Research Article
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Year 2021, Volume: 51 Issue: 3, 357 - 364, 29.12.2021

Abstract

Project Number

52245

References

  • • Abubaker, S. R., & Hidayat, H. J. (2015). Anti-tumor potential of local aslerk (Eremurus spectabilis) leaf extracts by HPLC and applying on cancer cell lines in vitro. Iraqi Journal of Cancer and Medical Genetics, 8(2), 123-128.
  • • Acıkara, Ö. B., Ilhan, M., Kurtul, E., Šmejkal, K., & Küpeli Akkol, E. (2019). Inhibitory activity of Podospermum canum and its active components on collagenase, elastase and hyaluronidase enzymes. Bioorganic Chemistry, 93, 103330.
  • • Al-Dabbas M. M., Kitahara K., Suganuma T., Hasimato F., & Tadera K. (2006). Antioxidant and alpha-amylase inhibitory compounds from aerial parts of Varthemia iphionoides Boiss. Bioscience Biotechnology and Biochemistry, 70, 2178-2174.
  • • Apraj, V. D., & Pandita, N. S. (2016). Evaluation of skin anti‑aging potential of Citrus reticulata blanco peel. Pharmacognosy Research, 8(3), 160-168.
  • • Aysu, T., Demirbas, A., Bengü, A. Ş., & Küçük, M. M. (2015). Evaluation of Eremurus spectabilis for production of bio-oils with supercritical solvents. Process Safety and Environmental Protection, 94, 339-349.
  • • Behm, B., Schreml, S., Landthaler, M., & Babilas, P. (2012). Skin signs in diabetes mellitus. Journal of the European Academy of Dermatology and Venereology, 26(10), 1203-1211.
  • • Beiranvand, M., & Beiranvand, F. (2021). Iranian plant Eremurus persicus: an overview of botany, traditional uses, phytochemistry and pharmacology. Natural Product Research, http://dx.doi.org/10.108 0/14786419.2021.1916744
  • • Bircan, B., & Kırbağ, S. (2015). Determination of antioxidant and antimicrobial properties of Eremurus spectabilis Bieb. Artvin Coruh University Journal of Forestry Faculty, 16(2), 176-186. ISSN:2146- 1880, e-ISSN: 2146-698X
  • • Bonamonte, D., & Filoni, A. (2021). Impact of endocrine disorders on skin disorders. In Portincasa, P., Frühbeck, G., & Nathoe, H.M. (Eds.), Endocrinology and systemic diseases. Endocrinology. (pp. 399-435). Springer, Cham.
  • • Buhren, B. A., Schrumpf, H., Gorges, K., Reiners, O., Bölke, E., Fischer, J. W., Homey, B., & Gerber, P. A. (2020). Dose- and time-dependent effects of hyaluronidase on structural cells and the extracellular matrix of the skin. European Journal of Medicinal Research, 25, 60.
  • • Celik Onar, H., Yusufoglu, A., Turker, G., & Yanardag R. (2012). Elastase, tyrosinase and lipoxygenase inhibition and antioxidant activity of an aqueous extract from Epilobium angustifolium L. leaves. Journal of Medicinal Plants Research, 6(5), 716-726.
  • • Chiocchio, I., Mandrone, M., Sanna, C., Maxia, A., Tacchini, M., & Poli, F. (2018). Screening of a hundred plant extracts as tyrosinase and elastase inhibitors, two enzymatic targets of cosmetic interest. Industrial Crops and Products, 122, 498-505.
  • • Cinar, A., Tugrul Ay, S., Ayas, F., Karabak, S., Guzelsoy, N., & Ucurum, O. (2017). Foxtail lilly (Eremurus spectabilis M. Bieb.) as priority species biodiversity for food and nutrition project of Turkey. Anadolu Journal of Aegean Agricultural Research Institute, 27(2), 69-73.
  • • Dashti, M., Tavakoli, H., Zarif Ketabi, H., & Paryab, A. (2005). Study of ecological requirements of plant of Eremurus (Eremurus spectabilis M.B.) in Khorasan province. Iranian Journal of Range and Desert Research, 12(2),153-165.
  • • de Maceto, G. M., Nunes, S., & Barreto, T. (2016). Skin disorders in diabetes mellitus: An epidemiology and physiopathology review. Diabetology & Metabolic Syndrome, 8, 63.
  • • Demirkesen, C. (2015). Skin manifestations of endocrine diseases. Turkish Journal of Pathology, 31(Supp l), 145-154.
  • • Deniz, F. S. S., Salmas, R. E., Emerce, E., Cankaya, I. I. T., Yusufoglu, H. S., & Orhan, I. E. (2020). Evaluation of collagenase, elastase and tyrosinase inhibitory activities of Cotinus coggygria Scop. Through in vitro and in silico approach. South African Journal of Botany, 132, 277-288.
  • • Desmiaty, Y., Mulatsari, E., Saputri, F. C., Hanafi, M., Prastiwi, R., & Elya, B. (2020). Inhibition of pancreatic elastase in silico and in vitro by Rubus rosifolius leaves extract and its constituents. Journal of Pharmacy & Bioallied Science, 12(3), 317-323.
  • • Etsassala, N. G. E. R., Badmus, J. A., Waryo, T. T., Marnewick, J. L., Cupido, C. N., Hussein, A. A., & Iwuoha, E. I. (2019). Alpha-glucosidase and alpha-amylase inhibitory activities of novel abietane diterpenes from Salvia africana-lutea. Antioxidants (Basel), 8(10), 421.
  • • Gaggeri, R., Rossi, D., Azzolina, O., Ahmed, K. M., Avanzini, A., Mantelli, M., Gozzini, D., Paolillo, M. & Collina, S. (2013). Anti-inflammatory properties of ethanolic root extract of Eremurus persicus (Jaub and Spach) Boiss, a Kurdish herbal remedy. Journal of Medicinal Plant Research, 7, 1730-1735.
  • • Gaggeri, R., Rossi, D., Mahmood, K., Gozzini, D., Mannucci, B., Corana, F., Daglia, M., Avanzini, A., Mantelli, M., Martino, E., & Collina, S. (2015). Towards elucidating Eremurus root remedy: Chemical profiling and preliminary biological investigations of Eremurus persicus and Eremurus spectabilis root ethanolic extracts, Journal of Medicinal Plant Research, 8(41), 1038-1048.
  • • Gangadharan, A., Jacob, E., & Densely Jose, D. (2014). Phytochemical analysis, antibacterial and antihyaluronidase activity of three indigenous medicinal plants. World Journal of Pharmacy and Pharmaceutical Sciences, 3(6), 752-761.
  • • Genc, Y., Guragac Dereli, F. T., Saracoglu, I., & Kupeli Akkol, E. (2020). The inhibitory effects of isolated constituents from Plantago major subsp. major L. on collagenase, elastase and hyaluronidase enzymes: Potential wound healer. Saudi Pharmaceutical Journal, 28(1), 101-106.
  • • Gholamhoseinian, A., Hossein, F., Fariba, S., & Mirtaj Aldini, S. M. (2008). The inhibitory effect of some Iranian plants extracts on the alpha glucosidase. Iranian Journal of Basic Medical Science, 11(1), 1-9.
  • • Girish, K. S., & Kemparaju, K. (2007). The magic glue hyaluronan and its eraser hyaluronidase: A biological overview. Life Sciences, 80(21), 1921-1943.
  • • Gong, L., Feng, D., Wang, T., Ren, Y., Liu, Y., & Wang, J. (2020). Inhibitors of α-amylase and α-glucosidase: Potential linkage for whole cereal foods on prevention of hyperglycemia. Food Science & Nutrition, 8(12), 6320-6337.
  • • Karaoglan Esen, S., Gundogdu, G., Secme, M., Onur, S., Demirkaya Miloglu, F., Dodurga, Y., & Tufekci A. R. (2018). Eremurus spectabilis, rich source of isoorientin: isolation, quantification and anti-cancer activity on SH-SY5Y neuroblastoma cells. Current Pharmaceutical Analysis, 14(6), 578-585.
  • • Kumud, M., & Sanju, N. (2018). In-vitro evaluation of antioxidant, anti-elastase, anti-collagenase, anti-hyaluronidase activities of safranal and determination of its sun protection factor in skin photoaging. Bioorganic Chemistry, 77, 159-167.
  • • Lai, C. C. K., Nor, N. M., Kamaruddin, N. A., Jamil, A., & Safian, N. (2021). Comparison of transepidermal water loss and skin hydration in diabetics and nondiabetics. Clinical and Experimental Dermatology, 46(1), 58-64.
  • • Lankatillake, C., Luo, S., Flavel, M., Lenon, G. B., Gill, H., Huynh, T., & Dias, D. A. (2021). Screening natural product extracts for potential enzyme inhibitors: protocols, and the standardization of the usage of blanks in α-amylase, α-glucosidase, and lipase assays. Plant Methods 17, 3.
  • • Lee, K. K., Kim, J. H., Cho, J. J., & Choi, J. D. (1999). Inhibitory effects of 150 plant extracts on elastase activity, and their anti-inflammatory effects. International Journal of Cosmetic Science, 21, 71-82.
  • • Li, Z., & Ma, S. (2017). Recent advances in synthetic α-glucosidase inhibitors. ChemMedChem, 12(11), 819-829.
  • • Marrelli, M., Statti, G., & Conforti, F. (2020). A review of biologically active natural products from Mediterranean wild edible plants: Benefits in the treatment of obesity and its related disorders. Molecules, 25(3), 649.
  • • Mendes, A. L., Miot, H. A., & Haddad Junior, V. (2017). Diabetes mellitus and the skin. Anais Brasileiros De Dermatologia, 92(1), 8-20.
  • • Moon, J. Y., Yim, E. Y., Song, G., Lee, N. H., & Hyun, C. G. (2010). Screening of elastase and tyrosinase inhibitory activity from Jeju Island plants. Eurasian Journal of Biosciences, 4(1), 41-53.
  • • Mottaghipisheh, J., Kúsz, N., Hohmann, J., Tsai, Y. C., & Csupor, D. (2021). Isolation of secondary metabolites from the Iranian medicinal plant Eremurus persicus. Zeitschrift für Naturforschung, 76(1- 2), 43-47.
  • • Okyar, A., Can, A., Akev, N., Baktir, N., & Sutlupinar, N. (2001). Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models. Phytotheraphy Research, 15(2), 157-161.
  • • Pant, D. R., Aryal, B., Pun, D., Sharma, S. & Joshi, G. P. (2021). Inhibition of α-amylase and α -glucosidase activities in vitro by extracts of selected medicinal plants. Biodiversitas Journal of Biological Diversity, 22(3), 1187-1193.
  • • Papoutsis, K., Zhang, J., Bowyer, M. C., Brunton, N., Gibney, E. R., & Lyng, J. (2021). Fruit, vegetables, and mushrooms for the preparation of extracts with α-amylase and α-glucosidase inhibition properties: A review. Food Chemistry, 338, 128119.
  • • Pillaiyar, T., Manickam, M., & Namasivayam, V. (2017). Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 403-425.
  • • Sacan, O., Akev, N., & Yanardag, R. (2017). In vitro inhibitory effect of Aloe vera (L.) Burm. f. leaf extracts on the activity of some enzymes and antioxidant activity. Indian Journal of Biochemistry & Biophysics, 54, 82-89.
  • • Salehi, B., Ayatollahi, S. A., Segura-Carretero, A., Kobarfard, F., Contreras, M. D. M., Faizi, M., Sharifi-Rad, M., Tabatabai, S. A., & Sharifi- Rad, J. (2017). Bioactive chemical compounds in Eremurus persicus (Joub. & Spach) Boiss. essential oil and their health implications. Cellular and Molecular Biology, 63, 1-7.
  • • Svoboda, S. A., & Shields, B. E. (2021). Cutaneous manifestations of nutritional excess: Pathophysiologic effects of hyperglycemia and hyperinsulinemia on the skin. Cutis, 107, 74-78.
  • • Tao, Y., Zhang, Y., Cheng, Y., & Wang, Y. (2013). Rapid screening and identification of α‐glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC/ MS and NMR. Biomedical Chromatography, 28(2), 148-155.
  • • Tosun, M., Ercisli, S., Ozer, H., Turan, M., Polat, T., Ozturk, E., Padem, H., & Kilicgun, H. (2012). Chemical composition and antioxidant activity of foxtail lily (Eremurus spectabilis). Acta Scientarum Polonorum Hortorum Cultus, 11(3), 145-153.
  • • Tramboo, A. M. (2013). In vivo study of anti-diabetic activity of Eremurus himalaicus. (Master Thesis, dissertation, University of Kashmir, India). Retrieved from http://ojs.uok.edu.in/jspui/bitstream/ 1/1320/1/Thesis%20Ahlam.pdf
  • • Ullah, S., Park, C., Ikram, M., Kang, D., Lee, S., Yang, J., Park, Y., Yoon, S., Chun, P., & Moon, H. R. (2019). Tyrosinase inhibition and antimelanin generation effect of cinnamamide analogues. Bioorganic Chemistry, 87, 43-55.
  • • Vala, M. H., Asgarpanah, J., Hedayati, M. H., Shirali, J., & Bejestani, F. B. (2011). Antibactrial and cytotoxic activity of Eremurus persicus (Jaub and Spach) Boiss. African Journal of Microbial Research, 16, 2349-2352.
  • • Vanni, A., Gastaldi, D., & Giunata, G. (1990). Kinetic investigations on the double enzymatic activity of the tyrosinase mushroom. Annals de Chimie et de Physique, 80, 35-60.
  • • Wittenauer, J., Mäckle, S., Sußmann, D, Schweiggert-Weisz, U., & Carle, R. (2015). Inhibitory effects of polyphenols from grape pomace extract on collagenase and elastase activity. Fitoterapia, 101, 179-187.
  • • Zafar, A., Alruwaili, N. K., Panda, D. S., Imam, S. S., Alharbi, K. S., Afzal, M., Shalaby, K., Kazmi, I., & Alshehri, S. (2021). Potential of natural bioactive compounds in management of diabetes: Review of preclinical and clinical evidence. Current Pharmacology Reports, http://dx.doi.org/10.1007/s40495-021-00255-8
  • • Zolghadri, S., Bahrami, A., Hassan Khan, M. T., Munoz-Munoz, J., Garcia-Molina, F., Garcia-Canovas, F., & Saboury, A. A. (2019). A comprehensive review on tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), 279-309.

Inhibitory effects of aqueous extract of Eremurus spectabilis M. Bieb. on diabetes mellitus and skin related enzymes

Year 2021, Volume: 51 Issue: 3, 357 - 364, 29.12.2021

Abstract

Background and Aims: Nutritional bioactive and natural ingredients isolated from wild edible plants, with promising effects against diabetes and/or diabetes-related diseases continue to be investigated. There is increasing interest in these substances due to their protective/therapeutic potential. The purpose of the present study is to investigate the inhibitory potential of aqueous extract of Eremurus spectabilis M. Bieb. on diabetes mellitus and skin-related enzymes. Methods: Fresh E. spectabilis leaves were obtained from a local market in Eyup/İstanbul, Turkey and their aqueous extract was prepared. Inhibitory activities of the aqueous extract of this plant on α-amylase, α-glucosidase, elastase, hyaluronidase, and tyrosinase were examined. Results: The aqueous extract of E. spectabilis showed effective inhibitor activity against both α-amylase and α-glucosidase as compared to acarbose. On the other hand, the aqueous extract exhibited a moderate inhibitory activity on elastase. Whereas, it exhibited a weak inhibitory effect on the activities of hyaluronidase and tyrosinase when compared to their respective standard inhibitors. Conclusion: The current findings suggest that the consumption of E. spectabilis leaves may be of benefit for regulation of postprandial blood glucose, as shown by the strongly inhibiting action of its extract on both α-amylase and α-glucosidase. In addition, it might be beneficial against skin-related disorders, because of its inhibitory action on elastase activity.

Supporting Institution

This study was supported by İstanbul University- Cerrahpaşa Scientific Research Projects Units

Project Number

52245

References

  • • Abubaker, S. R., & Hidayat, H. J. (2015). Anti-tumor potential of local aslerk (Eremurus spectabilis) leaf extracts by HPLC and applying on cancer cell lines in vitro. Iraqi Journal of Cancer and Medical Genetics, 8(2), 123-128.
  • • Acıkara, Ö. B., Ilhan, M., Kurtul, E., Šmejkal, K., & Küpeli Akkol, E. (2019). Inhibitory activity of Podospermum canum and its active components on collagenase, elastase and hyaluronidase enzymes. Bioorganic Chemistry, 93, 103330.
  • • Al-Dabbas M. M., Kitahara K., Suganuma T., Hasimato F., & Tadera K. (2006). Antioxidant and alpha-amylase inhibitory compounds from aerial parts of Varthemia iphionoides Boiss. Bioscience Biotechnology and Biochemistry, 70, 2178-2174.
  • • Apraj, V. D., & Pandita, N. S. (2016). Evaluation of skin anti‑aging potential of Citrus reticulata blanco peel. Pharmacognosy Research, 8(3), 160-168.
  • • Aysu, T., Demirbas, A., Bengü, A. Ş., & Küçük, M. M. (2015). Evaluation of Eremurus spectabilis for production of bio-oils with supercritical solvents. Process Safety and Environmental Protection, 94, 339-349.
  • • Behm, B., Schreml, S., Landthaler, M., & Babilas, P. (2012). Skin signs in diabetes mellitus. Journal of the European Academy of Dermatology and Venereology, 26(10), 1203-1211.
  • • Beiranvand, M., & Beiranvand, F. (2021). Iranian plant Eremurus persicus: an overview of botany, traditional uses, phytochemistry and pharmacology. Natural Product Research, http://dx.doi.org/10.108 0/14786419.2021.1916744
  • • Bircan, B., & Kırbağ, S. (2015). Determination of antioxidant and antimicrobial properties of Eremurus spectabilis Bieb. Artvin Coruh University Journal of Forestry Faculty, 16(2), 176-186. ISSN:2146- 1880, e-ISSN: 2146-698X
  • • Bonamonte, D., & Filoni, A. (2021). Impact of endocrine disorders on skin disorders. In Portincasa, P., Frühbeck, G., & Nathoe, H.M. (Eds.), Endocrinology and systemic diseases. Endocrinology. (pp. 399-435). Springer, Cham.
  • • Buhren, B. A., Schrumpf, H., Gorges, K., Reiners, O., Bölke, E., Fischer, J. W., Homey, B., & Gerber, P. A. (2020). Dose- and time-dependent effects of hyaluronidase on structural cells and the extracellular matrix of the skin. European Journal of Medicinal Research, 25, 60.
  • • Celik Onar, H., Yusufoglu, A., Turker, G., & Yanardag R. (2012). Elastase, tyrosinase and lipoxygenase inhibition and antioxidant activity of an aqueous extract from Epilobium angustifolium L. leaves. Journal of Medicinal Plants Research, 6(5), 716-726.
  • • Chiocchio, I., Mandrone, M., Sanna, C., Maxia, A., Tacchini, M., & Poli, F. (2018). Screening of a hundred plant extracts as tyrosinase and elastase inhibitors, two enzymatic targets of cosmetic interest. Industrial Crops and Products, 122, 498-505.
  • • Cinar, A., Tugrul Ay, S., Ayas, F., Karabak, S., Guzelsoy, N., & Ucurum, O. (2017). Foxtail lilly (Eremurus spectabilis M. Bieb.) as priority species biodiversity for food and nutrition project of Turkey. Anadolu Journal of Aegean Agricultural Research Institute, 27(2), 69-73.
  • • Dashti, M., Tavakoli, H., Zarif Ketabi, H., & Paryab, A. (2005). Study of ecological requirements of plant of Eremurus (Eremurus spectabilis M.B.) in Khorasan province. Iranian Journal of Range and Desert Research, 12(2),153-165.
  • • de Maceto, G. M., Nunes, S., & Barreto, T. (2016). Skin disorders in diabetes mellitus: An epidemiology and physiopathology review. Diabetology & Metabolic Syndrome, 8, 63.
  • • Demirkesen, C. (2015). Skin manifestations of endocrine diseases. Turkish Journal of Pathology, 31(Supp l), 145-154.
  • • Deniz, F. S. S., Salmas, R. E., Emerce, E., Cankaya, I. I. T., Yusufoglu, H. S., & Orhan, I. E. (2020). Evaluation of collagenase, elastase and tyrosinase inhibitory activities of Cotinus coggygria Scop. Through in vitro and in silico approach. South African Journal of Botany, 132, 277-288.
  • • Desmiaty, Y., Mulatsari, E., Saputri, F. C., Hanafi, M., Prastiwi, R., & Elya, B. (2020). Inhibition of pancreatic elastase in silico and in vitro by Rubus rosifolius leaves extract and its constituents. Journal of Pharmacy & Bioallied Science, 12(3), 317-323.
  • • Etsassala, N. G. E. R., Badmus, J. A., Waryo, T. T., Marnewick, J. L., Cupido, C. N., Hussein, A. A., & Iwuoha, E. I. (2019). Alpha-glucosidase and alpha-amylase inhibitory activities of novel abietane diterpenes from Salvia africana-lutea. Antioxidants (Basel), 8(10), 421.
  • • Gaggeri, R., Rossi, D., Azzolina, O., Ahmed, K. M., Avanzini, A., Mantelli, M., Gozzini, D., Paolillo, M. & Collina, S. (2013). Anti-inflammatory properties of ethanolic root extract of Eremurus persicus (Jaub and Spach) Boiss, a Kurdish herbal remedy. Journal of Medicinal Plant Research, 7, 1730-1735.
  • • Gaggeri, R., Rossi, D., Mahmood, K., Gozzini, D., Mannucci, B., Corana, F., Daglia, M., Avanzini, A., Mantelli, M., Martino, E., & Collina, S. (2015). Towards elucidating Eremurus root remedy: Chemical profiling and preliminary biological investigations of Eremurus persicus and Eremurus spectabilis root ethanolic extracts, Journal of Medicinal Plant Research, 8(41), 1038-1048.
  • • Gangadharan, A., Jacob, E., & Densely Jose, D. (2014). Phytochemical analysis, antibacterial and antihyaluronidase activity of three indigenous medicinal plants. World Journal of Pharmacy and Pharmaceutical Sciences, 3(6), 752-761.
  • • Genc, Y., Guragac Dereli, F. T., Saracoglu, I., & Kupeli Akkol, E. (2020). The inhibitory effects of isolated constituents from Plantago major subsp. major L. on collagenase, elastase and hyaluronidase enzymes: Potential wound healer. Saudi Pharmaceutical Journal, 28(1), 101-106.
  • • Gholamhoseinian, A., Hossein, F., Fariba, S., & Mirtaj Aldini, S. M. (2008). The inhibitory effect of some Iranian plants extracts on the alpha glucosidase. Iranian Journal of Basic Medical Science, 11(1), 1-9.
  • • Girish, K. S., & Kemparaju, K. (2007). The magic glue hyaluronan and its eraser hyaluronidase: A biological overview. Life Sciences, 80(21), 1921-1943.
  • • Gong, L., Feng, D., Wang, T., Ren, Y., Liu, Y., & Wang, J. (2020). Inhibitors of α-amylase and α-glucosidase: Potential linkage for whole cereal foods on prevention of hyperglycemia. Food Science & Nutrition, 8(12), 6320-6337.
  • • Karaoglan Esen, S., Gundogdu, G., Secme, M., Onur, S., Demirkaya Miloglu, F., Dodurga, Y., & Tufekci A. R. (2018). Eremurus spectabilis, rich source of isoorientin: isolation, quantification and anti-cancer activity on SH-SY5Y neuroblastoma cells. Current Pharmaceutical Analysis, 14(6), 578-585.
  • • Kumud, M., & Sanju, N. (2018). In-vitro evaluation of antioxidant, anti-elastase, anti-collagenase, anti-hyaluronidase activities of safranal and determination of its sun protection factor in skin photoaging. Bioorganic Chemistry, 77, 159-167.
  • • Lai, C. C. K., Nor, N. M., Kamaruddin, N. A., Jamil, A., & Safian, N. (2021). Comparison of transepidermal water loss and skin hydration in diabetics and nondiabetics. Clinical and Experimental Dermatology, 46(1), 58-64.
  • • Lankatillake, C., Luo, S., Flavel, M., Lenon, G. B., Gill, H., Huynh, T., & Dias, D. A. (2021). Screening natural product extracts for potential enzyme inhibitors: protocols, and the standardization of the usage of blanks in α-amylase, α-glucosidase, and lipase assays. Plant Methods 17, 3.
  • • Lee, K. K., Kim, J. H., Cho, J. J., & Choi, J. D. (1999). Inhibitory effects of 150 plant extracts on elastase activity, and their anti-inflammatory effects. International Journal of Cosmetic Science, 21, 71-82.
  • • Li, Z., & Ma, S. (2017). Recent advances in synthetic α-glucosidase inhibitors. ChemMedChem, 12(11), 819-829.
  • • Marrelli, M., Statti, G., & Conforti, F. (2020). A review of biologically active natural products from Mediterranean wild edible plants: Benefits in the treatment of obesity and its related disorders. Molecules, 25(3), 649.
  • • Mendes, A. L., Miot, H. A., & Haddad Junior, V. (2017). Diabetes mellitus and the skin. Anais Brasileiros De Dermatologia, 92(1), 8-20.
  • • Moon, J. Y., Yim, E. Y., Song, G., Lee, N. H., & Hyun, C. G. (2010). Screening of elastase and tyrosinase inhibitory activity from Jeju Island plants. Eurasian Journal of Biosciences, 4(1), 41-53.
  • • Mottaghipisheh, J., Kúsz, N., Hohmann, J., Tsai, Y. C., & Csupor, D. (2021). Isolation of secondary metabolites from the Iranian medicinal plant Eremurus persicus. Zeitschrift für Naturforschung, 76(1- 2), 43-47.
  • • Okyar, A., Can, A., Akev, N., Baktir, N., & Sutlupinar, N. (2001). Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models. Phytotheraphy Research, 15(2), 157-161.
  • • Pant, D. R., Aryal, B., Pun, D., Sharma, S. & Joshi, G. P. (2021). Inhibition of α-amylase and α -glucosidase activities in vitro by extracts of selected medicinal plants. Biodiversitas Journal of Biological Diversity, 22(3), 1187-1193.
  • • Papoutsis, K., Zhang, J., Bowyer, M. C., Brunton, N., Gibney, E. R., & Lyng, J. (2021). Fruit, vegetables, and mushrooms for the preparation of extracts with α-amylase and α-glucosidase inhibition properties: A review. Food Chemistry, 338, 128119.
  • • Pillaiyar, T., Manickam, M., & Namasivayam, V. (2017). Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 403-425.
  • • Sacan, O., Akev, N., & Yanardag, R. (2017). In vitro inhibitory effect of Aloe vera (L.) Burm. f. leaf extracts on the activity of some enzymes and antioxidant activity. Indian Journal of Biochemistry & Biophysics, 54, 82-89.
  • • Salehi, B., Ayatollahi, S. A., Segura-Carretero, A., Kobarfard, F., Contreras, M. D. M., Faizi, M., Sharifi-Rad, M., Tabatabai, S. A., & Sharifi- Rad, J. (2017). Bioactive chemical compounds in Eremurus persicus (Joub. & Spach) Boiss. essential oil and their health implications. Cellular and Molecular Biology, 63, 1-7.
  • • Svoboda, S. A., & Shields, B. E. (2021). Cutaneous manifestations of nutritional excess: Pathophysiologic effects of hyperglycemia and hyperinsulinemia on the skin. Cutis, 107, 74-78.
  • • Tao, Y., Zhang, Y., Cheng, Y., & Wang, Y. (2013). Rapid screening and identification of α‐glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC/ MS and NMR. Biomedical Chromatography, 28(2), 148-155.
  • • Tosun, M., Ercisli, S., Ozer, H., Turan, M., Polat, T., Ozturk, E., Padem, H., & Kilicgun, H. (2012). Chemical composition and antioxidant activity of foxtail lily (Eremurus spectabilis). Acta Scientarum Polonorum Hortorum Cultus, 11(3), 145-153.
  • • Tramboo, A. M. (2013). In vivo study of anti-diabetic activity of Eremurus himalaicus. (Master Thesis, dissertation, University of Kashmir, India). Retrieved from http://ojs.uok.edu.in/jspui/bitstream/ 1/1320/1/Thesis%20Ahlam.pdf
  • • Ullah, S., Park, C., Ikram, M., Kang, D., Lee, S., Yang, J., Park, Y., Yoon, S., Chun, P., & Moon, H. R. (2019). Tyrosinase inhibition and antimelanin generation effect of cinnamamide analogues. Bioorganic Chemistry, 87, 43-55.
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There are 52 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Article
Authors

Bertan Boran Bayrak 0000-0002-0700-5096

Refiye Yanardağ 0000-0003-4185-4363

Project Number 52245
Publication Date December 29, 2021
Submission Date May 7, 2021
Published in Issue Year 2021 Volume: 51 Issue: 3

Cite

APA Bayrak, B. B., & Yanardağ, R. (2021). Inhibitory effects of aqueous extract of Eremurus spectabilis M. Bieb. on diabetes mellitus and skin related enzymes. İstanbul Journal of Pharmacy, 51(3), 357-364.
AMA Bayrak BB, Yanardağ R. Inhibitory effects of aqueous extract of Eremurus spectabilis M. Bieb. on diabetes mellitus and skin related enzymes. iujp. December 2021;51(3):357-364.
Chicago Bayrak, Bertan Boran, and Refiye Yanardağ. “Inhibitory Effects of Aqueous Extract of Eremurus Spectabilis M. Bieb. On Diabetes Mellitus and Skin Related Enzymes”. İstanbul Journal of Pharmacy 51, no. 3 (December 2021): 357-64.
EndNote Bayrak BB, Yanardağ R (December 1, 2021) Inhibitory effects of aqueous extract of Eremurus spectabilis M. Bieb. on diabetes mellitus and skin related enzymes. İstanbul Journal of Pharmacy 51 3 357–364.
IEEE B. B. Bayrak and R. Yanardağ, “Inhibitory effects of aqueous extract of Eremurus spectabilis M. Bieb. on diabetes mellitus and skin related enzymes”, iujp, vol. 51, no. 3, pp. 357–364, 2021.
ISNAD Bayrak, Bertan Boran - Yanardağ, Refiye. “Inhibitory Effects of Aqueous Extract of Eremurus Spectabilis M. Bieb. On Diabetes Mellitus and Skin Related Enzymes”. İstanbul Journal of Pharmacy 51/3 (December 2021), 357-364.
JAMA Bayrak BB, Yanardağ R. Inhibitory effects of aqueous extract of Eremurus spectabilis M. Bieb. on diabetes mellitus and skin related enzymes. iujp. 2021;51:357–364.
MLA Bayrak, Bertan Boran and Refiye Yanardağ. “Inhibitory Effects of Aqueous Extract of Eremurus Spectabilis M. Bieb. On Diabetes Mellitus and Skin Related Enzymes”. İstanbul Journal of Pharmacy, vol. 51, no. 3, 2021, pp. 357-64.
Vancouver Bayrak BB, Yanardağ R. Inhibitory effects of aqueous extract of Eremurus spectabilis M. Bieb. on diabetes mellitus and skin related enzymes. iujp. 2021;51(3):357-64.