Research Article
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Year 2018, Volume 48, Issue 3, 73 - 75, 01.12.2018

Abstract

References

  • Reference1Berkov S, Bastida J, Nikolova M, Viladomat F, Codina C (2008). Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts. Phytochemical Analysis doi: 10.1002/pca.1066.
  • Reference2Berkov S, Bastida J, Tsvetkova R, Viladomat F, Codina C (2009). Alkaloids from Sternbergia colchiciflora. Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences 64: 311-316.
  • Reference3Berkov S, Sidjimova B, Evstatieva L, Popov S (2004). Intraspecific variability in the alkaloid metabolism of Galanthus elwesii. Phytochemistry 65: 579-586.
  • Reference4Bozkurt-Sarikaya B, Kaya GI, Onur MA, Bastida J, Berkov S, Unver-Somer N (2014). GC/MS Analysis of Amaryllidaceae Alkaloids in Galanthus gracilis. Chemistry of Natural Compounds 50: 573-575.
  • Reference5Bozkurt B, Emir A, Kaya GI, Onur MA, Berkov S, Bastida J, Unver Somer N (2017). Alkaloid profiling of Galanthus woronowii Losinsk. by GC-MS and evaluation of its biological activity. Marmara Pharmaceutical Journal doi: 10.12991/mpj.2017.12.
  • Reference6Conforti F, Loizzo MR, Marrelli M, Menichini F, Statti GA, Uzunov D, Menichini F (2010). Quantitative determination of Amaryllidaceae alkaloids from Galanthus reginae-olgae subsp vernalis and in vitro activities relevant for neurodegenerative diseases. Pharmaceutical Biology 48: 2-9.
  • Reference7Davis AP (2006). Snowdrops, A Monograph of Cultivated Galanthus. In: The Genus Galanthus – Snowdrops in the wild. , Griffin Press Publishing Ltd.
  • Reference8Evans WC, Evans D, Trease GE (2002). Trease and Evans Pharmacognosy. fifteenth ed, Edinburgh, New York, W B Saunders.
  • Reference9Gabrielsen B, Monath TP, Huggins JW, Kefauver DF, Pettit GR, Groszek G, Hollingshead M, Kirsi JJ, Shannon WM, Schubert EM, Dare J, Ugarkar B, Ussery MA, Phelan MJ (1992). Antiviral (Rna) Activity of Selected Amaryllidaceae Isoquinoline Constituents and Synthesis of Related Substances. Journal of Natural Products doi: Doi 10.1021/Np50089a003.
  • Reference10Lopez S, Bastida J, Viladomat F, Codina C (2002). Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts. Life Sciences doi: 10.1016/S0024-3205(02)02034-9.
  • Reference11Noyan S, Rentsch GH, Onur MA, Gozler T (1998). The gracilines: A novel subgroup of the amaryllidaceae alkaloids. Heterocycles 48: 1777-1791.
  • Reference12Sarıkaya BB, Berkov S, Bastida J, Kaya GI, Unver-Somer N (2013). GC-MS Investigation of Amaryllidaceae Alkaloids in Galanthus xvalentine nothosubsp. subplicatus. Natural Product Communications 8: 327-328.
  • Reference13Sarikaya BB, Somer NU, Kaya GI, Onur MA, Bastida J, Berkov S (2013). GC-MS Investigation and Acetylcholinesterase Inhibitory Activity of Galanthus rizehensis. Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences 68: 118-124.
  • Reference14Unver N, Kaya GI (2005). An unusual pentacyclic dinitrogenous alkaloid from Galanthus gracilis. Turkish Journal of Chemistry 29: 547-553.
  • Reference15Unver N, Noyan S, Gozler T, Onur MA, Gozler B, Hesse M (1999). Three new tazettine-type alkaloids from Galanthus gracilis and Galanthus plicatus subsp byzantinus. Planta Medica 65: 347-350.

Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS

Year 2018, Volume 48, Issue 3, 73 - 75, 01.12.2018

Abstract

DOI: 10.26650/IstanbulJPharm.2018.422525


Galanthus L. is generally acknowledged as a valuable biological source due to its Amaryllidaceae alkaloids with unusual chemical structures and a wide variety of biological activities. Among these alkaloids, galanthamine is the first example of their practical application in medicine as a potent and selective inhibitor of the enzyme acetylcholinesterase, and already present on the market as a therapeutic agent for Alzheimer’s disease. Lycorine is the main Amaryllidaceae alkaloid deeply investigated for its biological activity for many years. In this study the alkaloidal profile of G. gracilis collected from western Aegean (Alankıyı/Bayındır) will be illustrated for the first time. GC-MS profiling was carried out on the crude alkaloidal extract obtained from dried and powdered plant material. 11 alkaloids were detected by GC-MS, including graciline, demethylhomolycorine and tazettine as the major ones.

References

  • Reference1Berkov S, Bastida J, Nikolova M, Viladomat F, Codina C (2008). Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts. Phytochemical Analysis doi: 10.1002/pca.1066.
  • Reference2Berkov S, Bastida J, Tsvetkova R, Viladomat F, Codina C (2009). Alkaloids from Sternbergia colchiciflora. Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences 64: 311-316.
  • Reference3Berkov S, Sidjimova B, Evstatieva L, Popov S (2004). Intraspecific variability in the alkaloid metabolism of Galanthus elwesii. Phytochemistry 65: 579-586.
  • Reference4Bozkurt-Sarikaya B, Kaya GI, Onur MA, Bastida J, Berkov S, Unver-Somer N (2014). GC/MS Analysis of Amaryllidaceae Alkaloids in Galanthus gracilis. Chemistry of Natural Compounds 50: 573-575.
  • Reference5Bozkurt B, Emir A, Kaya GI, Onur MA, Berkov S, Bastida J, Unver Somer N (2017). Alkaloid profiling of Galanthus woronowii Losinsk. by GC-MS and evaluation of its biological activity. Marmara Pharmaceutical Journal doi: 10.12991/mpj.2017.12.
  • Reference6Conforti F, Loizzo MR, Marrelli M, Menichini F, Statti GA, Uzunov D, Menichini F (2010). Quantitative determination of Amaryllidaceae alkaloids from Galanthus reginae-olgae subsp vernalis and in vitro activities relevant for neurodegenerative diseases. Pharmaceutical Biology 48: 2-9.
  • Reference7Davis AP (2006). Snowdrops, A Monograph of Cultivated Galanthus. In: The Genus Galanthus – Snowdrops in the wild. , Griffin Press Publishing Ltd.
  • Reference8Evans WC, Evans D, Trease GE (2002). Trease and Evans Pharmacognosy. fifteenth ed, Edinburgh, New York, W B Saunders.
  • Reference9Gabrielsen B, Monath TP, Huggins JW, Kefauver DF, Pettit GR, Groszek G, Hollingshead M, Kirsi JJ, Shannon WM, Schubert EM, Dare J, Ugarkar B, Ussery MA, Phelan MJ (1992). Antiviral (Rna) Activity of Selected Amaryllidaceae Isoquinoline Constituents and Synthesis of Related Substances. Journal of Natural Products doi: Doi 10.1021/Np50089a003.
  • Reference10Lopez S, Bastida J, Viladomat F, Codina C (2002). Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts. Life Sciences doi: 10.1016/S0024-3205(02)02034-9.
  • Reference11Noyan S, Rentsch GH, Onur MA, Gozler T (1998). The gracilines: A novel subgroup of the amaryllidaceae alkaloids. Heterocycles 48: 1777-1791.
  • Reference12Sarıkaya BB, Berkov S, Bastida J, Kaya GI, Unver-Somer N (2013). GC-MS Investigation of Amaryllidaceae Alkaloids in Galanthus xvalentine nothosubsp. subplicatus. Natural Product Communications 8: 327-328.
  • Reference13Sarikaya BB, Somer NU, Kaya GI, Onur MA, Bastida J, Berkov S (2013). GC-MS Investigation and Acetylcholinesterase Inhibitory Activity of Galanthus rizehensis. Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences 68: 118-124.
  • Reference14Unver N, Kaya GI (2005). An unusual pentacyclic dinitrogenous alkaloid from Galanthus gracilis. Turkish Journal of Chemistry 29: 547-553.
  • Reference15Unver N, Noyan S, Gozler T, Onur MA, Gozler B, Hesse M (1999). Three new tazettine-type alkaloids from Galanthus gracilis and Galanthus plicatus subsp byzantinus. Planta Medica 65: 347-350.

Details

Primary Language English
Subjects Health Care Sciences and Services
Journal Section Original Article
Authors

Çiğdem KARAKOYUN> (Primary Author)
EGE ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
0000-0003-1150-7061
Türkiye

Publication Date December 1, 2018
Submission Date May 10, 2018
Acceptance Date October 15, 2018
Published in Issue Year 2018, Volume 48, Issue 3

Cite

Bibtex @research article { iujp422525, journal = {İstanbul Journal of Pharmacy}, eissn = {2587-2087}, address = {İstanbul Üniversitesi Eczacılık Fakültesi Farmasötik Botanik AD}, publisher = {Istanbul University}, year = {2018}, volume = {48}, number = {3}, pages = {73 - 75}, title = {Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS}, key = {cite}, author = {Karakoyun, Çiğdem} }
APA Karakoyun, Ç. (2018). Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS . İstanbul Journal of Pharmacy , 48 (3) , 73-75 . Retrieved from https://dergipark.org.tr/en/pub/iujp/issue/42527/422525
MLA Karakoyun, Ç. "Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS" . İstanbul Journal of Pharmacy 48 (2018 ): 73-75 <https://dergipark.org.tr/en/pub/iujp/issue/42527/422525>
Chicago Karakoyun, Ç. "Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS". İstanbul Journal of Pharmacy 48 (2018 ): 73-75
RIS TY - JOUR T1 - Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS AU - ÇiğdemKarakoyun Y1 - 2018 PY - 2018 N1 - DO - T2 - İstanbul Journal of Pharmacy JF - Journal JO - JOR SP - 73 EP - 75 VL - 48 IS - 3 SN - -2587-2087 M3 - UR - Y2 - 2018 ER -
EndNote %0 İstanbul Journal of Pharmacy Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS %A Çiğdem Karakoyun %T Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS %D 2018 %J İstanbul Journal of Pharmacy %P -2587-2087 %V 48 %N 3 %R %U
ISNAD Karakoyun, Çiğdem . "Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS". İstanbul Journal of Pharmacy 48 / 3 (December 2018): 73-75 .
AMA Karakoyun Ç. Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS. iujp. 2018; 48(3): 73-75.
Vancouver Karakoyun Ç. Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS. İstanbul Journal of Pharmacy. 2018; 48(3): 73-75.
IEEE Ç. Karakoyun , "Alkaloid profiling in Galanthus gracilis Celak. from western Turkey by GC/MS", İstanbul Journal of Pharmacy, vol. 48, no. 3, pp. 73-75, Dec. 2018