Astudy was conducted to benchmark the ground water quality parameters and itsspatial variation from Makutopora boreholes which are found 32 km from Dodomatown. A total of 90 samples (from both deep and shallow wells)were collected and analyzed for various quality parameters. The analysis results were interpolated usingstatistics and Inverse Distance Weighting tool in a Geographical InformationSystem (GIS) environment to determine their spatial variation. The results indicated that all samples were within the permissible Tanzanian standards, except for two unused production boreholes which showedhigher levels of total hardness,Electrical conductivity and total dissolved solids. However, gross pollutionwas found in community shallow wells of Chihanga and Veyula that showed high levels of nitrate (78-82 mg/l), Manganese (1.05mg/l), low pH (5.98)and E. coli. (52/100 ml). It is quite clear from this study that the groundwater supplied to Dodoma is still meeting the set drinking water standards inTanzania although aquifer deterioration was noticed which demands an urgentinnovative ground water management. The resultsobtained in this study will therefore be helpful for future monitoring andsustainable ground water quality management in the Makutopora sub basin.