Changing of Uric Acid Levels by Age and Sex in Patients with Diabetes Mellitus

Year 2016, Volume: 7 Issue: 1, 1 - 6, 01.03.2016

Nilgün Basaran Osman Evliyaoglu Veysel Sucu Okan Dikker Leyla Bulut Fatma Tezcan Vesile Kalaslıoğlu Rıza Sandıkçı Müberra Vardar

https://doi.org/10.5799/jcei.328707

Abstract

Objective: We examined the association between uric acid and glycemic status by the aspects of age and sex.
Methods: The retrospective was performed study at Okmeydanı Educate and Research Hospital. All data were obtained
from the patient records. Only one sample of HbA1c or glucose measurement within a year was included. To evaluate
the pattern of glucose control, we categorized the patients according to HbA1c levels and grouped them according to
a range of values. HbA1c was measured by high performance liquid chromatography, routine biochemistry parameters
were determined by photometric method.
Results: Serum uric acid levels showed an increasing trend with the age in female group and this trend became significant
after 30 years old (p<0.001). The significant effect of HbA1c and gender on uric acid levels were determined in the
subjects having no renal failure. There was a significant increase of uric acid levels in prediabetics than normal group
and decrease in unregulated diabetics. But in both sex groups the pattern of changing was different.
Conclusion: In conclusion, we found that age is an important factor examining the serum uric acid levels of female
subjects. The peak values of serum uric acid were detected in prediabetic group in males but in females this peak point
was diabetic group. J Clin Exp Invest 2016; 7 (1): 1-6

Keywords

Diabetes mellitus, uric acid, age, gender

References

• 1. Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol 2007;293:584-596.
• 2. Souza-Junior T, Lorenço-Lima L, Ganini D, et al. Delayed uric Acid accumulation in plasma provides additional antioxidant protection against iron-triggered oxidative stress after a Wingate test. Biol Sport 2014;31:271-276.
• 3. Corry DB, Eslami P, Yamamoto K, et al. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. J Hypertens 2008;26:269-275.
• 4. Oberbach A, Neuhaus J, Jehmlich N, et al. A global proteome approach in uric acid stimulated human aortic endothelial cells revealed regulation of multiple major cellular pathways. Int J Cardiol 2014;176:746-752.
• 5. Verdoia M, Barbieri L, Schaffer A, et al. Novara Atherosclerosis Study Group (NAS). Impact of diabetes on uric acid and its relationship with the extent of coronary artery disease and platelet aggregation: a single-centre cohort study. Metabolism 2014;63:640-646.
• 6. Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 2005;16:3553-3562.
• 7. Yamamoto T. Definition and classification of hyperuricemia. Nihon Rinsho 2008;66:636-640.
• 8. Wang SF, Shu L, Wang S, et al. Gender difference in the association of hyperuricemia with hypertension in a middleaged Chinese population. Blood Press 2014;23:339-344.
• 9. Bian S, Guo H, Ye P, et al. Serum uric Acid level and diverse impacts on regional arterial stiffness and wave reflection. Iran J Public Health 2012;41:33-41.
• 10. Lee YJ, Cho S, Kim SR. A possible role of serum uric acid as a marker of metabolic syndrome. Intern Med J 2014;44:1210-1216.
• 11. Liu WC, Hung CC, Chen SC, et al. The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese. Exp Diabetes Res 2011;527520:1-6.
• 12. Sun X, Zhang R, Jiang F, et al. Common variants related to serum uric Acid concentrations are associated with glucose metabolism and insulin secretion in a chinese population. PLoS One 2015;10:116714.
• 13. DeBosch BJ, Kluth O, Fujiwara H, et al. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun 2014 ;5:4642.
• 14. Xu Y, Zhu J, Gao L, et al. Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysis. PLoS One. 2013;8:78206.
• 15. Krishnan E, Pandya BJ, Chung L, et al. Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes: a 15-year follow-up study. Am J Epidemiol 2012;176:108-116.
• 16.Bhole V, Choi JW, Kim SW, et al., Serum uric acid levels and the risk of type 2 diabetes: a prospective study. Am J Med 2010;123:957–961.
• 17. Kodama S, Saito K, Yachi Y, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care 2009;32:1737-1742.
• 18. Jia Z, Zhang X, Kang S, Wu Y. Serum uric acid levels and incidence of impaired fasting glucose and type 2 diabetes mellitus: a meta-analysis of cohort studies. Diabetes Res Clin Pract 2013;101:88-96.
• 19. Fan HQ, Tang W, Wang ZX, et al. Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c. PLoS One 2013;8:67759.
• 20. Lippi G, Montagnana M, Franchini M, et al. The paradoxical relationship between serum uric acid and cardiovascular disease. Clin Chim Acta 2008;392:1-7.
• 21. Sumino H, Ichikawa S, Kanda T, et al. Reduction of serum uric acid by hormone replacement therapy in postmenopausal women with hyperuricaemia. Lancet 1999;354:650.
• 22. Lebovitz HE, Austin MM, Blonde L, et al. ACE/AACE Diabetes Road Map Task Force. Road maps to achieve glycemic control in type 2 diabetes mellitus: ACE/AACE Diabetes Road Map Task Force. Endocr Pract 2007;13:260–268.
• 23. American Diabetes Association. Standards of Medical Care in Diabetes. Diabetes Care 2010; 33(Suppl 1):S11–S61.
• 24. Ishizaka N, Ishizaka Y, Toda E, et al. Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals. Arterioscler Thromb Vasc Biol 2005;25:1038-1044.
• 25. Nakamura K, Sakurai M, Miura K, et al. HOMA-IR and the risk of hyperuricemia: a prospective study in non-diabetic Japanese men. Diabetes Res Clin Pract 2014;106:154-160.
• 26. Andrade JA, Kang HC, Greffin S, et al. Serum uric acid and disorders of glucose metabolism: the role of glycosuria. Braz J Med Biol Res 2014;47:917-923.