A Single Nucleotide Polymorphism of Follicle-Stimulating Hormone Receptor Gene in Turkish Women With Polycystic Ovary Syndrome: A Cross-Sectional Study

Year 2017, Volume: 8 Issue: 2, 39 - 44, 30.06.2017

Ümit Naykı

https://doi.org/10.5799/jcei.333378

Abstract

Objective: The aim of this study was to evaluate both the frequency of Asn680Ser polymorphism
of follicle stimulating hormone receptor (FSHR) and whether this polymorphism is associated
with polycystic ovary syndrome (PCOS) in a Turkish population.
Patients and Methods: 100 patients with PCOS and 100 controls were recruited from Eastern
Turkey. Venous blood samples were obtained for genetic study, hormone profile, glucose and
insulin assays. Asn680Ser polymorphism of FSHR was analyzed by polymerase chain reaction
(PCR) amplification and direct DNA sequencing. Two groups were compared for body mass
index (BMI), modified Ferriman-Gallwey (mFG) score, fasting glucose, fasting insulin, insulin
resistance, hormone and lipid status. Then, all patients were divided into subgroups for
genotypes of FSHR polymorphism. These subgroups were also compared for these mentioned
parameters.
Results: The difference between women with PCOS and controls in allelic frequencies for
Asn680Ser polymorphism of FSHR were not significant. When this single nucleotide
polymorphism (SNP) at codon 680 was separately analyzed, no significant difference was found
in the genotype frequency among the Asn680Asn, Asn680Ser, andSer680Ser subgroups. There
were no significant differences in BMI, mFG score, levels of fasting glucose and fasting insulin,
HOMA-IR, and also levels of FSH, luteinizing hormone, estradiol, prolactin, thyroid stimulating
hormone, total testosterone among the PCOS patients carrying different genotypes of
Asn680Ser polymorphism
Conclusion: there is no association between Asn680Ser polymorphism of FSHR and PCOS in
Turkish women from eastern provinces of Turkey. In addition, this SNP seems not to be
associated with BMI, IR and PCOS-associated endocrine hormones.

Keywords

Polycystic ovary syndrome, follicle stimulating hormone receptor, single nucleotide polymorhism

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