Research Article
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Year 2016, Volume 75, Issue 1, 11 - 18, 15.05.2017

Abstract

References

  • Aebi H. (1984) Catalase in vitro. Methods in Enzymology, 105: 121-26.
  • Arda-Pirincci P., Oztay F., Bayrak B.B., Yanardag R. and Bolkent S. (2012) Teduglutide, a glucagon-like peptide 2 analogue: a novel protective agent with anti-apoptotic and anti-oxidant properties in mice with lung injury. Peptides, 38(2):238-47.
  • Beutler E. (1975) Glutathione in Red Cell Metabolism. A Manual of Biochemical Methods. 2nd Edition, Grune and Stratton, New York, USA.
  • Bowler R.P., Velsor L.W., Duda B., Chan E.D., Abraham E., Ware L.B., Matthay M.A. and Day B.J. (2003) Pulmonary edema fluid antioxidants are depressed in acute lung injury. Critical Care Medicine, 31(9):2309-15.

Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury

Year 2016, Volume 75, Issue 1, 11 - 18, 15.05.2017

Abstract

Effects of vitamin combination with selenium on acute lung injury in rats were examined in this study. Four experimental groups of rats were used as follows: group 1, animals administered intraperitoneally physiological saline solution; group 2, rats fed with vitamin C, vitamin E, beta-carotene and sodium selenate for three days; group 3, a single intraperitoneally injection of D-galactosamine (D-GaIN; 500 mg kg-1) into rats; group 4, animals fed with the antioxidant vitamin combination with selenium for three days, and administered D-GaIN. Lung tissues were examined using light microscope, and the following biochemical parameters were measured glutathione (GSH), lipid peroxidation (LPO) levels and tissue factor (TF), lactate dehydrogenase (LDH), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), paraoxonase (PON), myeloperoxidase (MPO), xanthine oxidase (XO) and sodium potassium ATPase (Na+/K+-ATPase) activities in lung tissues. Extensive edema in peripheral areas, mononuclear cell infiltrations around venules and locally a honeycomb-like structure were observed in the lung of group 3 rats. GSH, GPx and PON activities were decreased, whereas LPO level, TF, LDH, CAT, SOD, MPO and XO activities were increased in rats treated with D-GalN. Administration of the antioxidant combination protected lung tissue against damage by enhancing biochemical chances and pulmonary edema in group 3 animals, while no significant effect on protection of pulmonary inflammation was observed. In conclusion, the antioxidant vitamin supplementation with selenium can be used in the prevention of acute lung injury.

References

  • Aebi H. (1984) Catalase in vitro. Methods in Enzymology, 105: 121-26.
  • Arda-Pirincci P., Oztay F., Bayrak B.B., Yanardag R. and Bolkent S. (2012) Teduglutide, a glucagon-like peptide 2 analogue: a novel protective agent with anti-apoptotic and anti-oxidant properties in mice with lung injury. Peptides, 38(2):238-47.
  • Beutler E. (1975) Glutathione in Red Cell Metabolism. A Manual of Biochemical Methods. 2nd Edition, Grune and Stratton, New York, USA.
  • Bowler R.P., Velsor L.W., Duda B., Chan E.D., Abraham E., Ware L.B., Matthay M.A. and Day B.J. (2003) Pulmonary edema fluid antioxidants are depressed in acute lung injury. Critical Care Medicine, 31(9):2309-15.

Details

Primary Language English
Subjects Science
Journal Section Research Articles
Authors

Tunç Çatal This is me

Publication Date May 15, 2017
Submission Date May 16, 2017
Acceptance Date
Published in Issue Year 2016, Volume 75, Issue 1

Cite

Bibtex @research article { iufsjb313193, journal = {European Journal of Biology}, issn = {2602-2575}, eissn = {2618-6144}, address = {}, publisher = {Istanbul University}, year = {2017}, volume = {75}, number = {1}, pages = {11 - 18}, title = {Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury}, key = {cite}, author = {Çatal, Tunç} }
APA Çatal, T. (2017). Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury . European Journal of Biology , 75 (1) , 11-18 . Retrieved from https://dergipark.org.tr/en/pub/iufsjb/issue/29257/313193
MLA Çatal, T. "Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury" . European Journal of Biology 75 (2017 ): 11-18 <https://dergipark.org.tr/en/pub/iufsjb/issue/29257/313193>
Chicago Çatal, T. "Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury". European Journal of Biology 75 (2017 ): 11-18
RIS TY - JOUR T1 - Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury AU - TunçÇatal Y1 - 2017 PY - 2017 N1 - DO - T2 - European Journal of Biology JF - Journal JO - JOR SP - 11 EP - 18 VL - 75 IS - 1 SN - 2602-2575-2618-6144 M3 - UR - Y2 - 2023 ER -
EndNote %0 European Journal of Biology Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury %A Tunç Çatal %T Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury %D 2017 %J European Journal of Biology %P 2602-2575-2618-6144 %V 75 %N 1 %R %U
ISNAD Çatal, Tunç . "Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury". European Journal of Biology 75 / 1 (May 2017): 11-18 .
AMA Çatal T. Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury. Eur J Biol. 2017; 75(1): 11-18.
Vancouver Çatal T. Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury. European Journal of Biology. 2017; 75(1): 11-18.
IEEE T. Çatal , "Efficacy of antioxidant vitamins (vitamin C, vitamin E, beta-carotene) and selenium supplement on D-galactosamine-induced lung injury", European Journal of Biology, vol. 75, no. 1, pp. 11-18, May. 2017