Grape (Vitis vinifera L.) has been the subject of many research studies because of its phenolic compounds and antioxidant properties which are known to have positive effects on health. In this research study, some phytochemical contents of local and standard grape varieties widely grown in Diyarbakır province were determined. Amount of total phenolic, total anthocyanin and total flavonoid were examined in the berry seed, berry pulp and berry skin of each variety. The statistical differences among Boğazkere, Öküzgözü and Kızıl Banki were obtained and with the addition of Şire variety all varieties were compared in terms of statistical differences. Content of total phenolic was between 389.15 mg GAE / kg and 4050.17 mg GAE / kg, while content of total anthocyanin was recorded between 25.60 mg / kg and 634.00 mg / kg.Total flavonoid content was recorded from 2.34 mg CE /kg to 2402.00 mg CE/kg.With this study, it was determined that some phytochemical contents of different tissues of the grapes vary and this difference also occurs between the grape varieties.