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Protective Effects of Selenopyran Against Carbon Tetrachloride Hepatotoxicity in Rats

Year 2014, Volume: 1 Issue: 1, 26 - 0, 14.07.2014

Abstract

Carbon tetrachloride (CCl4) is a known hepatotoxic compound working through the generation of reactive free radicals. Selenium (Se) is an essential trace element required by animals and humans for protection against xenobiotic compounds. In this study, Se, as selenopyran, has been evaluated for its protective action against CCl4-induced hepatotoxicity in Wistar rats. CCl4 exerts its toxic effects by generation of free radicals; it was intraperitoneally administered to male Wistar rats (2g/kg body weight) 24 h before the animals were decapitated. Selenopyran (2mg/kg body weight) was administered intragastrically one month before CCl4 injection. Rats injected with CCl4 alone showed significant lipid and hydropic dystrophy of liver, massive necrosis of hepatocytes, increases in free and conjugated bilirubin levels were marked as well as elevation of hepatic enzymes (alanine aminotransferase and aspartate aminotransferase) in plasma. Selenopyran administered at a pharmacological dose diminished the toxic effects of CCl4. Thus it decreased both the structural and functional injury of hepatocytes and clearly exerted hepatoprotective effects. These findings suggest that the effect of selenopyran on CCl4-induced acute liver injury depends on the antioxidant action Se.

Year 2014, Volume: 1 Issue: 1, 26 - 0, 14.07.2014

Abstract

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Details

Other ID JA37TP58GD
Journal Section Articles
Authors

L. B. Zavodnık This is me

D. B. Voloshın This is me

A. Skomoroshko This is me

T. N. Budko1 This is me

V. İ. Kondakov This is me

R. N. Lıakh1 This is me

A. M. Khokha This is me

B. Palecz This is me

Publication Date July 14, 2014
Submission Date July 14, 2016
Published in Issue Year 2014 Volume: 1 Issue: 1

Cite

APA Zavodnık, L. B., Voloshın, D. B., Skomoroshko, A., Budko1, T. N., et al. (2014). Protective Effects of Selenopyran Against Carbon Tetrachloride Hepatotoxicity in Rats. International Journal of Secondary Metabolite, 1(1), 26. https://doi.org/10.21448/ijsm.240713
International Journal of Secondary Metabolite

e-ISSN: 2148-6905