The purpose of present research was to investigate effects of a probiotic, a prebiotic and two synbiotics consumption on total antioxidant (TAO) capacity, malondialdehyde (MDA) level, percentages of heterophils, lymphocytes, heterophils /lymphocytes (H/L) ratio as a stress indicator, and albumin, globulin and albumin/globulin (A/G) ratio as a oncotic pressure indicator of blood in Japanese quails. The experimental diets consisted of a basal diet without additive (control), protexin® as a probiotic, fermacto® as a prebiotic, mixed of protexin® and fermacto® as a synbiotic, and Biomin-IMBO® as a other synbiotic, were added to the basal diet and with water were available ad libitum from 1 to 42 days of age of quails. The consumption of these additives had not significant effect on TAO capacity in females and on MDA in both genders, but consumption of prebiotic caused enhancement of TAO capacity of males (P<0.05). The H/L ratio of females fed by additives especially Biomin-IMBO® were lower comparison to control group (P<0.05). The blood albumin was enhanced in males fed by additives especially mixed of protexin® and fermacto® as synbiotic (P<0.05). The A/G ratio was increased by consumption of additives especially with each two synbiotics (P<0.05). The results show that the combination of probiotic and prebiotic as synbiotic is benefit additive for quails feeding. The synergetic effects of synbiotics in improving of live benefit microbial, absorption of necessary nutrients and providing of suitable environment in the gastrointestinal tract are important for health of blood indicators in Japanese quails.