Blood Vessel Segmentation and Classification of Diabetic Retinopathy with Machine Learning-Based Ensemble Model
Year 2024,
Volume: 10 Issue: 3, 560 - 570, 30.09.2024
Cihan Akyel
,
Bünyamin Ciylan
Abstract
The incidence of diabetes has increased in recent times due to factors such as obesity and genetic predisposition. Diabetes wears out the eye vessels over time. Diabetic retinopathy (DR) is a serious disease that leads to vision problems. DR can be diagnosed by specialists who examine the fundus images of the eye at regular intervals. With 537 million diabetics in 2021, this method can be time-consuming, costly and inadequate. Artificial intelligence algorithms can provide fast and cost-effective solutions for DR diagnosis. In this study, the noise of blood vessels in fundus images was eliminated using the LinkNet-RCB7 model, and diabetic retinopathy was categorized into five classes using a machine learning-based ensemble model. Artificial intelligence-based classification training using images as input takes a long time and requires high resource requirements such as Random Access Memory (RAM) and Graphics Processing Unit (GPU). By using Gray Level Cooccurrence Matrix (GLCM) attributes in the classification phase, a lower resource requirement was aimed for. A Dice coefficient of 85.95% was achieved for the segmentation of blood vessels in the Stare dataset, in addition to 97.46% accuracy for binary classification and 96.10% accuracy for classifying DR into five classes in the dataset APTOS 2019.
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Year 2024,
Volume: 10 Issue: 3, 560 - 570, 30.09.2024
Cihan Akyel
,
Bünyamin Ciylan
References
- M. J. Hossain, M. Al-Mamun, M. R. Islam, Diabetes mellitus, the fastest growing global public health concern: Early detection should be focused, Health Science Reports 7 (3) (2024) 1–5.
- S. İnan, Diabetic retinopathy and etiopathogenesis, Kocatepe Medical Journal 15 (2) (2014) 207–217.
- L. Dai, L. Wu, H. Li, C. Cai, Q. Wu, H. Kong, R. Liu, X. Wang, X. Hou, Y. Liu, X. Long, Y. Wen, L. Lu, Y. Shen, Y. Chen, D. Shen, X. Yang, H. Zou, B. Sheng, W. Jia, A deep learning system for detecting diabetic retinopathy across the disease spectrum, Nature Communications 12 (2021) 3242 11 pages.
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- N. Sikder, M. Masud, A. Bairagi, A. Arif, A. Nahid, H. A. Alhumyani, Severity classification of diabetic retinopathy using an ensemble learning algorithm through analyzing retinal images, Symmetry 13 (4) (2021) 670–696.
- U. Ishtiaq, E. Abdullah, Z. Ishtiaque, A hybrid technique for diabetic retinopathy detection based on ensemble-optimized CNN and texture features, Diagnostics 13 (10) (2023) 1–21.
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- A. Hoover, V. Kouznetsova, M. Goldbaum, Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response, IEEE Transactions on Medical Imaging 19 (3) (2000) 203–210.
- S. Kılıçarslan, A novel nonlinear hybrid HardSReLUE activation function in transfer learning architectures for hemorrhage classification, Multimedia Tools Applications 82 (2023) 6345–6365.
- C. Közkurt, A. Diker, A. Elen, S. Kılıçarslan, E. Dönmez, F. B. Demir, Trish: An efficient activation function for CNN models and analysis of its effectiveness with optimizers in diagnosing glaucoma, The Journal of Supercomputing 2024 (2024) 1–32.
- J. Staal, M. D. Abràmoff, M. Niemeijer, M. A. Viergever, B. Van Ginneken, Ridge-based vessel segmentation in color images of the retina, IEEE Transactions on Medical Imaging 23 (4) (2004) 501–509.
- K. Dane, M. Dane, S. Dane, APTOS 2019 Blindness Detection (2019), https://kaggle.com/competitions/aptos2019-blindness-detection, Accessed 1 May 2024.
- C. Akyel, N. Arıcı, Decision support system for blood vessel and optic disc segmentation, Gazi Journal of Engineering Sciences, 9 (1) (2023) 12–26.
- C. Akyel, N. Arıcı, LinkNet-B7: Noise removal and lesion segmentation in images of skin cancer, Mathematics 10 (5) (2022) 736–751.
- C. Akyel, N. Arıcı, Hair removal and lesion segmentation with FCN8-ResNetC and Image processing in images of skin cancer, Journal of Information Technologies 15 (2) (2022) 231–238.