLA Vurat, Murat and Mahmut Parmaksız. “MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT”. International Journal of 3D Printing Technologies and Digital Industry, vol. 5, no. 2, 2021, pp. 251-8, doi:10.46519/ij3dptdi.966777.
Vancouver Vurat M, Parmaksız M. MECHANICAL EVALUATION OF 3D PRINTED POLYCAPROLACTONE SCAFFOLDS: EFFECT OF MOLECULAR WEIGHT. IJ3DPTDI. 2021;5(2):251-8.

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