interdiscip med j Interdisciplinary Medical Journal 2980-1915 Hatay Mustafa Kemal University 10.17944/interdiscip.1819793 Obstetrics and Gynaecology Physical Medicine and Rehabilitation Kadın Hastalıkları ve Doğum Fiziksel Tıp ve Rehabilitasyon Obstetric and neonatal outcomes in pregnant women with fibromyalgia syndrome: A retrospective case-control study https://orcid.org/0000-0002-5440-8621 Ertürk Çelik Gülsemin Gençlik ve Spor Bakanlığı 04 16 2026 17 57 52 58 11 07 2025 01 27 2026 Copyright © 2023, Interdisciplinary Medical Journal 2023 Interdisciplinary Medical Journal

Objective: This study aims to evaluate obstetric and neonatal outcomes in pregnant women diagnosed with fibromyalgia syndrome (FMS) and to investigate the relationship between disease severity and complications.Methods: This retrospective case-control study was conducted between August 2018 and August 2019. Sixty pregnant women diagnosed with FMS according to the 2016 ACR criteria were compared with 71 healthy pregnant women. FMS severity was assessed using the Widespread Pain Index (WPI) and Symptom Severity Scale (SSS). Obstetric complications, mode of delivery, and neonatal outcomes were recorded.Results: The mean age of pregnant women with FMS was significantly higher (30.8±4.6 vs 27.9±5.1 years, p=0.002). The preterm birth rate was 26.7% in the FMS group and 7.0% in the control group (p

 Fibromyalgia syndrome pregnancy preterm birth neonatal outcomes obstetric complications Wolfe F, Clauw DJ, Fitzcharles MA, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken). 2010;62(5):600-610. https://doi.org/10.1002/acr.20140 Queiroz LP. Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep. 2013;17(8):356. https://doi.org/10.1007/s11916-013-0356-5 Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311(15):1547-1555. https://doi.org/10.1001/jama.2014.3266 Häuser W, Ablin J, Fitzcharles MA, Littlejohn G, Luciano JV, Usui C, et al. Fibromyalgia. Nat Rev Dis Primers. 2015;1:15022. https://doi.org/10.1038/nrdp.2015.22 Ostensen M, Rugelsjøen A, Wigers SH. The effect of reproductive events and alterations of sex hormone levels on the symptoms of fibromyalgia. Scand J Rheumatol. 1997;26(5):355-360. https://doi.org/10.3109/03009749709065698 Buskila D, Neumann L, Alhoashle A, Abu-Shakra M. Fibromyalgia in men. Semin Arthritis Rheum. 2000 Aug;30(1):47-51. https://doi.org/10.1053/sarh.2000.8363 Zioni T, Buskila D, Aricha-Tamir B, Wiznitzer A, Sheiner E. Pregnancy outcome in patients with fibromyalgia syndrome. J Matern Fetal Neonatal Med. 2011;24(11):1325-1328. https://doi.org/10.3109/14767058.2010.551152 Chakrabarty S, Zoorob R. Fibromyalgia. Am Fam Physician. 2007;76(2):247-254. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319-329. https://doi.org/10.1016/j.semarthrit.2016.08.012 Ablin JN, Buskila D, Clauw DJ. Biomarkers in fibromyalgia. Curr Pain Headache Rep. 2009;13(5):343-349. https://doi.org/10.1007/s11916-009-0056-3 Goldenberg DL. Diagnosis and differential diagnosis of fibromyalgia. Am J Med. 2009;122(12 Suppl):S14-21. https://doi.org/10.1016/j.amjmed.2009.09.007 Buskila D, Sarzi-Puttini P. Fibromyalgia and pregnancy. Best Pract Res Clin Rheumatol. 2011;25(2):257-264. https://doi.org/10.1016/j.berh.2011.03.002 Heidari F, Afshari M, Moosazadeh M. Prevalence of fibromyalgia in general population and patients: a systematic review and meta-analysis. Rheumatol Int. 2017;37(9):1527-1539. https://doi.org/10.1007/s00296-017-3725-2 Magtanong GG, Spence AR, Czuzoj-Shulman N, Abenhaim HA. Maternal and neonatal outcomes among pregnant women with fibromyalgia: a population-based study of 12 million births. J Matern Fetal Neonatal Med. 2019;32(3):404-410. https://doi.org/10.1080/14767058.2017.1381684 Crofford LJ, Pillemer SR, Kalogeras KT, et al. Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum. 1994;37(11):1583-1592. https://doi.org/10.1002/art.1780371105 Martinez-Lavin M. Biology and therapy of fibromyalgia: stress, the stress response system, and fibromyalgia. Arthritis Res Ther. 2007;9(4):216. https://doi.org/10.1186/ar2146 Arnold LM, Clauw DJ, McCarberg BH; FibroCollaborative. Improving the recognition and diagnosis of fibromyalgia. Mayo Clin Proc. 2011;86(5):457-464. https://doi.org/10.4065/mcp.2010.0738 Gentile S, Fusco ML. Managing fibromyalgia syndrome in pregnancy no bridges between USA and EU. Arch Womens Ment Health. 2019 Dec;22(6):711-721. https://doi.org/10.1007/s00737-018-0933-z Bennett RM, Jones J, Turk DC, Russell IJ, Matallana L. An internet survey of 2,596 people with fibromyalgia. BMC Musculoskelet Disord. 2007;8:27. https://doi.org/10.1186/1471-2474-8-27 Jones GT, Atzeni F, Beasley M, Flüß E, Sarzi-Puttini P, Macfarlane GJ. The prevalence of fibromyalgia in the general population: a comparison of the American College of Rheumatology 1990, 2010, and modified 2010 classification criteria. Arthritis Rheumatol. 2015;67(2):568-575. https://doi.org/10.1002/art.38905 Clauw DJ, Hassett AL. The role of centralised pain in osteoarthritis. Clin Exp Rheumatol. 2017;35 Suppl 107(5):79-84. Kennedy M, Felson DT. A prospective long-term study of fibromyalgia syndrome. Arthritis Rheum. 1996;39(4):682-685. https://doi.org/10.1002/art.1780390422 Findeisen K, Guymer E, Littlejohn G. Neuroinflammatory and Immunological Aspects of Fibromyalgia. Brain Sci. 2025 Feb 17;15(2):206. https://doi.org/10.3390/brainsci15020206 Branco JC, Bannwarth B, Failde I, et al. Prevalence of fibromyalgia: a survey in five European countries. Semin Arthritis Rheum. 2010;39(6):448-453. https://doi.org/10.1016/j.semarthrit.2008.12.003 Wolfe F, Clauw DJ, Fitzcharles MA, et al. Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia. J Rheumatol. 2011;38(6):1113-1122. https://doi.org/10.3899/jrheum.100594 Ketenci S, Uzuner B, Durmuş D, et al. Frequency of idiopathic intracranial hypertension with ultrasound in patients with fibromyalgia: Relation with function, central sensitization, and neuropathic pain. Arthritis Care Res (Hoboken). 2010;62(5):600-610. https://doi.org/10.1002/acr.20140