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            <front>

                <journal-meta>
                                                                <journal-id>hru int j dent oral res</journal-id>
            <journal-title-group>
                                                                                    <journal-title>HRU International Journal of Dentistry and Oral Research</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2792-0224</issn>
                                                                                            <publisher>
                    <publisher-name>Harran University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id/>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Dentistry</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Diş Hekimliği</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <trans-title-group xml:lang="en">
                                    <trans-title>PROBIOTICS IN PEDIATRIC DENTISTRY</trans-title>
                                </trans-title-group>
                                                                                                                                                                                                <article-title>ÇOCUK DİŞ HEKİMLİĞİNDE PROBİYOTİKLER</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-6157-2534</contrib-id>
                                                                <name>
                                    <surname>Bektaş</surname>
                                    <given-names>Özge</given-names>
                                </name>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20220825">
                    <day>08</day>
                    <month>25</month>
                    <year>2022</year>
                </pub-date>
                                        <volume>2</volume>
                                        <issue>2</issue>
                                        <fpage>116</fpage>
                                        <lpage>123</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20220609">
                        <day>06</day>
                        <month>09</month>
                        <year>2022</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20220620">
                        <day>06</day>
                        <month>20</month>
                        <year>2022</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2021, HRU International Journal of Dentistry and Oral Research</copyright-statement>
                    <copyright-year>2021</copyright-year>
                    <copyright-holder>HRU International Journal of Dentistry and Oral Research</copyright-holder>
                </permissions>
            
                                                                                                <trans-abstract xml:lang="en">
                            <p>The use of probiotic products containing live bacteria and proven health benefits is increasing today. In particular, the development of resistance of some pathogens to antibiotics brought up the need to consider shifting the treatment paradigm from specific bacterial elimination to changing bacterial ecology with probiotics, and the concept of &quot;bacteriotherapy&quot; emerged. Probiotics are dietary supplements that contain potentially beneficial microorganisms that help suppress disease-causing pathogens. Generally; probiotics have been associated with gut health, and these products are widely used for the prevention or treatment of gastrointestinal infections and diseases. However, in recent years, researchers have focused on various studies on the effects of probiotics on oral health. Although direct recommendations on the use of probiotics from the point of view of clinical practitioners have not yet been given, the scientific evidence to date suggests that probiotic therapy may be considered as an alternative approach in the field of dentistry in the future. The aim of this review is to examine the potential mechanisms of probiotic bacteria in the oral cavity, to evaluate the effects of probiotics on oral health, and to summarize the various applications of probiotic-containing products in the field of dentistry.</p></trans-abstract>
                                                                                                                                    <abstract><p>Canlı bakteri içeren ve sağlığa faydaları kanıtlanmış probiyotik ürünlerin kullanımı günümüzde artmaktadır. Özellikle bazı patojenlerin antibiyotiklere karşı direnç geliştirmesi, tedavi paradigmasını spesifik bakteri eliminasyonundan probiyotiklerle bakteri ekolojisini değiştirmeye kaydırmanın düşünülmesini gerektiğini gündeme getirmiş ve “bakteriyoterapi” kavramı ortaya çıkmştır. Probiyotikler, potansiyel olarak faydalı mikroorganizmaları içeren, hastalıklara neden olan patojenleri baskılamaya yardımcı olan diyet takviyeleridir. Genel olarak; probiyotikler bağırsak sağlığı ile ilişkilendirilmiş olup bu ürünlerin gastrointestinal enfeksiyon ve hastalıkların önlenmesi veya tedavisi için kullanımları yaygındır. Bununla birlikte, son yıllarda araştırmacılar probiyotiklerin ağız sağlığına etkilerine yönelik çeşitli çalışmalara odaklanmaktadır. Klinik pratisyenlerin bakış açısından, probiyotiklerin kullanımına ilişkin doğrudan öneriler henüz verilemese de bugüne kadar bilimsel kanıtlar, probiyotik tedavinin gelecekte diş hekimliği alanında da alternatif bir yaklaşım olarak değerlendirilebileceğini düşündürmektedir. Bu derlemenin amacı, probiyotik bakterilerin ağız boşluğundaki potansiyel mekanizmalarını incelemek, probiyotiklerin ağız sağlığna etkilerini değerlendirmek ve probiyotik içerikli ürünlerin diş hekimliği alanındaki çeşitli uygulamalarını özetlemektir.</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>probiyotikler</kwd>
                                                    <kwd>  ağız sağlığı</kwd>
                                                    <kwd>  diş hekimliği</kwd>
                                            </kwd-group>
                            
                                                <kwd-group xml:lang="en">
                                                    <kwd>probiotics</kwd>
                                                    <kwd>  oral health</kwd>
                                                    <kwd>  dentistry</kwd>
                                            </kwd-group>
                                                                                                                                        </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">1.	Cortizo, F. Probiotics And Health: A New Emerging Modality In Bio-Therapeutics. Annals of Dentistry University of Malaya 1999; 6(1), 47-51.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">2.	FAO/WHO. Guidelines for the Evaluation of Probiotics in Food. 2002, 1-11.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">3.	Schrezenmeir, J., &amp; de Vrese, M. Probiotics, prebiotics, and synbiotics—approaching a definition. The American Journal of Clinical Nutrition, 2001; 73(2), 361-364.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">4.	Parkes, G. C. An Overview of Probiotics and Prebiotics. Nursing Standard (through 2013), 21(20), 43.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">5.	Serger O, Bifidobakterium bifidum DN–173 010 içeren probiyotik meyveli yoğurt tüketen çocuklarda dental plak ve tükürükteki ağız-diş sağlığı ile ilgili bakterilerin araştırılması, Doktora Tezi, İstanbul: Yeditepe Üniversitesi Sağlık Bilimleri Enstitüsü, 2010.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">6.	Fijan, S. Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature. International Journal of Environmental Research and Public Health, 2014; 11(5), 4745-4767.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">7.	Amara, A. A., &amp; Shibl, A. Role of Probiotics in Health Improvement, Infection Control and Disease Treatment and Management. Saudi Pharmaceutical Journal, 2015; 23(2), 107-114.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">8.	Serinçay H. Tıpta Uzmanlık Eğitimi Alan Hekimlerin Probiyotikler ile İlgili Bilgi Düzeyleri ve Tutumları. Tıpta Uzmanlık Tezi, Bursa: Uludağ Üniversitesi Tıp Fakültesi Aile Hekimliği Ana Bilim Dalı, 2021.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">9.	Boyle, R. J., Robins-Browne, R. M., &amp; Tang, M. L. Probiotic Use in Clinical Practice: What are the Risks?. The American Journal of Clinical Nutrition, 2006; 83(6), 1256-1264.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">10.	Çakir, I., &amp; ÇAKMAKÇI, M. L. Probiyotikler: Tanımı, Etki Mekanizması, Seçim ve Güvenilirlik Kriterleri. GIDA, 2004; 29(6), 427-434.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">11.	Ahrne, S., Nobaek, S., Jeppsson, B., Adlerberth, I., Wold, A. E., &amp; Molin, G. The Normal Lactobacillus Flora of Healthy Human Rectal and Oral Mucosa. Journal of Applied Microbiology, 1998; 85(1), 88-94.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">12.	McGroarty, J. A., Tomeczek, L., Pond, D. G., Reid, G., &amp; Bruce, A. W. Hydrogen Peroxide Production by Lactobacillus Species: Correlation with Susceptibility to the Spermicidal Compound Nonoxynol-9. Journal of Infectious Diseases, 1992; 165(6), 1142-1144.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">13.	Kanatani, K., Oshimura, M., &amp; Sano, K. Isolation and Characterization of Acidocin A and Cloning of the Bacteriocin Gene from Lactobacillus Acidophilus. Applied and Environmental Microbiology, 1995; 61(3), 1061-1067.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">14.	S Hashem, Z., &amp; S Hashem, A. An in vitro study on the antifungal and antibiofilm activities of probiotic bacteria against Candida species isolated from orthodontic appliances and dental caries. Novel Research in Microbiology Journal, 2021; 5(2), 1176-1193.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">15.	Cui, Hai-Hong, et al. &quot;Effects of probiotic on intestinal mucosa of patients with ulcerative colitis.&quot; World Journal of Gastroenterology,  (2004); 10(10),  1521.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">16.	López-Moreno, A., &amp; Aguilera, M. Vaginal probiotics for reproductive health and related dysbiosis: systematic review and meta-analysis. Journal of clinical medicine, 2021; 10(7), 1461.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">17.	Erickson, K. L., &amp; Hubbard, N. E. Probiotic immunomodulation in health and disease. The Journal of nutrition, 2000; 130(2), 403-409.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">18.	Gungor, O. E., Kirzioglu, Z., &amp; Kivanc, M. Probiotics: can they be used to improve oral health?. Beneficial microbes, 2015; 6(5), 647-656.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">19.	Bonifait, L., Chandad, F., &amp; Grenier, D. Probiotics for oral health: myth or reality?. Journal of the Canadian Dental Association, 2009; 75(8).</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">20.	Ribeiro, F. C., et al. &quot;Action mechanisms of probiotics on Candida spp. and candidiasis prevention: an update.&quot; Journal of Applied Microbiology, 2020; 129(2), 175-185.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">21.	Twetman, S., &amp; Stecksén‐Blicks, C. Probiotics and oral health effects in children. International journal of paediatric dentistry, 2008; 18(1), 3-10.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">22.	Pujia, A. M., et al. &quot;The probiotics in dentistry: a narrative review.&quot; Eur. Rev. Med. Pharmacol. Sci, 2017; 21, 1405-1412.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">23.	Wade, W. G. The human oral microbiome. Journal of bacteriology, 2010; 192(19).</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">24.	Allaker, R. P., &amp; Ian Douglas, C. W. Non-conventional therapeutics for oral infections. Virulence, 2015; 6(3), 196-207.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">25.	Lin, T. H., Lin, C. H., &amp; Pan, T. M. The implication of probiotics in the prevention of dental caries. Applied microbiology and biotechnology, 2018; 102(2), 577-586.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">26.	Seminario-Amez, M., López-López, J., Estrugo-Devesa, A., Ayuso-Montero, R., &amp; Jané-Salas, E. Probiotics and oral health: A systematic review. Medicina oral, patologia oral y cirugia bucal, 2017; 22(3), e282.</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">27.	Hasan, N., &amp; Yang, H. Factors affecting the composition of the gut microbiota, and its modulation. PeerJ, 2019; 7, e7502.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">28.	Manji, F., Dahlen, G., &amp; Fejerskov, O. Caries and periodontitis: contesting the conventional wisdom on their aetiology. Caries Research, 2018; 52(6), 548-564.</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">29.	Keijser, B. J. F., et al. &quot;Pyrosequencing analysis of the oral microflora of healthy adults.&quot; Journal of dental research, 2008; 87(11), 1016-1020.</mixed-citation>
                    </ref>
                                    <ref id="ref30">
                        <label>30</label>
                        <mixed-citation publication-type="journal">30.	Xu, Xin, et al. &quot;Oral cavity contains distinct niches with dynamic microbial communities.&quot; Environmental microbiology, 2015; 17(3), 699-710.</mixed-citation>
                    </ref>
                                    <ref id="ref31">
                        <label>31</label>
                        <mixed-citation publication-type="journal">31.	Aas, Jørn A., et al. &quot;Bacteria of dental caries in primary and permanent teeth in children and young adults.&quot; Journal of clinical microbiology, 2008; 46(4), 1407-1417.</mixed-citation>
                    </ref>
                                    <ref id="ref32">
                        <label>32</label>
                        <mixed-citation publication-type="journal">32.	Xiao, Jin, et al. &quot;Candida albicans carriage in children with severe early childhood caries (S-ECC) and maternal relatedness.&quot; PloS one, 2016; 11(10),  e0164242.</mixed-citation>
                    </ref>
                                    <ref id="ref33">
                        <label>33</label>
                        <mixed-citation publication-type="journal">33.	Pereira, D. F. A., Seneviratne, C. J., Koga‐Ito, C. Y., &amp; Samaranayake, L. P. Is the oral fungal pathogen Candida albicans a cariogen?. Oral diseases, 2018; 24(4), 518-526.</mixed-citation>
                    </ref>
                                    <ref id="ref34">
                        <label>34</label>
                        <mixed-citation publication-type="journal">34.	Caufield, P. W., Schön, C. N., Saraithong, P., Li, Y., &amp; Argimón, S. Oral lactobacilli and dental caries: a model for niche adaptation in humans. Journal of dental research, 2015; 94(9), 110-118.</mixed-citation>
                    </ref>
                                    <ref id="ref35">
                        <label>35</label>
                        <mixed-citation publication-type="journal">35.	Sharda, S., Gupta, A., Goyal, A., &amp; Gauba, K. Remineralization potential and caries preventive efficacy of CPP-ACP/Xylitol/Ozone/Bioactive glass and topical fluoride combined therapy versus fluoride mono-therapy–a systematic review and meta-analysis. Acta Odontologica Scandinavica, 2021; 79(6), 402-417.</mixed-citation>
                    </ref>
                                    <ref id="ref36">
                        <label>36</label>
                        <mixed-citation publication-type="journal">36.	Alharith D, Alhokair R, Zakri N, Alshaqha N, Almutairi M, Alamri M. An overview of probiotic use in dentistry: a literature review. Int J Med Dev Ctries. 2021; 5(1),341-346.</mixed-citation>
                    </ref>
                                    <ref id="ref37">
                        <label>37</label>
                        <mixed-citation publication-type="journal">37.	Hedayati-Hajikand, T., Lundberg, U., Eldh, C., &amp; Twetman, S. Effect of probiotic chewing tablets on early childhood caries–a randomized controlled trial. BMC oral health, 2015; 15(1), 1-5.</mixed-citation>
                    </ref>
                                    <ref id="ref38">
                        <label>38</label>
                        <mixed-citation publication-type="journal">38.	Comelli, E. M., Guggenheim, B., Stingele, F., &amp; Neeser, J. R. Selection of dairy bacterial strains as probiotics for oral health. European journal of oral sciences, 2002; 110(3), 218-224.</mixed-citation>
                    </ref>
                                    <ref id="ref39">
                        <label>39</label>
                        <mixed-citation publication-type="journal">39.	Nikawa H et al. Lactobacillus reuteri in bovine milk fermented decreases the oral carriage of mutans streptococci. Int J Food Microbiol. 2004; 95(2), 219-223.</mixed-citation>
                    </ref>
                                    <ref id="ref40">
                        <label>40</label>
                        <mixed-citation publication-type="journal">40.	Jose JE, Padmanabhan S, Chitharanjan AB. Systemic consumption of probiotic curd and use of probiotic toothpaste to reduce Streptococcus mutans in plaque around orthodontic brackets. Am J Orthod Dentofac Orthop. 2013; 144(1), 67-72.</mixed-citation>
                    </ref>
                                    <ref id="ref41">
                        <label>41</label>
                        <mixed-citation publication-type="journal">41.	Nase L et al. Effect of Long-Term Consumption of a Probiotic Bacterium, Lactobacillus rhamnosus GG, in Milk on Dental Caries and Caries Risk in Children. Caries Res. 2001; 35(6), 412-420.</mixed-citation>
                    </ref>
                                    <ref id="ref42">
                        <label>42</label>
                        <mixed-citation publication-type="journal">42.	Reddy JJ, Sampathkumar N, Aradhya S. Probiotics in dentistry: review of the current status. Rev clín pesq odontol. 2010; 6(3), 261-267.</mixed-citation>
                    </ref>
                                    <ref id="ref43">
                        <label>43</label>
                        <mixed-citation publication-type="journal">43.	Teanpaisan R, Piwat S, Dahlén G. Inhibitory effect of oral Lactobacillus against oral pathogens. Lett Appl Microbiol. 2011; 53(4), 452-459.</mixed-citation>
                    </ref>
                                    <ref id="ref44">
                        <label>44</label>
                        <mixed-citation publication-type="journal">44.	Glavina D, Gorseta K, Skrinjarić I, Vranić DN, Mehulić K, Kozul K. Effect of LGG yoghurt on Streptococcus mutans and Lactobacillus spp. salivary counts in children. Coll Antropol. 2012; 36(1), 129-132.</mixed-citation>
                    </ref>
                                    <ref id="ref45">
                        <label>45</label>
                        <mixed-citation publication-type="journal">45.	Califano J V et al. Periodontal diseases of children and adolescents. Pediatr Dent. 2009; 31(6), 255-262.</mixed-citation>
                    </ref>
                                    <ref id="ref46">
                        <label>46</label>
                        <mixed-citation publication-type="journal">46.	Position paper: periodontal diseases of children and adolescents. Journal of Periodontology, 2003; 74(11), 1696-1704.</mixed-citation>
                    </ref>
                                    <ref id="ref47">
                        <label>47</label>
                        <mixed-citation publication-type="journal">47.	Gafan GP, Lucas VS, Roberts GJ, Petrie A, Wilson M, Spratt DA. Prevalence of periodontal pathogens in dental plaque of children. J Clin Microbiol. 2004; 42(9), 4141-4146.</mixed-citation>
                    </ref>
                                    <ref id="ref48">
                        <label>48</label>
                        <mixed-citation publication-type="journal">48.	Portela MB, Souza IPR, Costa EMMB, Hagler AN, Soares RMA, Santos ALS. Differential recovery of Candida species from subgingival sites in human immunodeficiency virus-positive and healthy children from Rio de Janeiro, Brazil. J Clin Microbiol. 2004; 42(12), 5925-5927.</mixed-citation>
                    </ref>
                                    <ref id="ref49">
                        <label>49</label>
                        <mixed-citation publication-type="journal">49.	Nguyen T, Brody H, Radaic A, Kapila Y. Probiotics for periodontal health—Current molecular findings. Periodontol 2000. 2021; 87(1), 254-267.</mixed-citation>
                    </ref>
                                    <ref id="ref50">
                        <label>50</label>
                        <mixed-citation publication-type="journal">50.	Zhao JJ, Feng XP, Zhang XL, Le KY. Effect of porphyromonas gingivalis and lactobacillus acidophilus on secretion of IL1B, IL6, and IL8 by gingival epithelial cells. Inflammation. 2012; 35(4), 1330-1337.</mixed-citation>
                    </ref>
                                    <ref id="ref51">
                        <label>51</label>
                        <mixed-citation publication-type="journal">51.	Stamatova I, Meurman JH. Probiotics: Health benefits in the mouth. Am J Dent. 2009; 22(6), 329-338.</mixed-citation>
                    </ref>
                                    <ref id="ref52">
                        <label>52</label>
                        <mixed-citation publication-type="journal">52.	Mayanagi G et al. Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria: A double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol. 2009; 36(6), 506-513.</mixed-citation>
                    </ref>
                                    <ref id="ref53">
                        <label>53</label>
                        <mixed-citation publication-type="journal">53.	Twetman S, Derawi B, Keller M, Ekstrand K, Yucel-Lindberg T, Stecksén-Blicks C. Short-term effect of chewing gums containing probiotic Lactobacillus reuteri on the levels of inflammatory mediators in gingival crevicular fluid. Acta Odontol Scand. 2009; 67(1), 19-24.</mixed-citation>
                    </ref>
                                    <ref id="ref54">
                        <label>54</label>
                        <mixed-citation publication-type="journal">54.	Iniesta M, Herrera D, Montero E, et al. Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial. J Clin Periodontol. 2012; 39(8), 736-744.</mixed-citation>
                    </ref>
                                    <ref id="ref55">
                        <label>55</label>
                        <mixed-citation publication-type="journal">55.	Mogilnicka I, Bogucki P, Ufnal M. Microbiota and Malodor — Etiology and Management. Published online 2020:1-21.</mixed-citation>
                    </ref>
                                    <ref id="ref56">
                        <label>56</label>
                        <mixed-citation publication-type="journal">56.	Hampelska K, Jaworska MM, Babalska ZŁ, Karpiński TM. The Role of Oral Microbiota in Intra-Oral Halitosis. J Clin Med. 2020; 9(8), 2484.</mixed-citation>
                    </ref>
                                    <ref id="ref57">
                        <label>57</label>
                        <mixed-citation publication-type="journal">57.	Bollen CML, Beikler T. Halitosis: the multidisciplinary approach. Int J Oral Sci. 2012; 4(2), 55-63.</mixed-citation>
                    </ref>
                                    <ref id="ref58">
                        <label>58</label>
                        <mixed-citation publication-type="journal">58.	Kazor CE, Mitchell PM, Lee AM, et al. Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients. J Clin Microbiol. 2003; 41(2), 558-563.</mixed-citation>
                    </ref>
                                    <ref id="ref59">
                        <label>59</label>
                        <mixed-citation publication-type="journal">59.	Di Pierro F. A possible probiotic (S. salivarius K12) approach to improve oral and lung microbiotas and raise defenses against SAR S-CoV-2. Minerva Med. 2020; 11(31), 281-283.</mixed-citation>
                    </ref>
                                    <ref id="ref60">
                        <label>60</label>
                        <mixed-citation publication-type="journal">60.	Hyink O, Wescombe PA, Upton M, Ragland N, Burton JP, Tagg JR. Salivaricin A2 and the novel lantibiotic salivaricin B are encoded at adjacent loci on a 190-kilobase transmissible megaplasmid in the oral probiotic strain Streptococcus salivanus K12. Appl Environ Microbiol. 2007; 73(4), 1107-1113.</mixed-citation>
                    </ref>
                                    <ref id="ref61">
                        <label>61</label>
                        <mixed-citation publication-type="journal">61.	Burton JP, Chilcott CN, Moore CJ, Speiser G, Tagg JR. A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters. J Appl Microbiol. 2006; 100(4), 754-764.</mixed-citation>
                    </ref>
                                    <ref id="ref62">
                        <label>62</label>
                        <mixed-citation publication-type="journal">62.	Burton JP, Chilcott CN, Tagg JR. The rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics. Oral Dis. 2005; 11(1), 29-31.</mixed-citation>
                    </ref>
                                    <ref id="ref63">
                        <label>63</label>
                        <mixed-citation publication-type="journal">63.	Kang M-S, Kim B-G, Chung J, Lee H-C OJ-S. Inhibitory effect of Weissella cibaria isolates on the production of volatile sulphur compounds. . J Clin Periodontol. 2006; 33, 226-232.</mixed-citation>
                    </ref>
                                    <ref id="ref64">
                        <label>64</label>
                        <mixed-citation publication-type="journal">64.	Iwamoto T, Suzuki N, Tanabe K, Takeshita T, Hirofuji T. Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: An open-label pilot trial. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2010; 110(2), 201-208.</mixed-citation>
                    </ref>
                                    <ref id="ref65">
                        <label>65</label>
                        <mixed-citation publication-type="journal">65.	Suzuki N et al. Lactobacillus salivarius WB21-containing tablets for the treatment of oral malodor: A double-blind, randomized, placebo-controlled crossover trial. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014; 117(4), 462-470.</mixed-citation>
                    </ref>
                                    <ref id="ref66">
                        <label>66</label>
                        <mixed-citation publication-type="journal">66.	Signoretto C, Burlacchini G, Faccioni F, Zanderigo M, Bozzola N, Canepari P. Support for the role of Candida spp. in extensive caries lesions of children. New Microbiol. 2009; 32(1), 101-107.</mixed-citation>
                    </ref>
                                    <ref id="ref67">
                        <label>67</label>
                        <mixed-citation publication-type="journal">67.	Torres SR, Peixoto CB, Caldas DM, et al. A prospective randomized trial to reduce oral Candida spp. colonization in patients with hyposalivation. Braz Oral Res. 2007; 21(2), 182-187.</mixed-citation>
                    </ref>
                                    <ref id="ref68">
                        <label>68</label>
                        <mixed-citation publication-type="journal">68.	Xiao J, Huang X, Alkhers N, et al. Candida albicans and Early Childhood Caries: A Systematic Review and Meta-Analysis. Caries Res. 2018; 52(1-2), 102-112.</mixed-citation>
                    </ref>
                                    <ref id="ref69">
                        <label>69</label>
                        <mixed-citation publication-type="journal">69.	Matsubara VH, Silva EG, Paula CR, Ishikawa KH, Nakamae AEM. Treatment with probiotics in experimental oral colonization by Candida albicans in murine model (DBA/2). Oral Dis. 2012; 18(3), 260-264.</mixed-citation>
                    </ref>
                                    <ref id="ref70">
                        <label>70</label>
                        <mixed-citation publication-type="journal">70.	Li D, Li Q, Liu C, et al. Efficacy and safety of probiotics in the treatment of Candida-associated stomatitis. Mycoses. 2014; 57(3), 141-146.</mixed-citation>
                    </ref>
                                    <ref id="ref71">
                        <label>71</label>
                        <mixed-citation publication-type="journal">71.	Mendonça FHBP, dos Santos SSF, de Faria I da S, Gonçalves e Silva CR, Jorge AOC, Leão MVP. Effects of probiotic bacteria on Candida presence and IgA anti-Candida in the oral cavity of elderly. Braz Dent J. 2012; 23(5), 534-538.</mixed-citation>
                    </ref>
                                    <ref id="ref72">
                        <label>72</label>
                        <mixed-citation publication-type="journal">72.	Bagan J, Sarrion G, Jimenez Y. Oral cancer: Clinical features. Oral Oncol. 2010; 46(6), 414-417.</mixed-citation>
                    </ref>
                                    <ref id="ref73">
                        <label>73</label>
                        <mixed-citation publication-type="journal">73.	Wang Y, Li J, Zhang H, et al. Probiotic Streptococcus salivarius K12 Alleviates Radiation-Induced Oral Mucositis in Mice. Front Immunol. 2021; 12(June), 1-10.</mixed-citation>
                    </ref>
                                    <ref id="ref74">
                        <label>74</label>
                        <mixed-citation publication-type="journal">74.	Cereda E, Caraccia M, Caccialanza R. Probiotics and mucositis. Curr Opin Clin Nutr Metab Care. 2018; 21(5), 399-404.</mixed-citation>
                    </ref>
                                    <ref id="ref75">
                        <label>75</label>
                        <mixed-citation publication-type="journal">75.	Asoudeh-Fard A, Barzegari A, Dehnad A, Bastani S, Golchin A, Omidi Y. Lactobacillus plantarum induces apoptosis in oral cancer KB cells through upregulation of PTEN and downregulation of MAPK signaling pathways. BioImpacts. 2017; 7(3), 193-198.</mixed-citation>
                    </ref>
                                    <ref id="ref76">
                        <label>76</label>
                        <mixed-citation publication-type="journal">76.	Narwal A. Probiotics in Dentistry – A Review. J Nutr Food Sci. 2011; 01(05), 1-5.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
