Extracts and eudesmanolides from Artemisia santonicum were tested for their antiprotozoal and antifungal activities. 8 α-hydroxytaurin was active against Leishmania donovani at 100 mcg/ml. The genus Artemisia (Compositae) has been represented by twentythree species in Flora of Turkey and is distrubuted mainly in Eastern and Central Ana-tolia (1,2). Mai~y species of Ai-tenzisia have been used in folk medicine (3). Well known is the authelmintic activity of several species. This work is one of a series on the bioactivity of Turkish Al-temisia (4,5). Here we report antiprotozoal and antifungal activities of extracts and components previously isolated and determined from A.santo~zicum (6).
1. Cullen, J., Artemisia in Davis, P.H., Flora of Turkey and the East Aegean Islands, vol. 5, pp.
31 1-324, University Press, Edinburgh (1975).
MIC (pg/mI)
2. Davis, P.H., Mill, R.R., Tan, K., Flora of Turkey and the East Aegean Islands (supplement),
vol. 10, pp. 163, University Press, Edinburgh (1988).
3. Cubukgu, B., Ozhatay, N., "Investigation of Anatolian Folk Medicine" in Proceedings of
The Third International Turkish Folklore Congress, vol. 4, p. 103-115, Bagbakanlik
Bas~mevi, Ankara (1987).
Leishmania donovani
500
-
-
100
250
-
500
-
5
Entamoeba histDlytiea
500
500
500
500
250
250
500
5
-
7. Favel, A., Steinrnetz, M.D., Regli, P., Vidal-Ollivier, E., Elias, R., Balansard, G., Planta
Medica, 60,50-53 (1994).
8. Audipert, P., Placidi, M., Giovannangeli, G., Cristay, B., Gasquet, M., Delmas, F., Andrac,
A., Timon-David, P., Ann. Pharm. Fr., 37,483-490 (1979).
9. Cavier, R., Cenac, J., Bull.Soc.Path.Exot.; 65,399-404 (1972).
10. Taylor, E.R.A., Baker, R.J., The cultivation of parasites in vitro, Ed. Blackwell Scientific
Publication Oxford and Edinburgh (1968)..
11. Sauvain, M., "Etiide des plarlres anriparasiiaires du platealt'des Gzcyanes: a~ztipaludiqlces er
alztileisl~mar~iens", Thkse de Doctorat en Sciences Phmaceutiques, UniversitC de Paris
Sud (1989).
EVALUATION OF ANTIPROTOZOAL AND ANTZFUNGAL ACTIVITIES OF TURKISH ARTEMZSZA SANTONICUM L.
Extracts and eudesmanolides from Artemisia santonicum were tested for their antiprotozoal and antifungal activities. 8 α-hydroxytaurin was active against Leishmania donovani at 100 mcg/ml. The genus Artemisia (Compositae) has been represented by twentythree species in Flora of Turkey and is distrubuted mainly in Eastern and Central Ana-tolia (1,2). Mai~y species of Ai-tenzisia have been used in folk medicine (3). Well known is the authelmintic activity of several species. This work is one of a series on the bioactivity of Turkish Al-temisia (4,5). Here we report antiprotozoal and antifungal activities of extracts and components previously isolated and determined from A.santo~zicum (6).
1. Cullen, J., Artemisia in Davis, P.H., Flora of Turkey and the East Aegean Islands, vol. 5, pp.
31 1-324, University Press, Edinburgh (1975).
MIC (pg/mI)
2. Davis, P.H., Mill, R.R., Tan, K., Flora of Turkey and the East Aegean Islands (supplement),
vol. 10, pp. 163, University Press, Edinburgh (1988).
3. Cubukgu, B., Ozhatay, N., "Investigation of Anatolian Folk Medicine" in Proceedings of
The Third International Turkish Folklore Congress, vol. 4, p. 103-115, Bagbakanlik
Bas~mevi, Ankara (1987).
Leishmania donovani
500
-
-
100
250
-
500
-
5
Entamoeba histDlytiea
500
500
500
500
250
250
500
5
-
7. Favel, A., Steinrnetz, M.D., Regli, P., Vidal-Ollivier, E., Elias, R., Balansard, G., Planta
Medica, 60,50-53 (1994).
8. Audipert, P., Placidi, M., Giovannangeli, G., Cristay, B., Gasquet, M., Delmas, F., Andrac,
A., Timon-David, P., Ann. Pharm. Fr., 37,483-490 (1979).
9. Cavier, R., Cenac, J., Bull.Soc.Path.Exot.; 65,399-404 (1972).
10. Taylor, E.R.A., Baker, R.J., The cultivation of parasites in vitro, Ed. Blackwell Scientific
Publication Oxford and Edinburgh (1968)..
11. Sauvain, M., "Etiide des plarlres anriparasiiaires du platealt'des Gzcyanes: a~ztipaludiqlces er
alztileisl~mar~iens", Thkse de Doctorat en Sciences Phmaceutiques, UniversitC de Paris
Sud (1989).
There are 11 citations in total.
Details
Primary Language
English
Subjects
Pharmacology and Pharmaceutical Sciences
Journal Section
Makaleler
Authors
B.cubukcu*,.m.gasquet**,f. Delmas** A. Favel**,a.h.meriçli*,r.elıas**,g.balansard**
This is me
A. Favel**,a.h.meriçli*,r.elıas**,g.balansard**, B. D. (2015). EVALUATION OF ANTIPROTOZOAL AND ANTZFUNGAL ACTIVITIES OF TURKISH ARTEMZSZA SANTONICUM L. Journal of Faculty of Pharmacy of Istanbul University, 32, 29-32.
AMA
A. Favel**,a.h.meriçli*,r.elıas**,g.balansard** BD. EVALUATION OF ANTIPROTOZOAL AND ANTZFUNGAL ACTIVITIES OF TURKISH ARTEMZSZA SANTONICUM L. Journal of Faculty of Pharmacy of Istanbul University. September 2015;32:29-32.
Chicago
A. Favel**,a.h.meriçli*,r.elıas**,g.balansard**, B.cubukcu*,.m.gasquet**,f. Delmas**. “EVALUATION OF ANTIPROTOZOAL AND ANTZFUNGAL ACTIVITIES OF TURKISH ARTEMZSZA SANTONICUM L”. Journal of Faculty of Pharmacy of Istanbul University 32, September (September 2015): 29-32.
EndNote
A. Favel**,a.h.meriçli*,r.elıas**,g.balansard** BD (September 1, 2015) EVALUATION OF ANTIPROTOZOAL AND ANTZFUNGAL ACTIVITIES OF TURKISH ARTEMZSZA SANTONICUM L. Journal of Faculty of Pharmacy of Istanbul University 32 29–32.
IEEE
B. D. A. Favel**,a.h.meriçli*,r.elıas**,g.balansard**, “EVALUATION OF ANTIPROTOZOAL AND ANTZFUNGAL ACTIVITIES OF TURKISH ARTEMZSZA SANTONICUM L”., Journal of Faculty of Pharmacy of Istanbul University, vol. 32, pp. 29–32, 2015.
ISNAD
A. Favel**,a.h.meriçli*,r.elıas**,g.balansard**, B.cubukcu*,.m.gasquet**,f. Delmas**. “EVALUATION OF ANTIPROTOZOAL AND ANTZFUNGAL ACTIVITIES OF TURKISH ARTEMZSZA SANTONICUM L”. Journal of Faculty of Pharmacy of Istanbul University 32 (September 2015), 29-32.
JAMA
A. Favel**,a.h.meriçli*,r.elıas**,g.balansard** BD. EVALUATION OF ANTIPROTOZOAL AND ANTZFUNGAL ACTIVITIES OF TURKISH ARTEMZSZA SANTONICUM L. Journal of Faculty of Pharmacy of Istanbul University. 2015;32:29–32.
MLA
A. Favel**,a.h.meriçli*,r.elıas**,g.balansard**, B.cubukcu*,.m.gasquet**,f. Delmas**. “EVALUATION OF ANTIPROTOZOAL AND ANTZFUNGAL ACTIVITIES OF TURKISH ARTEMZSZA SANTONICUM L”. Journal of Faculty of Pharmacy of Istanbul University, vol. 32, 2015, pp. 29-32.
Vancouver
A. Favel**,a.h.meriçli*,r.elıas**,g.balansard** BD. EVALUATION OF ANTIPROTOZOAL AND ANTZFUNGAL ACTIVITIES OF TURKISH ARTEMZSZA SANTONICUM L. Journal of Faculty of Pharmacy of Istanbul University. 2015;32:29-32.