<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article  article-type="research-article"        dtd-version="1.4">
            <front>

                <journal-meta>
                                                                <journal-id>ijmsit</journal-id>
            <journal-title-group>
                                                                                    <journal-title>International Journal of Multidisciplinary Studies and Innovative Technologies</journal-title>
            </journal-title-group>
                            <issn pub-type="ppub">2602-4888</issn>
                                        <issn pub-type="epub">2602-4888</issn>
                                                                                            <publisher>
                    <publisher-name>SET Teknoloji</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id/>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Deep Learning</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Derin Öğrenme</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <article-title>COVID-19 and Non-COVID-19 Classification from Lung CT-Scan Images Using Deep Convolutional Neural Networks</article-title>
                                                                                                                                        </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-3947-898X</contrib-id>
                                                                <name>
                                    <surname>Dolma</surname>
                                    <given-names>Özlü</given-names>
                                </name>
                                                                    <aff>PAMUKKALE ÜNİVERSİTESİ</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20231219">
                    <day>12</day>
                    <month>19</month>
                    <year>2023</year>
                </pub-date>
                                        <volume>7</volume>
                                        <issue>2</issue>
                                        <fpage>53</fpage>
                                        <lpage>60</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20231027">
                        <day>10</day>
                        <month>27</month>
                        <year>2023</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20231205">
                        <day>12</day>
                        <month>05</month>
                        <year>2023</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2017, International Journal of Multidisciplinary Studies and Innovative Technologies</copyright-statement>
                    <copyright-year>2017</copyright-year>
                    <copyright-holder>International Journal of Multidisciplinary Studies and Innovative Technologies</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>In this study, three different convolutional neural network (CNN) architectures have been used for SARS-COV-2 infection (COVID-19) detection from lung Computerized Tomography (CT) scan images. The dataset comprises 2481 lung CT-scan images, of which 1252 are positive for COVID-19 infection. First, a simple CNN, LeNet-5, was trained from scratch, which resulted in poor classification performance with an accuracy value of 0.78. Then, to overcome the drawback of the limited availability of data, the convolutional bases of two pre-trained networks, VGG-16 and MobileNet, were leveraged to extract features from the dataset. On top of the feature extraction outputs, new classifiers were trained. When the VGG16 and the MobileNet CNN’s convolutional bases were used for feature extraction, accuracy values of 0.974 and 0.984 were obtained, respectively. The findings indicate that using pre-trained CNN models for feature extraction and then training a simpler, fully connected network structure for classification successfully differentiates CT-scan images of patients with COVID-19 infection from the ones without COVID-19 infection.</p></abstract>
                                                                                    
            
                                                            <kwd-group>
                                                    <kwd>COVID-19</kwd>
                                                    <kwd>  Convolutional Neural Networks</kwd>
                                                    <kwd>  Feature Extraction</kwd>
                                                    <kwd>  Classification</kwd>
                                                    <kwd>  Deep Learning</kwd>
                                            </kwd-group>
                                                        
                                                                                                                                                    </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">[1]	H. P. Chan, L. M. Hadjiiski, and R. K. Samala, “Computer‐aided diagnosis in the era of deep learning,” Medical Physics, 47(5), pp. e218-e227, 2020.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">[2]	N. Petrick, B. Sahiner, S.G. Armato III, A. Bert, L. Correale, S. Delsanto, M.T. Freedman, D. Fryd, D. Gur, L. Hadjiiski, Z. Huo, Y. Jiang, L. Morra, S. Paquerault, V. Raykar, F. Samuelson, R.M. Summers, G. Tourassi, H. Yoshida, B. Zheng, C. Zhou, and H. P. Chan, “Evaluation of Computer-Aided Detection and Diagnosis Systems,” Medical Physics, 40(8), 2013.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">[3]	K. Chockley and E. Emanuel, “The end of radiology? Three threats to the future practice of radiology,” Journal of the American College of Radiology: JACR, 13(12), pp. 1415-1420, 2016.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">[4]	A. Panthakkan, S. M. Anzar., S. Al-Mansoori, and H. Al-Ahmad, “A novel DeepNet model for the efficient detection of COVID-19 for symptomatic patients,” Biomedical Signal Processing and Control, 68, pp. 1-10, 2021.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">[5]	M.C. Younis, “Evaluation of deep learning approaches for identification of different Corona-Virus species and time series prediction,” Computerized Medical Imaging and Graphics, 90, pp. 1-13, 2021.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">[6]	E. Soares, P. Angelov, S. Biaso, M. H. Froes, and D. K. Abe, “SARS-CoV-2 CT-scan dataset: A large dataset of real patients CT Scans for SARS-CoV-2 identification,” MedRxiv, 2020.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">[7]	Y. LeCun, L. Bottou, Y. Bengio, and P. Haffner, “Gradient-based learning applied to document recognition,” in Proc. IEEE, 1998, 86(11), p. 2278.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">[8]	(2023) Dive into Deep Learning website. [Online]. Available:  https://d2l.ai/chapter_convolutional-neural-networks/lenet.html</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">[9]	G. Hong, X. Chen, J. Chen, M. Zhang, Y. Ren, and X. Zhang, “A multi-scale gated multi-head attention depthwise separable CNN model for recognizing COVID-19,” Scientific Reports, 11(1), pp. 1-13, 2021.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">[10]	E.D. Carvalho, E.D. Carvalho, A.O. de Carvalho Filho, F.H.D. De Araújo, and R.D.A.L. Rabêlo, “Diagnosis of COVID-19 in CT image using CNN and XGBoost,” in Proc. IEEE Symposium on Computers and Communications (ISCC), 2020.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">[11]	M. R. Islam and A. Matin, “Detection of COVID 19 from CT image by the novel LeNet-5 CNN architecture,” in Proc. 23rd International Conference on Computer and Information Technology (ICCIT), 2020.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">[12]	T.	Chen and C. Guestrin, “XGBoost: A scalable tree boosting system,” in Proc. KDD &#039;16: 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, 2016, p. 785.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">[13]	F. Chollet, Deep Learning with Python, 2nd ed., Manning Publications, 2021.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">[14]	K. Simonyan and A. Zisserman, “Very deep convolutional networks for large-scale image recognition,” in Proc. 3rd International Conference on Learning Representations (ICLR), 2015.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">[15]	A. G. Howard, M. Zhu, B. Chen, D. Kalenichenko, W. Wang, T. Weyand, M. Andreetto, and H. Adam, “MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applications,” ArXiv:1704.04861, 2017.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">[16]	O. Russakovsky, J. Deng, H. Su, J. Krause, S. Satheesh, S. Ma, Z. Huang, A. Karpathy, A. Khosla, M. Bernstein, A. C. Berg, and L. Fei-Fei, “ImageNet large scale visual recognition challenge,” International Journal of Computer Vision, 115(3), pp. 211-252, 2015.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">[17]	G. James, D. Witten, T. Hastie, and R. Tibshirani, An Introduction to Statistical Learning with Applications in R, 2nd ed., Springer, 2021.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">[18]	J., Sun, X., Li, C., Tang, S. H., Wang, and Y. D. Zhang, “MFBCNNC: Momentum factor biogeography convolutional neural network for COVID-19 detection via Chest X-ray images,” Knowledge-Based Systems, 232, pp. 1-21, 2021.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">[19]	A. Géron, Hands-On Machine Learning with Scikit-Learn, Keras, and TensorFlow Concepts, Tools, and Techniques to Build Intelligent Systems, 2nd ed., O’Reilly Media, Inc., 2019.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">[20]	G. E. Hinton, N. Srivastava, A. Krizhevsky, I. Sutskever, and R. R. Salakhutdinov, “Improving Neural Networks by Preventing Co-Adaptation of Feature Detectors,” ArXiv:1207.0580, 2012.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">[21]	W. Zhu, W. Yeh, J. Chen, D. Chen, A. Li, and Y. Lin, “Evolutionary convolutional neural networks using ABC,” in Proc. 11th International Conference on Machine Learning and Computing (ICMLC), 2019, p. 156.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">[22]	M.T. Dang, A Survey on Transfer Learning for COVID-19 Medical Imaging Diagnosis. In: Pan, JS., Li, J., Ryu, K.H., Meng, Z., Klasnja-Milicevic, A. (Eds.), Advances in Intelligent Information Hiding and Multimedia Signal Processing. Smart Innovation, Systems and Technologies. Springer, 2021, vol 212.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">[23]	A. Halder and B. Datta, “COVID-19 detection from lung Ct-Scan images using transfer learning approach,” Machine Learning: Science and Technology, 2(4), 2021.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">[24]	K. S. Briskline, D. Murugan, and A. Petchiammal, “COVIDnet: An efficient deep learning model for COVID-19 diagnosis on chest CT images,” International Journal of Advanced Computer Science and Applications, 13(11), pp. 832-839, 2022.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">[25]	R. R. Selvaraju, M. Cogswell, A. Das, R. Vedantam, D.,Parikh, and D. Batra, “Grad-CAM: Visual explanations from deep networks via gradient-based localization,” International Journal of Computer Vision, 128 (2), pp. 336-359, 2019.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">[26]	K. He, G. Gkioxari, P. Dollár, and R. Girshick, “Mask R-CNN,” in Proc. IEEE International Conference on Computer Vision, 2017, pp. 2961.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
