Kistik Fibrozisli Hastalarda COVID-19’un Etkisi ve Tıbbi Beslenme Tedavisi

Year 2023, Volume: 8 Issue: 1, 177 - 182, 31.01.2023

Melike Yıldız , Büşra Canarslan Büşra Aslan Gönül

Abstract

Kistik fibrozis, epitel hücresi membranındaki Kistik Fibrozis Transmembran Regülator adlı klor kanalında meydana gelen mutasyon sonucu dış salgı bezlerindeki fonksiyon bozukluğudur. Kistik Fibrozis Transmembran Regülatordeki yapısal ve fonksiyonel bozukluk; solunum yolları, pankreas, safra kanalları, üreme organları ve gastrointestinal sistem gibi organların epitel hücre membranlarında klor transportunun bozulmasına neden olur. Kistik fibrozisli hastalarda görülen akciğer enfeksiyonu morbidite ve mortalite prevalansını arttırmaktadır. Kistik fibrozis; hava yollarında oluşan kalınlaşmış sekresyonlar, enfeksiyon artışı ve kalıcılığı için olumsuz bir ortam yaratmaktadır. Viral enfeksiyonlar, kistik fibrozisin seyrinde önemli bir rol oynadığı için, kistik fibrozisli hastalarının şiddetli akut solunum sendromu koronavirüs-2 enfeksiyonu durumunda ciddi belirtiler geliştirme riskinin yüksek olduğu düşünülmektedir. Ancak kistik fibrozisli hastalar arasında koruyucu maske takılması, insanlarla temasın az olması veya konakçı faktörlerden kaçınma gibi davranışlar sayesinde akut solunum sendromu koronavirüs-2 insidansının (%0,07) genel popülasyonlardaki ortalama insidansın (%0,15) altında olduğu görülmüştür. Kistik fibrozisli hastalar ve aileleri, hastalığın yönetilmesinde genel popülasyona kıyasla birçok zorlukla karşı karşıyadır. Özellikle pandemi döneminde ilaç tedavisi, fizyoterapi, egzersiz ve tıbbi beslenme tedavisi gibi yöntemlerle yönetilen kistik fibrozis tedavi sürecinde kişiselleştirilmiş beslenme tedavisi uygulayarak bireylerin sağlığını olumlu yönde etkilemek oldukça önemlidir. Pandemi dönemi; besine ulaşımdaki zorluk, sosyal izolasyon ve gıda güvensizliği gibi nedenler ile kistik fibrozisli hastaların beslenme alışkanlıklarında değişikliklere neden olmuş olabilir. Bu derleme makalenin amacı kistik fibrozisli hastalarda COVID-19’un etkisini incelemek ve pandemi dönemindeki tıbbi beslenme tedavisini değerlendirmektir.

Keywords

COVID-19, kistik fibrozis, beslenme tedavisi.

Effect of COVID-19 and Medical Nutrition Therapy in Patients with Cystic Fibrosis

Abstract

Cystic fibrosis is a dysfunction in the exocrine glands as a result of mutation in the chloride channel called Cystic Fibrosis Transmembrane Regulator in the epithelial cell membrane. Structural and functional disorder in Cystic Fibrosis Transmembrane Regulator; it causes disruption of chloride transport in epithelial cell membranes of organs such as respiratory tract, pancreas, bile ducts, reproductive organs and gastrointestinal tract. Lung infection seen in patients with cystic fibrosis increases the prevalence of morbidity and mortality. Cystic fibrosis; The thickened secretions formed in the airways create a negative environment for the increase and persistence of infection. Because viral infections play an important role in the course of cystic fibrosis, patients with cystic fibrosis are thought to be at high risk of developing severe symptoms in the case of severe acute respiratory syndrome coronavirus-2 infection. However, among patients with cystic fibrosis, the incidence of acute respiratory syndrome coronavirus-2 (0.07%) was found to be below the average incidence (0.15%) in general populations, thanks to behaviors such as wearing a protective mask, little contact with people, or avoiding host factors. Patients with cystic fibrosis and their families face many challenges in managing the disease compared to the general population. It is very important to positively affect the health of individuals by applying personalized nutrition therapy in the treatment process of cystic fibrosis, which is managed by methods such as drug therapy, physiotherapy, exercise and medical nutrition therapy, especially during the pandemic period. Pandemic period; Difficulty in accessing food, social isolation and food insecurity may have caused changes in the nutritional habits of patients with cystic fibrosis. The aim of this review article is to examine the effect of COVID-19 in patients with cystic fibrosis and to evaluate medical nutrition therapy during the pandemic period.

Keywords

COVID-19, cystic fibrosis, nutrition therapy.

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