Comparison of The Antimicrobial Activity of Some Scutellaria orientalis L. Taxa Growing in Turkey
Year 2020,
Volume: 7 Issue: 3, 192 - 199, 15.09.2020
Gülderen Yılmaz
,
Duygu Şimşek
,
Nurten Altanlar
,
Mehmet Çiçek
Abstract
Scutellaria species are commonly used in the treatment of various diseases in traditional medicine. One of the members of Lamiaceae, the genus Scutellaria L. has approximately 471 species on earth. The genus is represented by 39 taxa in Turkey which 17 of them are endemics. In this study, plant samples of 15 S. orientalis subspecies from different regions of our country were collected and methanol extracts were prepared from aerial parts. In vitro antimicrobial activity of these extracts against three gram positive and three gram negative bacteria and against a yeast using broth microdilution method. Methanol extracts of S. orientalis taxa were found to have moderate to low antimicrobial activity compared to the literature.
References
- WCSP. (2019). World Checklist of Selected Plant Families. Facilitated by the Royal Botanic Gardens, Kew. Accessed March 1, 2017 at http://apps.kew.org/wcsp/. The Plant List (2013). Version 1.1. Available online: http://www.theplantlist.org/ (accessed on 29 October 2019).
- Paton, A. (1990). The phytogeography of Scutellaria L. Notes from the Royal Botanic Garden, Edinburgh, 46(3), 345-359
- Edmondson, J.R. (1982). Scutellaria L. In: Flora of Turkey and the East Aegean Islands, Vol. 7, P.H. Davis Edit. Edinburgh University Press, Edinburgh. pp. 78–100. ISBN 978-085-2243-96-1.
- Davis, P.H., Mill, R.R., Tan, K. (1988). (Edits.), Flora of Turkey and the East Aegean Islands, Vol. 10. Edinburgh University Press, Edinburgh, pp. 202.
- Duman, H., Güner, A., Özhatay, N., Ekim, T., Baser, K.H.C. (2000). Scutellaria L. In: Flora of Turkey and the East Aegean Islands, Vol. 11. Edinburgh University Press, Edinburgh. pp. 198-199.
- Çiçek, M., Ketenoğlu, O. (2011). Scutellaria anatolica (Lamiaceae), a new species from Turkey. Annales Botanici Fennici, 48(3), 276–279. https://doi.org/10.5735/085.048.0309
- Çiçek, M. (2012). Scutellaria. In: Türkiye Bitkileri Listesi (Damarlı Bitkiler) Güner A, Aslan S, Ekim T, Vural M, and MT Babaç Edits. Nezahat Gökyiğit Botanik Bahçesi ve Flora Araştırmaları Derneği Yayını, İstanbul. pp. 582-585.
- Çiçek, M., Yaprak, A.E. (2011). A new natural hybrid of Scutellaria (Lamiaceae) from Turkey. Phytotaxa, 29, 51–55. https://doi.org/10.11646/phytotaxa.29.1.5
- Çiçek, M., Yaprak, A.E. (2013). Scutellaria yildirimlii (Lamiaceae), a new species from Turkey. Phytotaxa, 132(1), 53–58. https://doi.org/10.11646/phytotaxa.132.1
- Shang, X., He, X., He, X, Li M, Zhang, R., Fan, P., Zhang, Q., Jia, Z. (2010). The genus Scutellaria an ethnopharmacological and phytochemical review. J Ethnopharmacol. 128(2), 279-313. https://doi.org/10.1016/j.jep.2010.01.006
- Arıtuluk, Z.C., Özkul Koçak, C., Renda, G., Ekizoğlu, M., Ezer, N. (2019). Antimicrobial activity of three Scutellaria L. species from Turkey. J. Res. Pharm. 23(3), 552-558. https://doi.org/10.12991/jrp.2019.162
- Baytop, T. (1999). Therapy with medicinal plants in Turkey (past and present) (2nd ed.). Nobel Tıp Kitabevleri, Istanbul; ISBN 975-420-0211.
- Özçelik, H., Ay, G., Öztürk, M. (1990). Some traditional plants of East and Southeast Anatolia. Proceedings of the 10th National Symposium on Biology, Atatürk University, Erzurum, pp. 1-10.
- Altundag, E., Ozturk, M. (2011). Ethnomedicinal studies on the plant resources of east Anatolia, Turkey. Procedia Soc Behav. Sci., 19, 756-777.
https://doi.org/10.1016/j.sbspro.2011.05.195
- Çakilcioglu U, Turkoglu I. (2010). An ethnobotanical survey of medicinal plants in Sivrice (Elazığ-Turkey). J. Ethnopharmacol. 132(1), 165-175. https://doi.org/10.1016/j.jep.2010.08.017
- Ersöz, T., Harput, Ü.Ş., Saracoğlu, İ., Çalış, İ., Ogihara, Y. (2002). Phenolic compounds from Scutellaria pontica. Turk J. Chem., 26(4), 581-588.
- Tuzlacı. E. (2016). Türkiye Bitkileri Geleneksel İlaç Rehberi, İstanbul Tıp Kitabevi, İstanbul. ISBN 978-605-4949-71-7.
- Mükemre, M., Behçet, L., Çakılcıoğlu, U. (2015). Ethnobotanical study on medicinal plants in villages of Çatak (Van-Turkey). J. Ethnopharmacol., 166, 361-374. https://doi.org/10.1016/j.jep.2015.03.040
- Rodríguez, B., de la Torre, M.C., Jimeno, M.L., Bruno, M., Vassallo, N., Bondì, M., Piozzi, F., Servettaz, O. (1997). Neoclerodane diterpenoids from Scutellaria pontica. J. Nat. Prod., 60(4), 348-355. https://doi.org/10.1021/np960714g
- Çiçek, M., Demirci, B., Yılmaz, G., Ketenoğlu, O., Başer, K.H.C. (2010). Composition of the essential oils of subspecies of Scutellaria albida L. from Turkey. Journal of Essential Oil Research, 22(1), 55-58. https://doi.org/10.1080/10412905.2010.9700265
- Çiçek, M., Demirci, B., Yılmaz G., Başer, K.H.C., (2011). Essential oil composition of three species of Scutellaria from Turkey. Natural Product Research, 25(18), 1720-1726. https://doi.org/10.1080/14786419.2010.512997
- Yılmaz, G.., Çiçek, M., Demirci, B., Başer, K.H C. (2019). Essential oil compositions of subspecies of Scutellaria brevibracteata Stapf. from Turkey, Journal of Essential Oil Research (JEOR), 31(4),255-262. https://doi.org/10.1080/10412905.2019.1579762
- Yılmaz, G., Çiçek, M., Demirci, B., Başer, K.H.C., (2019). Composition of the Essential Oils of Scutellaria galericulata and S. tortumensis from Turkey, Natural Volatiles & Essential Oils (NVEO), 6(3), 1-7.
- Saracoglu, I., Inoue, M., Calıs, I., Ogihara, Y. (1995). Studies on constituents with cytotoxic and cytostatic activity of two Turkish medicinal plants Phlomis armeniaca and Scutellaria salviifolia. Biol Pharm Bull. 18(10), 1396-1400. https://doi.org/10.1248/bpb.18.1396
- Şenol, F.S., Orhan, İ., Yılmaz, G., Çiçek, M., Şener, B. (2010). Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey. Food and Chemical Toxicology, 48(3), 781-788. https://doi.org/10.1016/j.fct.2009.12.004
- İçen, M.S., Arabacı, T., Kostekci, S., Gurhan, I. (2016). Chemical composition of the essential oil of Scutellaria orientalis L. subsp. virens (Boiss. &Kotschy) JR Edm. from Turkey. Hacettepe Journal of Biology and Chemistry, 44(1), 25-28. doi: 10.15671/HJBC.20164417563
- Yavuz, C., Dereli Kılıç, D.D., Ayar, A., Yıldırım, T. (2017). Antibacterial effects of methanol of some plant species belonging to Lamiaceae family. Int J Sec Metabolite, 4(3), 429-433. https://doi.org/10.21448/ijsm.376691
- Zengin, G., Llorent‐Martínez, E.J., Molina‐García, L., Fernández‐de Córdova, M.L., Aktumsek, A., Uysal, S., Rengasamyc, K.R.R., Aumeeruddyd, M.Z., Bahadorie, M.B., Mahomoodally, M.F. (2019). Chemical profile, antioxidant, and enzyme inhibitory properties of two Scutellaria species: S. orientalis L. and S. salviifolia Benth. Journal of Pharmacy and Pharmacology, 71(2), 270-280. https://doi.org/10.1111/jphp.13030
- Bardakci, H., Turkoz Acar, E., Kırmızıbekmez, H. (2019). Simultaneous quantification of six flavonoids in four Scutellaria taxa by HPLC-DAD method. Brasilian Journal of Pharmacognosy, 29, 17–23. https://doi.org/10.1016/j.bjp.2018.09.006
- Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. (2012). Approved Standard-Ninth Edition. CLSI document M07-A9 (ISBN 1-56238-783-9 [Print]; ISBN 1-56238-784-7 [Electronic]). Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA.
- NCCLS. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. (2002). Approved Standard-Second Edition. NCCLS document M27-A2 [ISBN 1-56238-469-4]. NCCLS, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA.
- Morales, G, Paredes, A, Sierra, P, Loyola, LA, (2008). Antimicrobial Activity of Three Baccharis Species Used in the Traditional Medicine of Northern Chile. Molecules, 13, 790-794. https://doi.org/10.3390/molecules13040790
- Dereboylu, A.E., Sarikahya, N.B., Sengonca, N., Kirmizigul, S., Yasa, I., Gucel, S., Guvensen, A. (2012). Glandular Trichomes Morphology, Chemical Composition and Antimicrobial Activity of the Essential Oil of Three Endemic Scutellaria Taxa (Lamiaceae). Asian Journal of Chemistry, 24(11), 4911-4916.
Comparison of The Antimicrobial Activity of Some Scutellaria orientalis L. Taxa Growing in Turkey
Year 2020,
Volume: 7 Issue: 3, 192 - 199, 15.09.2020
Gülderen Yılmaz
,
Duygu Şimşek
,
Nurten Altanlar
,
Mehmet Çiçek
Abstract
Scutellaria species are commonly used in the treatment of various diseases in traditional medicine. One of the members of Lamiaceae, the genus Scutellaria L. has approximately 471 species on earth. The genus is represented by 39 taxa in Turkey which 17 of them are endemics. In this study, plant samples of 15 S. orientalis subspecies from different regions of our country were collected and methanol extracts were prepared from aerial parts. In vitro antimicrobial activity of these extracts against three gram positive and three gram negative bacteria and against a yeast using broth microdilution method. Methanol extracts of S. orientalis taxa were found to have moderate to low antimicrobial activity compared to the literature.
References
- WCSP. (2019). World Checklist of Selected Plant Families. Facilitated by the Royal Botanic Gardens, Kew. Accessed March 1, 2017 at http://apps.kew.org/wcsp/. The Plant List (2013). Version 1.1. Available online: http://www.theplantlist.org/ (accessed on 29 October 2019).
- Paton, A. (1990). The phytogeography of Scutellaria L. Notes from the Royal Botanic Garden, Edinburgh, 46(3), 345-359
- Edmondson, J.R. (1982). Scutellaria L. In: Flora of Turkey and the East Aegean Islands, Vol. 7, P.H. Davis Edit. Edinburgh University Press, Edinburgh. pp. 78–100. ISBN 978-085-2243-96-1.
- Davis, P.H., Mill, R.R., Tan, K. (1988). (Edits.), Flora of Turkey and the East Aegean Islands, Vol. 10. Edinburgh University Press, Edinburgh, pp. 202.
- Duman, H., Güner, A., Özhatay, N., Ekim, T., Baser, K.H.C. (2000). Scutellaria L. In: Flora of Turkey and the East Aegean Islands, Vol. 11. Edinburgh University Press, Edinburgh. pp. 198-199.
- Çiçek, M., Ketenoğlu, O. (2011). Scutellaria anatolica (Lamiaceae), a new species from Turkey. Annales Botanici Fennici, 48(3), 276–279. https://doi.org/10.5735/085.048.0309
- Çiçek, M. (2012). Scutellaria. In: Türkiye Bitkileri Listesi (Damarlı Bitkiler) Güner A, Aslan S, Ekim T, Vural M, and MT Babaç Edits. Nezahat Gökyiğit Botanik Bahçesi ve Flora Araştırmaları Derneği Yayını, İstanbul. pp. 582-585.
- Çiçek, M., Yaprak, A.E. (2011). A new natural hybrid of Scutellaria (Lamiaceae) from Turkey. Phytotaxa, 29, 51–55. https://doi.org/10.11646/phytotaxa.29.1.5
- Çiçek, M., Yaprak, A.E. (2013). Scutellaria yildirimlii (Lamiaceae), a new species from Turkey. Phytotaxa, 132(1), 53–58. https://doi.org/10.11646/phytotaxa.132.1
- Shang, X., He, X., He, X, Li M, Zhang, R., Fan, P., Zhang, Q., Jia, Z. (2010). The genus Scutellaria an ethnopharmacological and phytochemical review. J Ethnopharmacol. 128(2), 279-313. https://doi.org/10.1016/j.jep.2010.01.006
- Arıtuluk, Z.C., Özkul Koçak, C., Renda, G., Ekizoğlu, M., Ezer, N. (2019). Antimicrobial activity of three Scutellaria L. species from Turkey. J. Res. Pharm. 23(3), 552-558. https://doi.org/10.12991/jrp.2019.162
- Baytop, T. (1999). Therapy with medicinal plants in Turkey (past and present) (2nd ed.). Nobel Tıp Kitabevleri, Istanbul; ISBN 975-420-0211.
- Özçelik, H., Ay, G., Öztürk, M. (1990). Some traditional plants of East and Southeast Anatolia. Proceedings of the 10th National Symposium on Biology, Atatürk University, Erzurum, pp. 1-10.
- Altundag, E., Ozturk, M. (2011). Ethnomedicinal studies on the plant resources of east Anatolia, Turkey. Procedia Soc Behav. Sci., 19, 756-777.
https://doi.org/10.1016/j.sbspro.2011.05.195
- Çakilcioglu U, Turkoglu I. (2010). An ethnobotanical survey of medicinal plants in Sivrice (Elazığ-Turkey). J. Ethnopharmacol. 132(1), 165-175. https://doi.org/10.1016/j.jep.2010.08.017
- Ersöz, T., Harput, Ü.Ş., Saracoğlu, İ., Çalış, İ., Ogihara, Y. (2002). Phenolic compounds from Scutellaria pontica. Turk J. Chem., 26(4), 581-588.
- Tuzlacı. E. (2016). Türkiye Bitkileri Geleneksel İlaç Rehberi, İstanbul Tıp Kitabevi, İstanbul. ISBN 978-605-4949-71-7.
- Mükemre, M., Behçet, L., Çakılcıoğlu, U. (2015). Ethnobotanical study on medicinal plants in villages of Çatak (Van-Turkey). J. Ethnopharmacol., 166, 361-374. https://doi.org/10.1016/j.jep.2015.03.040
- Rodríguez, B., de la Torre, M.C., Jimeno, M.L., Bruno, M., Vassallo, N., Bondì, M., Piozzi, F., Servettaz, O. (1997). Neoclerodane diterpenoids from Scutellaria pontica. J. Nat. Prod., 60(4), 348-355. https://doi.org/10.1021/np960714g
- Çiçek, M., Demirci, B., Yılmaz, G., Ketenoğlu, O., Başer, K.H.C. (2010). Composition of the essential oils of subspecies of Scutellaria albida L. from Turkey. Journal of Essential Oil Research, 22(1), 55-58. https://doi.org/10.1080/10412905.2010.9700265
- Çiçek, M., Demirci, B., Yılmaz G., Başer, K.H.C., (2011). Essential oil composition of three species of Scutellaria from Turkey. Natural Product Research, 25(18), 1720-1726. https://doi.org/10.1080/14786419.2010.512997
- Yılmaz, G.., Çiçek, M., Demirci, B., Başer, K.H C. (2019). Essential oil compositions of subspecies of Scutellaria brevibracteata Stapf. from Turkey, Journal of Essential Oil Research (JEOR), 31(4),255-262. https://doi.org/10.1080/10412905.2019.1579762
- Yılmaz, G., Çiçek, M., Demirci, B., Başer, K.H.C., (2019). Composition of the Essential Oils of Scutellaria galericulata and S. tortumensis from Turkey, Natural Volatiles & Essential Oils (NVEO), 6(3), 1-7.
- Saracoglu, I., Inoue, M., Calıs, I., Ogihara, Y. (1995). Studies on constituents with cytotoxic and cytostatic activity of two Turkish medicinal plants Phlomis armeniaca and Scutellaria salviifolia. Biol Pharm Bull. 18(10), 1396-1400. https://doi.org/10.1248/bpb.18.1396
- Şenol, F.S., Orhan, İ., Yılmaz, G., Çiçek, M., Şener, B. (2010). Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey. Food and Chemical Toxicology, 48(3), 781-788. https://doi.org/10.1016/j.fct.2009.12.004
- İçen, M.S., Arabacı, T., Kostekci, S., Gurhan, I. (2016). Chemical composition of the essential oil of Scutellaria orientalis L. subsp. virens (Boiss. &Kotschy) JR Edm. from Turkey. Hacettepe Journal of Biology and Chemistry, 44(1), 25-28. doi: 10.15671/HJBC.20164417563
- Yavuz, C., Dereli Kılıç, D.D., Ayar, A., Yıldırım, T. (2017). Antibacterial effects of methanol of some plant species belonging to Lamiaceae family. Int J Sec Metabolite, 4(3), 429-433. https://doi.org/10.21448/ijsm.376691
- Zengin, G., Llorent‐Martínez, E.J., Molina‐García, L., Fernández‐de Córdova, M.L., Aktumsek, A., Uysal, S., Rengasamyc, K.R.R., Aumeeruddyd, M.Z., Bahadorie, M.B., Mahomoodally, M.F. (2019). Chemical profile, antioxidant, and enzyme inhibitory properties of two Scutellaria species: S. orientalis L. and S. salviifolia Benth. Journal of Pharmacy and Pharmacology, 71(2), 270-280. https://doi.org/10.1111/jphp.13030
- Bardakci, H., Turkoz Acar, E., Kırmızıbekmez, H. (2019). Simultaneous quantification of six flavonoids in four Scutellaria taxa by HPLC-DAD method. Brasilian Journal of Pharmacognosy, 29, 17–23. https://doi.org/10.1016/j.bjp.2018.09.006
- Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. (2012). Approved Standard-Ninth Edition. CLSI document M07-A9 (ISBN 1-56238-783-9 [Print]; ISBN 1-56238-784-7 [Electronic]). Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA.
- NCCLS. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. (2002). Approved Standard-Second Edition. NCCLS document M27-A2 [ISBN 1-56238-469-4]. NCCLS, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA.
- Morales, G, Paredes, A, Sierra, P, Loyola, LA, (2008). Antimicrobial Activity of Three Baccharis Species Used in the Traditional Medicine of Northern Chile. Molecules, 13, 790-794. https://doi.org/10.3390/molecules13040790
- Dereboylu, A.E., Sarikahya, N.B., Sengonca, N., Kirmizigul, S., Yasa, I., Gucel, S., Guvensen, A. (2012). Glandular Trichomes Morphology, Chemical Composition and Antimicrobial Activity of the Essential Oil of Three Endemic Scutellaria Taxa (Lamiaceae). Asian Journal of Chemistry, 24(11), 4911-4916.