jamer Journal of Anatolian Medical Research 2587-1153 Kayseri Şehir Eğitim ve Araştırma Hastanesi 10.55694/jamer.1410278 Dermatology Dermatoloji Atopik Dermatit Tedavisinde Biyolojik İlaçlar: Literatür Taraması Biological Drugs in the Treatment of Atopic Dermatitis: A Literature Review https://orcid.org/0009-0001-3757-277X Çalıcıoğlu Furkan SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, KAYSERİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0009-0004-8012-9986 Çalıcıoğlu Neşecan SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, KAYSERİ ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, DERMATOLOJİ ANABİLİM DALI https://orcid.org/0000-0001-5088-8923 Avcı Atıl SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, KAYSERİ ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, DERMATOLOJİ ANABİLİM DALI https://orcid.org/0000-0003-4290-2320 Ulaş Yılmaz SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, KAYSERİ ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, DERMATOLOJİ ANABİLİM DALI https://orcid.org/0000-0002-9269-2619 Ertaş Ragıp Medical Palace Hastanesi Dermatoloji 08 16 2024 9 2 36 51 12 27 2023 06 11 2024 Copyright © 2016, Journal of Anatolian Medical Research 2016 Journal of Anatolian Medical Research

Atopik dermatit; kronik, kaşıntılı, inflamatuar bir deri hastalığıdır. Pediatrik dönemde ve erişkinlik dönemindegörülebilen atopik dermatit; kaşıntı, kaşıntıya bağlı uyku bozuklukları, sosyal geri çekilme ve tedavi maliyetleriaçısından hastanın yaşam kalitesini doğrudan etkilemektedir. Topikal tedaviler, fototerapi yöntemleri, sistemikimmünsupresif ilaçlar ve biyolojik ajanlar atopik dermatit tedavisinde kullanılmaktadır. Biyolojik ajanlar; hızlıetki başlangıçları ve kaşıntının sürdürülebilir kontrolünde oldukça önemli bir rol üstlenmektedir. Semptomlarınkontrolünde etkili ilaçlar olmaları ve konvansiyonel immünsupresif ilaçlara göre daha az yan etkiye sahip olmalarısebebiyle biyolojik ajanlar atopik dermatit tedavisinde gelecekte daha sık kullanılabilir. Atopik dermatit tedavisiile ilgili araştırmalar sürdükçe yeni biyolojik ilaçlar üretilmeye ve kullanılmaya devam edecektir. Atopik dermatittedavisinde kullanılan biyolojik ajanların faz çalışmalarının sonuçlarını ve gerçek yaşam verilerini sentezleyerekpaylaşmak istiyoruz. Farklı mekanizmalar üzerinden ilaçların etkilerini, vaka sonuçlarını, karşılaşılan yan etkileri,tedavi sürdürülebilirliğini ve uzun dönem risklerini bir bütün olarak ortaya koymayı ve tartışmayı amaçlıyoruz.

Atopic dermatitis is a chronic, pruritic, inflammatory skin condition that affects both children and adults, significantlyimpacting patients’ quality of life due to itching, sleep disturbances caused by itching, social withdrawal, andtreatment expenses. The treatment of atopic dermatitis involves various approaches, including topical therapies,phototherapy, systemic immunosuppressants, and biological agents. Biologics are particularly noteworthy for theirrapid onset of action and sustained ability to manage pruritus. Given their effectiveness in symptom control andlower incidence of adverse effects compared to traditional immunosuppressive medications, biological drugs arelikely to see increased utilization in the future for treating atopic dermatitis. Ongoing research in this field isexpected to lead to the development and utilization of novel biologics. This study aims to provide a comprehensiveoverview of phase studies and real-world data on the use of biological agents in atopic dermatitis treatment. Theobjective is to analyze and discuss the drugs’ effects based on their mechanisms of action, clinical outcomes, sideeffect profiles, treatment durability, and long-term safety considerations.

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