The Role of Neutrophile-Lymphocyte and Platelet- Lymphocyte Ratios in the Differential Diagnosis of Idiopathic Pulmonary Fibrosis and Chronic Hypersensitivity Pneumonia

Abstract

Abstract Aim Idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis (CHP) are interstitial lung diseases with overlapping clinical and radiological features, making differential diagnosis challenging. Inflammatory biomarkers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been investigated in various diseases. This study aims to evaluate the role of NLR and PLR in distinguishing IPF from CHP. Materials and Methods This retrospective study included patients diagnosed with IPF and CHP based on multidisciplinary discussion between January 2013 and December 2018 at a tertiary chest diseases hospital. The neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios were calculated from blood samples obtained at the time of diagnosis. Demographic characteristics, laboratory parameters, and comorbidities were extracted from hospital records. Statistical analyses were performed to compare NLR and PLR values between the study groups and a healthy control group. Conclusion Our results indicate that NLR values were significantly higher in both IPF and CHP groups compared to the healthy control group. However, there was no statistically significant difference between IPF and CHP groups, suggesting that NLR and PLR are not reliable markers for differentiating these diseases. Further studies are needed to explore alternative biomarkers for the differential diagnosis of IPF and CHP. Keywords Idiopathic pulmonary fibrosis, chronic hypersensitivity pneumonitis, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, inflammatory biomarkers

Keywords

• Idiopathic pulmonary fibrosis
• chronic hypersensitivity pneumonitis
• neutrophil-to-lymphocyte ratio
• platelet-to-lymphocyte ratio
• inflammatory biomarkers

Supporting Institution

None

Ethical Statement

The study was conducted in accordance with ethical principles and received ethical approval. Details are provided in the methodology section.

Thanks

None

İdiopatik Pulmoner Fibroz ve Kronik Hipersensitivite Ayırıcı Tanısında Nötrofil-Lenfosit ve Platelet-Lenfosit Oranının Rolü

Abstract

Amaç İdiyopatik pulmoner fibrozis (IPF) ve kronik hipersensitivite pnömonisi (CHP), klinik ve radyolojik olarak benzer özellikler gösteren interstisyel akciğer hastalıklarıdır ve ayırıcı tanıları zorludur. Nötrofil-lenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR) gibi inflamatuar biyobelirteçler, çeşitli hastalıklarda araştırılmıştır. Bu çalışmanın amacı, NLR ve PLR’nin IPF ile CHP'yi ayırt etmedeki rolünü değerlendirmektir. Gereç ve Yöntemler Bu retrospektif çalışma, Ocak 2013 ile Aralık 2018 tarihleri arasında üçüncü basamak bir göğüs hastalıkları hastanesinde multidisipliner tartışma ile IPF ve CHP tanısı alan hastaları içermektedir. Hastaların tanı anında alınan kan örneklerinden nötrofil-lenfosit ve trombosit-lenfosit oranları hesaplandı. Hastane kayıtlarından demografik özellikler, laboratuvar parametreleri ve ek hastalıklar analiz edildi. Çalışma grupları ile sağlıklı kontrol grubu arasındaki NLR ve PLR değerlerini karşılaştırmak için istatistiksel analizler yapıldı. Sonuç Çalışmamızda hem IPF hem de CHP gruplarında NLR değerlerinin sağlıklı kontrol grubuna kıyasla anlamlı derecede yüksek olduğu gözlemlendi. Ancak, IPF ve CHP grupları arasında istatistiksel olarak anlamlı bir fark bulunamadı. Bu durum, NLR ve PLR’nin bu iki hastalığın ayırıcı tanısında güvenilir biyobelirteçler olmayabileceğini göstermektedir. IPF ve CHP’nin ayırıcı tanısı için alternatif biyobelirteçleri araştıran ileri çalışmalara ihtiyaç duyulmaktadır. Anahtar Kelimeler İdiyopatik pulmoner fibrozis, kronik hipersensitivite pnömonisi, nötrofil-lenfosit oranı, trombosit-lenfosit oranı, inflamatuar biyobelirteçler

Keywords

• İdiyopatik pulmoner fibrozis
• kronik hipersensitivite pnömonisi
• nötrofil-lenfosit oranı
• trombosit-lenfosit oranı
• inflamatuar biyobelirteçler

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