Year 2017, Volume 2 , Issue 2, Pages 58 - 64 2017-12-22

EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS

Menşure Nur ÇELİK [1] , Mehtap ÜNLÜ SÖĞÜT [2]


Chemerin is a new chemotactic protein that recently joined the adipokines family. It has been shown to play a role in adipogenesis and energy metabolism, including its role on obesity, Type 2 Diabetes Mellitus (T2DM), metabolic syndrome and cardiovascular diseases. Probiotics may play role in the prevention of obesity by various mechanisms and treatment of many diseases such as T2DM. In this study, we aimed to evaluate the effects of probiotic supplementation of chemerin adipokines on serum levels and obesity markers in obese animal models. For this purpose 3 groups of experimental animals were formed. In the obtained serum samples, the effects of probiotic supplementation on chemerin and leptin level which are indicators of obesity will be examined. Weights of all the rats in the groups were weighed each week to monitor the obesity. The weight gain in the group fed with probiotic supplementation was 10,00±27,2 g for 4 weeks and the weight gain for the group fed with high fat diet was 26,200±7,085 g (p<0.05). After 8 weeks of feding the changes of BMI values of the rats were found to be statistically significant (p<0.05). There was no significant difference between the leptin values of the groups, but the difference between the mean values of the chemerin values after 12 weeks of feeding was found to be statistically significant (p <0.05). As a result; this study showed that obese rats reduced the weight gain of probiotic supplementation without calorie restriction, positive effects on BMI and chemerin adipokine serum levels. 

chemerin, leptin, obesity
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Article
Authors

Author: Menşure Nur ÇELİK
Institution: ONDOKUZ MAYIS ÜNİVERSİTESİ
Country: Turkey


Author: Mehtap ÜNLÜ SÖĞÜT
Institution: ONDOKUZ MAYIS ÜNİVERSİTESİ
Country: Turkey


Dates

Application Date : November 13, 2017
Acceptance Date : November 27, 2017
Publication Date : December 22, 2017

Bibtex @research article { ijhsrp351506, journal = {International Journal of Health Services Research and Policy}, issn = {}, eissn = {2602-3482}, address = {Dicle Üniversitesi Teknokenti Silvan Bulvarı 222/3 21280 SUR/DİYARBAKIR}, publisher = {Rojan GÜMÜŞ}, year = {2017}, volume = {2}, pages = {58 - 64}, doi = {10.23884/ijhsrp.2017.2.2.04}, title = {EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS}, key = {cite}, author = {Çeli̇k, Menşure Nur and Ünlü Söğüt, Mehtap} }
APA Çeli̇k, M , Ünlü Söğüt, M . (2017). EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS . International Journal of Health Services Research and Policy , 2 (2) , 58-64 . DOI: 10.23884/ijhsrp.2017.2.2.04
MLA Çeli̇k, M , Ünlü Söğüt, M . "EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS" . International Journal of Health Services Research and Policy 2 (2017 ): 58-64 <https://dergipark.org.tr/en/pub/ijhsrp/issue/32265/351506>
Chicago Çeli̇k, M , Ünlü Söğüt, M . "EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS". International Journal of Health Services Research and Policy 2 (2017 ): 58-64
RIS TY - JOUR T1 - EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS AU - Menşure Nur Çeli̇k , Mehtap Ünlü Söğüt Y1 - 2017 PY - 2017 N1 - doi: 10.23884/ijhsrp.2017.2.2.04 DO - 10.23884/ijhsrp.2017.2.2.04 T2 - International Journal of Health Services Research and Policy JF - Journal JO - JOR SP - 58 EP - 64 VL - 2 IS - 2 SN - -2602-3482 M3 - doi: 10.23884/ijhsrp.2017.2.2.04 UR - https://doi.org/10.23884/ijhsrp.2017.2.2.04 Y2 - 2017 ER -
EndNote %0 International Journal of Health Services Research and Policy EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS %A Menşure Nur Çeli̇k , Mehtap Ünlü Söğüt %T EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS %D 2017 %J International Journal of Health Services Research and Policy %P -2602-3482 %V 2 %N 2 %R doi: 10.23884/ijhsrp.2017.2.2.04 %U 10.23884/ijhsrp.2017.2.2.04
ISNAD Çeli̇k, Menşure Nur , Ünlü Söğüt, Mehtap . "EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS". International Journal of Health Services Research and Policy 2 / 2 (December 2017): 58-64 . https://doi.org/10.23884/ijhsrp.2017.2.2.04
AMA Çeli̇k M , Ünlü Söğüt M . EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS. IJHSRP. 2017; 2(2): 58-64.
Vancouver Çeli̇k M , Ünlü Söğüt M . EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS. International Journal of Health Services Research and Policy. 2017; 2(2): 58-64.