int. j. sec. metabolite

International Journal of Secondary Metabolite

2148-6905

İzzet KARA

10.21448/ijsm.377767

Structural Biology

Yapısal Biyoloji

Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro

Erenler

Ramazan

Demirtas

İbrahim

Karan

Tunay

Altun

Muhammed

Gul

Fatih

12 20 2017

4 3, Special Issue 2 512 516 05 04 2017 10 11 2017

2014

International Journal of Secondary Metabolite

Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.

Naturalproducts derived from plants play a significant role in drug discovery due tothe revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts ofthe plant were boiled in water for 2 h then extracted with ethyl acetate. Afterevaporation of the solvent by rotary evaporator, the extract was subjected tocolumn chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone byspectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferativeactivity of isolated compound was tested against HeLa (human cervix carcinoma)cell lines by xCELLigence assay, and found out that the compound exhibitedexcellent activity.

Kickxia spuria flavone HeLa

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