Association between apolipoprotein E polymorphisms and gastric cancer in a hospital-based Turkish population

Year 2017, Volume: 47 Issue: 3, 97 - 100, 11.10.2017

Tuğcan Korak , Nihal Üren Emel Ergül Turgay Şimşek Ali Sazcı Nuh Zafer Cantürk Nihat Zafer Utkan

https://doi.org/10.5152/IstanbulJPharm.2017.0015

Abstract

Apolipoprotein E (ApoE)
is an important secretory glycoprotein, and also a ligand for LDL receptors and
ApoE receptors. It is involved in lipid transport and catabolism, nerve
regeneration, immune system regulation, and cell proliferation. Moreover, both
the causative and protective effects of APOE polymorphic variants and alleles
have been correlated with several diseases, including cancer types such as
gastric cancer. However, to the best of our knowledge, no data are available
describing the association between gastric cancer and APOE polymorphisms in the
Turkish population. In this context, this study was conducted to evaluate the
association between the genotypes of APOE and the risk of gastric cancer and
also to demonstrate the allele frequencies and genotype distributions of APOE
gene in a hospital-based Turkish population with gastric cancer. A total of 59
patients with gastric cancer and 200 healthy controls were included in this
study. Results showed the absence of any statistically significant association
between APOE gene polymorphisms and the risk of gastric cancer (χ2
=2.711, p=0.744), which could possibly be due to the small sample size of our
study. Therefore, further investigations such as expression studies and
meta-analysis comprising larger sample size and detailed demographic data are
necessary to identify the alleles of APOE gene associated with the risk of
gastric cancer. 

Keywords

Gastric Cancer, ApoE polymorphisms, Turkish population

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