The Role of Colchicine and Potential Medicinal Plants in the Treatment of Familial Mediterranean Fever

Year 2023, Volume: 6 Issue: 1, 119 - 142, 15.04.2023

Tuba Serbetcı , Başak Ceylan

https://doi.org/10.38001/ijlsb.1198033

Abstract

Familial Mediterranean Fever; it is a congenital antiinflammatory disease that effects the immune system, inheriting an autosomal recessive gene. The disease is observed as a result of mutation in the MEFV gene on chromosome 16. It is a disease that progresses with recurrent fever and serositis attacks. The alkaloid named colchicine, obtained from the seeds of the medicinal plant Colchicum autumnale L., is widely used and plays an active role in the treatment of FMF today. Some recent studies provide meaningful data that the combination of herbs Andrographis paniculata Nees., Eleutherococcus senticosus Maxim., Schizandra chinensis Bail., and Glycyrrhiza glabra L. is safe and effective in patients with FMF. Cannabis sativa L. is evaluated as an alternative therapeutic option in mixed FMF cases. In this study, it is aimed to examine in detail colchicine, a natural origin drug substance used in the treatment of FMF, as well as to evaluate other potential medicinal plant species.

Keywords

Familial Mediterranean Fever, FMF treatment, Colchicine, Medicinal plants

Ailevi Akdeniz Ateşi Hastalığı’nın Tedavisinde Kolşisin’in Yeri Ve Potansiyel Tıbbi Bitkiler

Abstract

Ailevi Akdeniz Ateşi; otozomal resesif genin kalıtımıyla, doğuştan gelen ve immün sistemi etkileyen bir antiinflamatuvar hastalıktır. Hastalık, 16. kromozomdaki MEFV geninde oluşan mutasyon sonucu gözlenir. Tekrarlayan ateş ve serözit ataklarla seyreden bir hastalıktır. Colchicum autumnale L. isimli tıbbi bitkinin tohumlarından elde edilen kolşisin isimli alkaloid günümüzde AAA tedavisinde yaygın olarak kullanılmakta ve etkin bir rol oynamaktadır. Yakın zamanlı bazı araştırmalar Andrographis paniculata Nees., Eleutherococcus senticosus Maxim., Schizandra chinensis Bail., and Glycyrrhiza glabra L. bitki kombinasyonun AAA hastalarında güvenli ve etkili olduğuna dair anlamlı veriler sunmaktadır. Cannabis sativa L. ise karışık AAA olgularında alternatif bir terapötik seçenek olarak değerlendirmektedir. Bu çalışmada AAA tedavisinde kullanılan doğal kökenli bir ilaç etkin maddesi olan kolşisinin detaylı incelenmesi ile bunun yanı sıra diğer potansiyel tıbbi bitki türlerinin değerlendirilmesi amaçlanmaktadır.

Keywords

Ailevi Akdeniz Ateşi, AAA tedavisi, Kolşisin, Tıbbi bitkiler.

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