The effect of ATP-binding cassette (ABC) transporters in human cancers

Year 2019, Volume: 1 Issue: 1, 14 - 19, 19.08.2019

Seda Mesci , Sevgi Marakli , Burak Yazgan , Tuba Yıldırım

https://doi.org/10.38058/ijsl.594000

Cited By: 2

Abstract

Multi-drug resistance (MDR) can be defined
as a negative effect on the drug-target relationships, decreasing in intracellular
drug aggregation. ABC (ATP-binding cassette) are popular transporter proteins in
the development of MDR. ABC proteins in the cell membrane structure reduce the
therapeutic efficacy and cause drug resistance in cancer patients. Resistance
to chemotherapy is a remarkable and important issue in the treatment of cancer
patients. These drug resistance proteins interfere with the drugs administered
to patients, resulting in a decrease in bioavailability of these drugs and a
reduction in their passage through the blood-brain barrier. ABC transporters
are the largest family of transmembrane proteins with 8 subfamilies assigned
from A to G based on sequence and structural homology. In this review, general
information about ABC proteins is mentioned and the role of ABC proteins causing
MDR in cancers is also discussed. 

Keywords

ABC transporters, Multi-Drug Resistance, Cancer Treatment

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