AKKERMANSIA MUCINIPHILA; ,FUNCTIONAL AND PROBIOTIC PROPERTIES IN THE GASTROINTESTINAL TRACT

Year 2017, Volume: 3 Issue: 2, 29 - 35, 01.10.2017

Murat Doğan , Merve Öztağ Hilal Demirkesen Bıçak

Abstract

The development of microbial communities in the human gastrointestinal tract begins immediately after
birth. Human gut microbiota is comprised of the millions of bacterial microbial communities that are
effective in protecting the health of the host organism and share the common site with the host. At the same
time, the mucus layer formed by the epithelial cells surrounding the intestinal surface protects intestines
against intestinal external factors and meets the microbiota’s need for nutrition. It was found recently that
one of the intestinal bacteria isolated from human fecal samples, Akkermansia muciniphila, meets the need
for nutrition of itself and other bacteria by grafting to the mucus layer and providing the monomer by
degrading mucin which is the main component of mucus. Akkermansia muciniphila, which has positive
effects on human gut microbiota, decreases in microbiota in the presence of certain chronic diseases.
Recent studies have shown that decreasing amounts of Akkermansia muciniphila was also found in the
feces samples of individuals with chronic diseases such as obesity and diabetes, and as well as found in the
gastrointestinal tract, too.

Keywords

Akkermansia muciniphila, gut microbiota,, probiotic properties,, obesity, diabetes

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