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Year 2021, Volume: 3 Issue: 2, 109 - 120, 24.08.2021
https://doi.org/10.38058/ijsl.980689

Abstract

References

  • Aledwany, A. Z., Basal, W. T., Al-Senosy, N. K., Issa, A. M. 2018. Assessment of genotoxicity of potassium nitrate and sodium benzoate in Drosophila melanogaster using smart and comet assays, Egyptian Academic Journal of Biological Sciences C, Physiology and Molecular Biology, 10(2): 83-97.
  • Ataseven, N., Yüzbaşıoğlu, D., Keskin, A. Ç., Ünal, F. 2016. Genotoxicity of monosodium glutamate, Food and Chemical Toxicology, 91: 8-18.
  • Ataseven, N., Yüzbaşioğlu, D., Ünal, F. Assessment of Food preservative potassium propionate (e283) genotoxicity in human peripheral blood lymphocytes using micronucleus test. The 3rd International Symposium on EuroAsian Biodiversity, 05-08 July 2017, Minsk- Belarus.
  • Avuloglu-Yilmaz, E., Yuzbasioglu, D., Unal, F. 2020. In vitro genotoxicity assessment of monopotassium glutamate and magnesium diglutamate, Toxicology in Vitro, 65: 104780.
  • Ayaz, A., Yurttagül, M. 2012. Toxic elements in food-II, Ankara Ministry of Health Publications, 727.
  • Ayper, B. O. Ğ. A., & Binokay, S. 2010. Gıda katkı maddeleri ve sağlığımıza etkileri, Arşiv Kaynak Tarama Dergisi, 19(3): 141-154.
  • Azqueta, A., Collins, A. R. 2013. The essential comet assay: a comprehensive guide to measuring DNA damage and repair, Archives of Toxicology, 87(6): 949-968.
  • Bastaki, M., Farrell, T., Bhusari, S., Pant, K., & Kulkarni, R. 2017. Lack of genotoxicity in vivo for food color additive Allura Red AC, Food and Chemical Toxicology, 105: 308-314.
  • Bellani, L., Muccifora, S., Barbieri, F., Tassi, E., Castiglione, M. R. Giorgetti, L. 2020. Genotoxicity of the food additive E171, titanium dioxide, in the plants Lens culinaris L. and Allium cepa L. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 849: 503142.
  • Bogar, F., Tuylu, B. 2019. Determination of genotoxic effects of some food additives with the help of CBMN technique, Fresenius Environmental Bulletin, 28(9): 6601-6611.
  • Chassaing, B., Koren, O., Goodrich, J. K., Poole, A. C., Srinivasan, S., Ley, R. E., Gewirtz, A. T. 2015. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome, Nature, 519(7541): 92-96.
  • Cowan, T. E., Palmnas, M., Reimer, R., Ardell, K., Yang, J. J., Vogel, H., Shearer, J. 2013. Artificial sweetener consumption differentially affects the gut microbiota‐host metabolic interactions, The FASEB Journal, 27: 224.7-224.7.
  • El-Hefny, I., Hozayen, W., Alsenosy, N., Basal, W., Ahmed, A., Diab, A. 2021. Evaluation of genotoxicity of three food preservatıves in Drosophila melanogaster using smart and comet assays, Journal of Microbiology, Biotechnology and Food Sciences, 2021, 38-41.
  • Erkmen, O. 2010. Gıda kaynaklı tehlikeler ve güvenli gıda üretimi, Çocuk Sağlığı ve Hastalıkları Dergisi, 53(3): 220-235.
  • European Food Safety Authority (EFSA), Brancato, A., Brocca, D., Ferreira, L., Greco, L., Jarrah, S. et al. 2018. Use of EFSA pesticide residue intake model (EFSA Primo Revision 3), EFSA Journal, 16(1): E05147.
  • Frâncica, L. S., Gonçalves, E. V., Santos, A. A., Vicente, Y. S., Silva, T. S. et al. 2021. Antiproliferative, genotoxic and mutagenic potential of synthetic chocolate food flavoring, Brazilian Journal of Biology, 82.
  • Güner, U., Muranlı, F. D. G. 2013. Balıklarda tek hücre jel elektroforezi (comet assay), Karadeniz Fen Bilimleri Dergisi, 3(9): 103-114.
  • Haverić, A., Haverić, S., Hadžić, M., Lojo-Kadrić, N., Ibrulj, S. 2018. Genotoxicity and cytotoxicity analysis of curcumin and sunset yellow in human lymphocyte culture, Cellular and Molecular Biology, 64(3): 87-91.
  • Hayashi, M. 2016. The micronucleus test most widely used in vivo genotoxicity test. Genes and Environment, 38(1): 1-6.
  • JECFA Türk Gıda Kodeksi Gıda Katkı Maddeleri Yönetmeliği, Resmî Gazete Tarihi:30.06.2013, Resmî Gazete Sayısı: 28693.
  • Kaya, N. 2020. Cytotoxic and genotoxic effects of triacetin (glycerol triacetate) on Allium cepa root tip, American Journal of Innovative Research and Applied Sciences, 11(1): 1-4.
  • Khan, I. S., Ali, M. N., Hamid, R., Ganie, S. A. 2020. Genotoxic effect of two commonly used food dyes metanil yellow and carmoisine using Allium cepa L. as indicator, Toxicology Reports, 7, 370-375.
  • Mamur, S., Ataseven, N., Fatma, U. Nal, Yüzbaşıoğlu, D. 2018. Determination of genotoxic potential of sodium benzoate and potassium sorbate mixture used as a preservative in foods by micronucleus test. Balıkesir University Journal of Science Institute, 20(2): 235-245.
  • Mohammadzadeh-Aghdash, H., Sohrabi, Y., Mohammadi, A., Shanehbandi, D., Dehghan, P., Dolatabadi, J. E. N. 2018. Safety assessment of sodium acetate, sodium diacetate and potassium sorbate food additives, Food Chemistry, 257: 211-215.
  • Narciso, L., Coppola, L., Lori, G., Andreoli, C., Zjino, A. et al. 2020. Genotoxicity, biodistribution and toxic effects of silver nanoparticles after in vivo acute oral administration, NanoImpact, 18, 100221.
  • Omurtag, G. Z., Aricioglu, F., Sardas, S., Oguz, S. 2013. The investigation of mutagenic and carcinogenic effects by the Ames test, Clinical and Experimental Health Sciences, 3(2): 75.
  • Otabe, A., Ohta, F., Takumi, A., Lynch, B. 2019. Mutagenicity and genotoxicity studies of aspartame, Regulatory Toxicology and Pharmacology, 103: 345-351.
  • Pongsavee, M., Mishra, R. 2021. Potassium sorbate induces oxidative stress and genotoxicity in human lymphocytes, Indian Journal of Forensic Medicine & Toxicology, 15(2).
  • Sezginer, H., Feruzan, D. A. N. E. 2016. Toksik maddelerin genotoksik analiz yöntemleri, Türk Bilimsel Derlemeler Dergisi, 9(1): 50-55.
  • Skypala, I. J., Williams, M., Reeves, L., Meyer, R., Venter, C. 2015. Sensitivity to food additives, vaso-active amines and salicylates: A review of the evidence, Clinical And Translational Allergy, 5(1): 1-11.
  • Stevens, L. J., Kuczek, T., Burgess, J. R., Stochelski, M. A., Arnold, L. E., Galland, L. 2013. Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children, Nutrition Reviews, 71(5): 268-281.
  • Şekeroğlu, Z. A., Şekeroğlu, V., 2011, Genetik toksisite testleri, Tübav Bilim Dergisi, 4(3), 221-229.
  • Tayfur, M. 2014. A’dan Z’ye Gıda Katkı Maddeleri. Detay Yayıncılık. Ankara, Türkiye.
  • Türkoğlu, Ş. 2015. Evaluation of genotoxic effects of five flavour enhancers (glutamates) on the root meristem cells of Allium cepa, Toxicology and Industrial Health, 31(9): 792-801.
  • Uçar, A., Yılmaz, S., Yılmaz, Ş., Kılıç, M. S. 2018. A research on the genotoxicity of stevia in human lymphocytes, Drug and Chemical Toxicology, 41(2): 221-224.
  • Zeiger, E. 2019. The test that changed the world: the ames test and the regulation of chemicals, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 841: 43-48.

Food Additives and Genotoxicity

Year 2021, Volume: 3 Issue: 2, 109 - 120, 24.08.2021
https://doi.org/10.38058/ijsl.980689

Abstract

In today's changing conditions, there has been an increase in the consumption of ready-made food with the change in eating habits. Moreover, parallel to the increase in ready-made food production, there has been an increase in the food additives used. The dose amounts of food additives are determined as a result of experimental analyses. However, some additives show long-term toxic effects on the human body in genotoxicity tests. In this review, definition of substances, purposes of usage, classification, genotoxicity, definitions of tests and publications of genotoxicity studies in food additives were discussed. The search was conducted in peer-reviewed journals using Science-Direct, Web of Science and Google Scholar. In this study, genotoxicity studies conducted with food additives between 2015-2021 were complied. For this purpose, the keywords ‘‘food additive’’, ‘‘genotoxicity’’ were used together and research articles were included in this study.

References

  • Aledwany, A. Z., Basal, W. T., Al-Senosy, N. K., Issa, A. M. 2018. Assessment of genotoxicity of potassium nitrate and sodium benzoate in Drosophila melanogaster using smart and comet assays, Egyptian Academic Journal of Biological Sciences C, Physiology and Molecular Biology, 10(2): 83-97.
  • Ataseven, N., Yüzbaşıoğlu, D., Keskin, A. Ç., Ünal, F. 2016. Genotoxicity of monosodium glutamate, Food and Chemical Toxicology, 91: 8-18.
  • Ataseven, N., Yüzbaşioğlu, D., Ünal, F. Assessment of Food preservative potassium propionate (e283) genotoxicity in human peripheral blood lymphocytes using micronucleus test. The 3rd International Symposium on EuroAsian Biodiversity, 05-08 July 2017, Minsk- Belarus.
  • Avuloglu-Yilmaz, E., Yuzbasioglu, D., Unal, F. 2020. In vitro genotoxicity assessment of monopotassium glutamate and magnesium diglutamate, Toxicology in Vitro, 65: 104780.
  • Ayaz, A., Yurttagül, M. 2012. Toxic elements in food-II, Ankara Ministry of Health Publications, 727.
  • Ayper, B. O. Ğ. A., & Binokay, S. 2010. Gıda katkı maddeleri ve sağlığımıza etkileri, Arşiv Kaynak Tarama Dergisi, 19(3): 141-154.
  • Azqueta, A., Collins, A. R. 2013. The essential comet assay: a comprehensive guide to measuring DNA damage and repair, Archives of Toxicology, 87(6): 949-968.
  • Bastaki, M., Farrell, T., Bhusari, S., Pant, K., & Kulkarni, R. 2017. Lack of genotoxicity in vivo for food color additive Allura Red AC, Food and Chemical Toxicology, 105: 308-314.
  • Bellani, L., Muccifora, S., Barbieri, F., Tassi, E., Castiglione, M. R. Giorgetti, L. 2020. Genotoxicity of the food additive E171, titanium dioxide, in the plants Lens culinaris L. and Allium cepa L. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 849: 503142.
  • Bogar, F., Tuylu, B. 2019. Determination of genotoxic effects of some food additives with the help of CBMN technique, Fresenius Environmental Bulletin, 28(9): 6601-6611.
  • Chassaing, B., Koren, O., Goodrich, J. K., Poole, A. C., Srinivasan, S., Ley, R. E., Gewirtz, A. T. 2015. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome, Nature, 519(7541): 92-96.
  • Cowan, T. E., Palmnas, M., Reimer, R., Ardell, K., Yang, J. J., Vogel, H., Shearer, J. 2013. Artificial sweetener consumption differentially affects the gut microbiota‐host metabolic interactions, The FASEB Journal, 27: 224.7-224.7.
  • El-Hefny, I., Hozayen, W., Alsenosy, N., Basal, W., Ahmed, A., Diab, A. 2021. Evaluation of genotoxicity of three food preservatıves in Drosophila melanogaster using smart and comet assays, Journal of Microbiology, Biotechnology and Food Sciences, 2021, 38-41.
  • Erkmen, O. 2010. Gıda kaynaklı tehlikeler ve güvenli gıda üretimi, Çocuk Sağlığı ve Hastalıkları Dergisi, 53(3): 220-235.
  • European Food Safety Authority (EFSA), Brancato, A., Brocca, D., Ferreira, L., Greco, L., Jarrah, S. et al. 2018. Use of EFSA pesticide residue intake model (EFSA Primo Revision 3), EFSA Journal, 16(1): E05147.
  • Frâncica, L. S., Gonçalves, E. V., Santos, A. A., Vicente, Y. S., Silva, T. S. et al. 2021. Antiproliferative, genotoxic and mutagenic potential of synthetic chocolate food flavoring, Brazilian Journal of Biology, 82.
  • Güner, U., Muranlı, F. D. G. 2013. Balıklarda tek hücre jel elektroforezi (comet assay), Karadeniz Fen Bilimleri Dergisi, 3(9): 103-114.
  • Haverić, A., Haverić, S., Hadžić, M., Lojo-Kadrić, N., Ibrulj, S. 2018. Genotoxicity and cytotoxicity analysis of curcumin and sunset yellow in human lymphocyte culture, Cellular and Molecular Biology, 64(3): 87-91.
  • Hayashi, M. 2016. The micronucleus test most widely used in vivo genotoxicity test. Genes and Environment, 38(1): 1-6.
  • JECFA Türk Gıda Kodeksi Gıda Katkı Maddeleri Yönetmeliği, Resmî Gazete Tarihi:30.06.2013, Resmî Gazete Sayısı: 28693.
  • Kaya, N. 2020. Cytotoxic and genotoxic effects of triacetin (glycerol triacetate) on Allium cepa root tip, American Journal of Innovative Research and Applied Sciences, 11(1): 1-4.
  • Khan, I. S., Ali, M. N., Hamid, R., Ganie, S. A. 2020. Genotoxic effect of two commonly used food dyes metanil yellow and carmoisine using Allium cepa L. as indicator, Toxicology Reports, 7, 370-375.
  • Mamur, S., Ataseven, N., Fatma, U. Nal, Yüzbaşıoğlu, D. 2018. Determination of genotoxic potential of sodium benzoate and potassium sorbate mixture used as a preservative in foods by micronucleus test. Balıkesir University Journal of Science Institute, 20(2): 235-245.
  • Mohammadzadeh-Aghdash, H., Sohrabi, Y., Mohammadi, A., Shanehbandi, D., Dehghan, P., Dolatabadi, J. E. N. 2018. Safety assessment of sodium acetate, sodium diacetate and potassium sorbate food additives, Food Chemistry, 257: 211-215.
  • Narciso, L., Coppola, L., Lori, G., Andreoli, C., Zjino, A. et al. 2020. Genotoxicity, biodistribution and toxic effects of silver nanoparticles after in vivo acute oral administration, NanoImpact, 18, 100221.
  • Omurtag, G. Z., Aricioglu, F., Sardas, S., Oguz, S. 2013. The investigation of mutagenic and carcinogenic effects by the Ames test, Clinical and Experimental Health Sciences, 3(2): 75.
  • Otabe, A., Ohta, F., Takumi, A., Lynch, B. 2019. Mutagenicity and genotoxicity studies of aspartame, Regulatory Toxicology and Pharmacology, 103: 345-351.
  • Pongsavee, M., Mishra, R. 2021. Potassium sorbate induces oxidative stress and genotoxicity in human lymphocytes, Indian Journal of Forensic Medicine & Toxicology, 15(2).
  • Sezginer, H., Feruzan, D. A. N. E. 2016. Toksik maddelerin genotoksik analiz yöntemleri, Türk Bilimsel Derlemeler Dergisi, 9(1): 50-55.
  • Skypala, I. J., Williams, M., Reeves, L., Meyer, R., Venter, C. 2015. Sensitivity to food additives, vaso-active amines and salicylates: A review of the evidence, Clinical And Translational Allergy, 5(1): 1-11.
  • Stevens, L. J., Kuczek, T., Burgess, J. R., Stochelski, M. A., Arnold, L. E., Galland, L. 2013. Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children, Nutrition Reviews, 71(5): 268-281.
  • Şekeroğlu, Z. A., Şekeroğlu, V., 2011, Genetik toksisite testleri, Tübav Bilim Dergisi, 4(3), 221-229.
  • Tayfur, M. 2014. A’dan Z’ye Gıda Katkı Maddeleri. Detay Yayıncılık. Ankara, Türkiye.
  • Türkoğlu, Ş. 2015. Evaluation of genotoxic effects of five flavour enhancers (glutamates) on the root meristem cells of Allium cepa, Toxicology and Industrial Health, 31(9): 792-801.
  • Uçar, A., Yılmaz, S., Yılmaz, Ş., Kılıç, M. S. 2018. A research on the genotoxicity of stevia in human lymphocytes, Drug and Chemical Toxicology, 41(2): 221-224.
  • Zeiger, E. 2019. The test that changed the world: the ames test and the regulation of chemicals, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 841: 43-48.

Details

Primary Language English
Journal Section Review
Authors

Pınar ALTUNKAYNAK
AMASYA UNIVERSITY
0000-0002-8539-7726
Türkiye


Ece AVULOĞLU YILMAZ
Amasya Üniversitesi
0000-0002-5164-3431
Türkiye

Publication Date August 24, 2021
Published in Issue Year 2021 Volume: 3 Issue: 2

Cite

APA
ALTUNKAYNAK, P., & AVULOĞLU YILMAZ, E. (2021). Food Additives and Genotoxicity. International Journal of Science Letters, 3(2), 109-120. https://doi.org/10.38058/ijsl.980689
MLA
ALTUNKAYNAK, Pınar and Ece AVULOĞLU YILMAZ. “Food Additives and Genotoxicity”. International Journal of Science Letters, vol. 3, no. 2, 2021, pp. 109-20, doi:10.38058/ijsl.980689.
Chicago
ALTUNKAYNAK, Pınar, and Ece AVULOĞLU YILMAZ. “Food Additives and Genotoxicity”. International Journal of Science Letters 3, no. 2 (August 2021): 109-20. https://doi.org/10.38058/ijsl.980689.
EndNote
ALTUNKAYNAK P, AVULOĞLU YILMAZ E (August 1, 2021) Food Additives and Genotoxicity. International Journal of Science Letters 3 2 109–120.
ISNAD
ALTUNKAYNAK, Pınar - AVULOĞLU YILMAZ, Ece. “Food Additives and Genotoxicity”. International Journal of Science Letters 3/2 (August 2021), 109-120. https://doi.org/10.38058/ijsl.980689.
AMA
ALTUNKAYNAK P, AVULOĞLU YILMAZ E. Food Additives and Genotoxicity. IJSL. August 2021;3(2):109-120. doi:10.38058/ijsl.980689
Vancouver
ALTUNKAYNAK P, AVULOĞLU YILMAZ E. Food Additives and Genotoxicity. IJSL. 2021;3(2):109-20.
IEEE
P. ALTUNKAYNAK and E. AVULOĞLU YILMAZ, “Food Additives and Genotoxicity”, IJSL, vol. 3, no. 2, pp. 109–120, 2021, doi: 10.38058/ijsl.980689.
JAMA
ALTUNKAYNAK P, AVULOĞLU YILMAZ E. Food Additives and Genotoxicity. IJSL. 2021;3:109–120.