i̇st tıp fak derg

Journal of Istanbul Faculty of Medicine

1305-6441

Istanbul University

TÜYLÜ HÜCRELİ LÖSEMİ TANILI İKİ OLGUDA BİRİNCİ DİZİ VE NÜKSTE KLADRİBİN UYGULAMASI

Yönal

İpek

Coşkun

Raif

Hindilerden

Fehmi

Özcan

Erkan

Doğan

Öner

Yavuz

Selim

Nalçacı

Meliha

02 08 2012

74 4 66 71 02 08 2012

1916

Journal of Istanbul Faculty of Medicine

Tüylü hücreli lösemi (THL) birinci dizi ve nükste purin nükleozid analoğu olan kladribin (2-klorodeoksiadenozin) ile tedavi edilebilen nadir görülen kronik seyirli lenfoproliferatif hastalıktır. Bu yazıda THL tanısı ile kladribin uygulanarak tam remisyon (TR) elde edilmiş ve tanının 6. yılında nüks nedeniyle tekrar kladribin uygulanması sonrası 3. ayda kemik iliği biyopsisinde retikülin liflerinin kaybolduğu, tüylü lösemi hücrelerinin de saptanmadığı (tekrar TR elde edilen) bir olgu ve THL tanısı ile kladribin uygulanarak TR elde edilen, tanının 14. yılında nüks THL tanısıyla kladribin uygulanmasının 23. gününde nötropenik ateş, candida pnömonisi ve septik şok sonucu eks olan ikinci bir olgu bildirilmektedir.

Tüylü hücreli lösemi nüks tüylü hücreli lösemi kladribin (2-klorodeoksiadenozin)

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İstanbul Tıp Fakültesi Dergisi Cilt / Volume: 71 • Sayı / Number: 4 • Yıl/Year: 2011