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Comparative toxicity of cinnamon oil, cinnamaldehyde and their nano-emulsions against Culex pipiens (L.) larvae with biochemical and docking studies

Year 2022, Volume: 2 Issue: 1, 51 - 63, 15.06.2022

Abstract

The larvicidal activity of cinnamon oil and its main component, cinnamaldehyde, was compared with their nano-emulsions (NEs) against Culex pipiens mosquito larvae. Oil-in-water (O/W) NEs preparation was based on the coarse emulsion followed by high-energy ultra-sonication. The droplet size, polydispersity index (PDI), viscosity, zeta potential, and pH of NEs were investigated. The droplet sizes of the NEs were 95.67 nm for cinnamon oil and 174.59 nm for cinnamaldehyde. The NEs recorded high negative zeta potentials (-30.0 and -21.20 for cinnamon oil and cinnamaldehyde, respectively). The larvicidal activity results showed that the cinnamaldehyde (LC50 = 94.46 and 72.91 mg/l for T and NE, respectively) had higher activities than cinnamon oil (LC50 = 154.08 and 123.13 mg/l for T and NE, respectively) after 24 h of exposure against C. pipiens larvae. These results proved that NE formulation enhanced the activity of tested compounds against larvae. The in vitro effect on the acetylcholinesterase (AChE), adenosine triphosphatase (ATPase), and gamma-aminobutyric acid transaminase (GABA-T) were demonstrated, and the data proved that the NEs formulations were higher than their pure compounds. Non-formulated cinnamon oil and cinnamaldehyde caused 17.26% and 30.83% of AChE, respectively, while their NEs caused 46.40% and 60.59% inhibition. Furthermore, the molecular docking studies indicated that the affinity binding of cinnamaldehyde on AChE and GABA-T was higher than ATPase. This work describes bio-products with potential use against C. pipiens larvae as eco-friendly products.

References

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Year 2022, Volume: 2 Issue: 1, 51 - 63, 15.06.2022

Abstract

References

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  • Abdelrasoul, M.A., Ahmed, A.R., Badawy, M.E.I., 2018. Formulation, Characterizations and Antibacterial Activity of some Nanoemulsions Incorporating Monoterpenes. Journal of Plant Protection and Pathology, 9(10), 697-705.
  • Abdelrasoul, M.A., Eid, A.R., Badawy, M.E., 2020. Preparation, characterizations and antibacterial activity of different nano-emulsions incorporating monoterpenes: in vitro and in vivo studies. Archives of Phytopathology and Plant Protection, 53(7-8), 310-334.
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  • Dias, C.N., Moraes, D.F.C., 2014. Essential oils and their compounds as Aedes aegypti L.(Diptera: Culicidae) larvicides. Parasitology Research, 113(2), 565-592.
  • Drais, H.K., Hussein, A.A., 2015. Formulation and characterization of carvedilol nano-emulsion oral liquid dosage form. International Journal of Pharmaceutical Science, 7(12), 209-216.
  • El-Sabrout, A.M., Zoghroban, A.A., Abdelgaleil, S.A., 2020. Chemical composition and effects of four essential oils on mortality, development and physiology of the West Nile virus vector, Culex pipiens. International Journal of Tropical Insect Science, 40, 789-799.
  • El Gohary, E.G., Farag, S., El-Sayed, A., Khattab, R., Mahmoud, D., 2021. Insecticidal Activity and Biochemical Study of the Clove Oil (Syzygium aromaticum) Nano-Formulation on Culex pipiens L.(Diptera: Culicidae). Egyptian Journal of Aquatic Biology and Fisheries, 25(1), 227-239.
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  • Faleiro, M.L., 2011. The mode of antibacterial action of essential oils. Science Against Microbial Pathogens: Communicating Current Research and Technological Advances, 2, 1143-1156.
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  • Finney, D.J., 1971. Probit Analysis: 3d Ed. Cambridge University Press.
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  • Ghosh, V., Saranya, S., Mukherjee, A., Chandrasekaran, N., 2013. Cinnamon oil nano-emulsion formulation by ultrasonic emulsification: investigation of its bactericidal activity. Journal of Nanoscience and Nanotechnology, 13(1), 114-122.
  • Gumede, N.J., Singh, P., Sabela, M.I., Bisetty, K., Escuder-Gilabert, L., Medina-Hernández, M.J., Sagrado, S., 2012. Experimental-like affinity constants and enantioselectivity estimates from flexible docking. Journal of Chemical Information and Modeling, 52(10), 2754-2759.
  • Halgren, T.A., 1999. MMFF VI. MMFF94s option for energy minimization studies. Journal of Computational Chemistry, 20(7), 720-729.
  • Holder, P., Browne, G., Bullians, M., 1999. The mosquitoes of New Zealand and their animal disease significance. Surveillance, 26(4), 12-15.
  • IBM 2017. Corp. Released 2017. IBM SPSS Statistics for Windows, Version 25.0. Armonk, NY: IBM Corp.
  • Izquierdo, P., Esquena, J., Tadros, T.F., Dederen, C., Garcia, M.J., Azemar, N., Solans, C., 2002. Formation and stability of nano-emulsions prepared using the phase inversion temperature method. Langmuir, 18(1), 26-30.
  • Jesser, E., Yeguerman, C., Gili, V., Santillan, G., Murray, A.P., Domini, C., Werdin-González, J.O., 2020. Optimization and characterization of essential oil nano-emulsions using ultrasound for new ecofriendly insecticides. ACS Sustainable Chemistry & Engineering, 8(21), 7981-7992.
  • Kabri, T.H., Arab-Tehrany, E., Belhaj, N., Linder, M., 2011. Physico-chemical characterization of nano-emulsions in cosmetic matrix enriched on omega-3. Journal of Nanobiotechnology, 9(1), 1-8.
  • Karuppusamy, B., Sarma, D.K., Lalmalsawma, P., Pautu, L., Karmodiya, K., Nina, P.B., 2021. Effect of climate change and deforestation on vector borne diseases in the North-Eastern Indian state of Mizoram bordering Myanmar. The Journal of Climate Change and Health, 2, 100015.
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There are 79 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Research Articles
Authors

Nehad Taktak This is me 0000-0002-5542-8851

Mohamed Badawy 0000-0002-6923-5452

Osama Awad This is me 0000-0002-7372-5462

Nadia Abou El-ela This is me 0000-0002-7372-5462

Publication Date June 15, 2022
Submission Date December 2, 2021
Published in Issue Year 2022 Volume: 2 Issue: 1

Cite

APA Taktak, N., Badawy, M., Awad, O., Abou El-ela, N. (2022). Comparative toxicity of cinnamon oil, cinnamaldehyde and their nano-emulsions against Culex pipiens (L.) larvae with biochemical and docking studies. International Journal of Plant Based Pharmaceuticals, 2(1), 51-63.
AMA Taktak N, Badawy M, Awad O, Abou El-ela N. Comparative toxicity of cinnamon oil, cinnamaldehyde and their nano-emulsions against Culex pipiens (L.) larvae with biochemical and docking studies. Int. J. Plant Bas. Pharm. June 2022;2(1):51-63.
Chicago Taktak, Nehad, Mohamed Badawy, Osama Awad, and Nadia Abou El-ela. “Comparative Toxicity of Cinnamon Oil, Cinnamaldehyde and Their Nano-Emulsions Against Culex Pipiens (L.) Larvae With Biochemical and Docking Studies”. International Journal of Plant Based Pharmaceuticals 2, no. 1 (June 2022): 51-63.
EndNote Taktak N, Badawy M, Awad O, Abou El-ela N (June 1, 2022) Comparative toxicity of cinnamon oil, cinnamaldehyde and their nano-emulsions against Culex pipiens (L.) larvae with biochemical and docking studies. International Journal of Plant Based Pharmaceuticals 2 1 51–63.
IEEE N. Taktak, M. Badawy, O. Awad, and N. Abou El-ela, “Comparative toxicity of cinnamon oil, cinnamaldehyde and their nano-emulsions against Culex pipiens (L.) larvae with biochemical and docking studies”, Int. J. Plant Bas. Pharm., vol. 2, no. 1, pp. 51–63, 2022.
ISNAD Taktak, Nehad et al. “Comparative Toxicity of Cinnamon Oil, Cinnamaldehyde and Their Nano-Emulsions Against Culex Pipiens (L.) Larvae With Biochemical and Docking Studies”. International Journal of Plant Based Pharmaceuticals 2/1 (June 2022), 51-63.
JAMA Taktak N, Badawy M, Awad O, Abou El-ela N. Comparative toxicity of cinnamon oil, cinnamaldehyde and their nano-emulsions against Culex pipiens (L.) larvae with biochemical and docking studies. Int. J. Plant Bas. Pharm. 2022;2:51–63.
MLA Taktak, Nehad et al. “Comparative Toxicity of Cinnamon Oil, Cinnamaldehyde and Their Nano-Emulsions Against Culex Pipiens (L.) Larvae With Biochemical and Docking Studies”. International Journal of Plant Based Pharmaceuticals, vol. 2, no. 1, 2022, pp. 51-63.
Vancouver Taktak N, Badawy M, Awad O, Abou El-ela N. Comparative toxicity of cinnamon oil, cinnamaldehyde and their nano-emulsions against Culex pipiens (L.) larvae with biochemical and docking studies. Int. J. Plant Bas. Pharm. 2022;2(1):51-63.