BibTex RIS Cite
Year 2007, Volume: 1 Issue: 3, 97 - 106, 01.11.2007

Abstract

Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures

Year 2007, Volume: 1 Issue: 3, 97 - 106, 01.11.2007

Abstract

The aim of this work was to evaluate hippocampal neurons in the rat brain after single and repetetive seizures induced by pentyleneterazol (PTZ) administration at light- and electron-microscopically. Acute- and chronic-PTZ groups of male Wistar albino rats were given PTZ intraperitoneal injection (i.p.), and the age-matched rats in control group were injected with normal saline. We determined contributions of apoptosis and necrosis to neuronal damage in Nissl-stained- and ultrathin-sections. Necrotic neurons were observed in PTZ-treated groups, especially in the chronic-PTZ group. Histological changes were perikaryal swelling, chromatolysis and decreasing of Nissl in the necrotic neurons. Necrotic and apoptotic neurons of the hippocampus were observed ultrastructurally in the PTZ groups. These findings demonstrated a significant decrease in the number of hippocampal neurons in the chronic-PTZ group. It is clear that in the hippocampal regions repeated PTZ-induced seizures of the rats cause neuronal damage and neuronal loss

There are 0 citations in total.

Details

Other ID JA93UE84ST
Journal Section Research Article
Authors

Melda Yardımoglu This is me

Gul Ilbay This is me

Sibel Kokturk This is me

Funda Durmaz Onar This is me

Deniz Sahın This is me

Faruk Alkan This is me

Hakki Dalcık This is me

Publication Date November 1, 2007
Published in Issue Year 2007 Volume: 1 Issue: 3

Cite

APA Yardımoglu, M., Ilbay, G., Kokturk, S., Onar, F. D., et al. (2007). Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures. Journal of Applied Biological Sciences, 1(3), 97-106.
AMA Yardımoglu M, Ilbay G, Kokturk S, Onar FD, Sahın D, Alkan F, Dalcık H. Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures. J.appl.biol.sci. November 2007;1(3):97-106.
Chicago Yardımoglu, Melda, Gul Ilbay, Sibel Kokturk, Funda Durmaz Onar, Deniz Sahın, Faruk Alkan, and Hakki Dalcık. “Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures”. Journal of Applied Biological Sciences 1, no. 3 (November 2007): 97-106.
EndNote Yardımoglu M, Ilbay G, Kokturk S, Onar FD, Sahın D, Alkan F, Dalcık H (November 1, 2007) Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures. Journal of Applied Biological Sciences 1 3 97–106.
IEEE M. Yardımoglu, G. Ilbay, S. Kokturk, F. D. Onar, D. Sahın, F. Alkan, and H. Dalcık, “Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures”, J.appl.biol.sci., vol. 1, no. 3, pp. 97–106, 2007.
ISNAD Yardımoglu, Melda et al. “Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures”. Journal of Applied Biological Sciences 1/3 (November 2007), 97-106.
JAMA Yardımoglu M, Ilbay G, Kokturk S, Onar FD, Sahın D, Alkan F, Dalcık H. Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures. J.appl.biol.sci. 2007;1:97–106.
MLA Yardımoglu, Melda et al. “Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures”. Journal of Applied Biological Sciences, vol. 1, no. 3, 2007, pp. 97-106.
Vancouver Yardımoglu M, Ilbay G, Kokturk S, Onar FD, Sahın D, Alkan F, Dalcık H. Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures. J.appl.biol.sci. 2007;1(3):97-106.