Investigation of Some Corticosteroids as Glutathione Reductase Inhibitor

Year 2020, Volume: 7 Issue: 2, 119 - 125, 13.06.2020

Esra Şentürk , Murat Şentürk

https://doi.org/10.21448/ijsm.693816

Cited By: 3

Abstract

The detection of glutathione reductase inhibitors (GRIs) has recently become very popular due to their use as malarial and cancer drugs. Today, steroidal compounds have several clinical roles due to their potent immunomodulating and anti-inflammatory properties. In this study, GR inhibitory capacity of some corticosteroids (dexamethasone, prednisolone and methylprednisolone) has been reported. Amongst these steroidal molecules dexamethasone showed the weakest inhibitory effect on GR enzyme. IC50 values were determined by drawing % activity-[I] graphs for these corticosteroids showing inhibition effects. These corticosteroids have inhibition ranging micromolar for GR with IC50 values. These corticosteroids exhibit very potent inhibitory activity against GR enzyme at low micromolar concentrations when compared to well-known GRIs.

Keywords

Steroid, Glutathione reductase, Inhibition, Oxidative stress, Cancer

Supporting Institution

Ağrı İbrahim Çeçen University Research Council

Project Number

ECZF.19.001

Thanks

This work study was presented as a summary in the 3rd International Conference on Advances in Natural and Applied Sciences (ICANAS 2018), 2018, Antalya, Turkey. Authors gratefully thanks to Swissdock for in silico data.

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